Results 121 to 130 of about 82,032 (316)
ABSTRACT Introduction Despite available prophylactic therapies for haemophilia A, breakthrough bleeding and consequent pain and joint damage still occur. Aim To provide insights into the unmet treatment needs of people with moderate‐to‐severe haemophilia A in the US.
Allison P. Wheeler +14 more
wiley +1 more source
Hemophilia treatment and transfusion medicine
The improvement of hemophilia treatment is attributed to the development of transfusion medicine, and the discovery of cryoprecipitate has opened up a new era of hemophilia treatment, laying the foundation for the development of modern hemophilia ...
FANG Yunhai, CHENG Yan, ZHANG Xinsheng
doaj +1 more source
Budget impact analysis of use of BPA anti-inhibitor coagulant complex (aicc) and eptacog alfa [activated] in the prophylaxis of bleedings in inhibitor hemophilia patients [PDF]
V.G. Serpik, R.I. Yagudinа
openalex +1 more source
Sociodemographic and clinical characteristics of persons who experienced spontaneous hepatitis C viral clearance. [PDF]
BackgroundIn the United States Hepatitis C virus (HCV) viral clearance is estimated to range between 20 and 30%. The objective of this study was to estimate the frequency of HCV clearance and identify correlates of viral clearance among patients newly ...
Baik, Yeonsoo +8 more
core
Performing Large‐Scale Genetic Analysis in the Bleeding Disorders Community
ABSTRACT Inherited bleeding disorders encompass a diverse group of conditions caused by genetic defects affecting coagulation factors, fibrinogen, von Willebrand factor, or platelet function. Despite major advances in quantitative and functional laboratory assays, a substantial diagnostic gap remains, particularly in patients with mild or atypical ...
Anna R. Blankstein +6 more
wiley +1 more source
Maximum Likelihood Estimation of the Multivariate Normal Mixture Model [PDF]
The Hessian of the multivariate normal mixture model is derived, and estimators of the information matrix are obtained, thus enabling consistent estimation of all parameters and their precisions.
Boldea, Otilia, Magnus, Jan R.
core +1 more source
Assessing the Impact of the 2021 VWD Guidelines on the Diagnosis/Management of Low VWF Patients
ABSTRACT Introduction The 2021 ASH/ISTH/NHF/WFH VWD diagnosis guidelines recommend Type 1 VWD diagnoses for patients with (a) VWF <0.30 IU/mL or (b) ‘Low VWF’ 0.30–0.50 IU/mL with the presence of abnormal bleeding. This recommendation recategorizes ‘Low VWF’ patients with abnormal bleeding into Type 1 VWD.
Michael Dong +4 more
wiley +1 more source
66. Effective Treatment of Hemophilia A Using Hematopoietic Stem Cell Transplantation and a Bioengineered Factor VIII Transgene [PDF]
openalex +1 more source

