Results 111 to 120 of about 82,032 (316)

Prospects for the use of prolonged concentrates of blood clotting factor IX in the treatment of hemophilia B

, 2021
V. N. Konstantinova, T. A. Andreeva, A. V. Kim   +2 more
openalex   +1 more source

Thrombin Generation in Pediatric Haemophilia A Patients on Extended Half‐Life FVIII versus Non‐FVIII Therapies

Haemophilia, EarlyView.
ABSTRACT Introduction The therapeutic landscape for patients with haemophilia A (PwHA) is rapidly evolving with the introduction of extended half‐life FVIII (EHL‐FVIII) and non‐FVIII therapies that mimic FVIII, such as emicizumab (EMI). Monitoring non‐factor therapies in the laboratory poses challenges; however, the thrombin generation assay (TGA) can ...
Jessica Garcia, Sean G. Yates, Ravi Sarode, Guy Young, Ayesha Zia   +4 more
wiley   +1 more source

Emicizumab in the treatment of acquired hemophilia A: A Two-Center experience

Annals of Hematology
Emicizumab is a FVIII mimetic antibody used in the treatment of inherited hemophilia A that could potentially be used in acquired hemophilia A (AHA) to achieve hemostasis and shorten hospital stay while reducing bypass therapies. We report on 12 cases of
Malcolm Su, Sean Yates, Melissa Sanchez, Yu-Min Shen   +3 more
doaj   +1 more source

More on: intensive factor VIII exposure and inhibitor development in mild hemophilia A [PDF]

, 2004
Manuel Carção
openalex   +1 more source

Delphi Consensus Recommendations for the Definition of a Severe Bleeding Phenotype and Initiation of Prophylaxis in Patients With Non‐Severe Haemophilia

Haemophilia, EarlyView.
ABSTRACT Introduction Current guidelines recommend prophylaxis for patients with non‐severe haemophilia with severe bleeding phenotype (SBPT) but there is no consensus how to define a SBPT and when to recommend prophylaxis in patients with non‐severe haemophilia. Method A Delphi consensus procedure among the members of the Standing Committee Hemophilia
Christian Pfrepper, Cihan Ay, Ralf Knöfler, Christoph Königs, Manuela Krause, Wolfgang Miesbach, Johannes Oldenburg, Michael Sigl‐Kraetzig, Rosa Sonja Alesci, Martin Olivieri, for the Standing Committee Hemophilia of the GTH   +10 more
wiley   +1 more source

Successful management of concurrent acquired hemophilia A and a lupus anticoagulant in a pediatric hematopoietic stem cell transplant patient [PDF]

, 2018
LaQuita M. Jones, Christopher E. Dandoy, Sonata Jodele, Kasiani C. Myers, Lori Luchtman‐Jones, Charles T. Quinn, Eric S. Mullins, Javier El‐Bietar   +7 more
openalex   +1 more source

Cyclosporine treatment of acquired hemophilia due to factor VIII antibodies [PDF]

, 2000
Acquired hemophilia, caused by autoantibodies against coagulation factor VIII, is usually treated with steroids, cyclophosphamide, intravenous gammaglobulins and sporadically other drugs.
Baele, Gaston, Derom, Eric, Petrovic, Mirko   +2 more
core  

Treatment With Valoctocogene Roxaparvovec in a Patient With Severe Hemophilia A Led to Sustained Normal FVIII Levels

Haemophilia, EarlyView.
ABSTRACT Introduction Valoctocogene roxaparvovec, an adeno‐associated virus (AAV)‐based gene therapy, enables endogenous factor VIII (FVIII) expression in patients with severe hemophilia A without the need for regular FVIII infusions. Long‐term follow‐up assesses durability, safety, and immune‐related challenges following gene therapy.
Kerstin Herbst, Behnaz Pezeshkpoor, Claudia Klein, Thilo Albert, Philipp Lutz, Christian Strassburg, Ulrich Spengler, Georg Goldmann, Johannes Oldenburg   +8 more
wiley   +1 more source

Hemophilia gene therapy is effective and safe [PDF]

, 2018
Michael Makris
openalex   +1 more source

Postpartum Acquired Hemophilia A

Journal of Community Hospital Internal Medicine Perspectives
Acquired hemophilia A (AHA) is a bleeding disorder that occurs from aberrant production of autoantibodies that target factor VIII. The underlying cause of AHA is unclear but can present postpartum. Very few cases have reported instances of AHA coexisting with other hematological disorders, such as sickle cell trait (SCT).
Omar, Khawaja O., Sebastian, William, Kemper, Suzanne   +2 more
openaire   +2 more sources