Results 191 to 200 of about 22,643,381 (355)

Maximum Likelihood Estimation of the Multivariate Normal Mixture Model [PDF]

The Hessian of the multivariate normal mixture model is derived, and estimators of the information matrix are obtained, thus enabling consistent estimation of all parameters and their precisions.
Boldea, Otilia, Magnus, Jan R.
core   +1 more source

Isolation and Properties of the Abnormal Factor IX Molecule of Hemophilia BM [PDF]

, 1977
Bjarne Østerud, K K Lavine, Carol K. Kasper, Samuel I. Rapaport   +3 more
openalex   +1 more source

Outcomes of Dental Treatment Procedures in People With Haemophilia Treated Under a Comprehensive Care Model: An Analysis of Cases From a Tertiary Care Centre

Haemophilia, EarlyView.
ABSTRACT Background Haemophilia is a chronic, lifelong bleeding disorder that requires interdisciplinary care to manage and mitigate the disease burden throughout a patient's life. There is no universally accepted protocol for managing haemophilia patients during dental care.
Mathangi Kumar, Sulochana Badagabettu, Keerthilatha M. Pai, Annamma Kurien, Archana MV, Shreemathi S. Mayya, Sreejith Govindan   +6 more
wiley   +1 more source

Profiling of Anti‐FVIII Antibodies in Acquired Haemophilia A: ‘Insights into Domain Specificity, Isotype Variability, and Clinical Correlations’

Haemophilia, EarlyView.
ABSTRACT Introduction Acquired haemophilia A (AHA) is a rare autoimmune disorder caused by autoantibodies against coagulation factor VIII (FVIII), resulting in significant bleeding risks. Aim To characterize the anti‐FVIII antibody profile in AHA patients by assessing isotypes, subclasses, and correlations with key clinical parameters.
Ann‐Cristin Berkemeier, Isabell Matuschek, Katrin Hartlieb, Thilo Albert, Natascha Marquardt, Johannes Oldenburg, Behnaz Pezeshkpoor   +6 more
wiley   +1 more source

Collected Experience of the Pennsylvania Hemophilia Program [PDF]

, 1977
S.S. Shapiro, M.E. Eyster, J. Lewis
openalex   +1 more source

A Global Cross‐Sectional Database Study of Low Dose FVIII SHL Prophylaxis in Haemophilia A

Haemophilia, EarlyView.
ABSTRACT Introduction Haemophilia treatment is costly and only 25% of patients receive adequate care. Although not optimal, Factor VIII (FVIII) low‐dose prophylaxis (LDP) may reduce annual joint bleeding rates. Understanding FVIII usage, collected through the Web‐Accessible Population Pharmacokinetic Service–Hemophilia (WAPPS‐Hemo) platform, and its ...
Dagmar M. Hajducek, Oceana Sinkovic, Pierre Chelle, Alfonso Iorio, Andrea Edginton   +4 more
wiley   +1 more source

Defibrination Syndrome Developed after Replacement Therapy with PPSB in a Case of Hemophilia B. [PDF]

, 1977
Mutsuyoshi Kazama, H Iwakura, Masaru Nakajima, M. Abe, Tetsuya Abe   +4 more
openalex   +1 more source

Experiences and Needs Regarding Information Provision in Children With Haemophilia: A Qualitative Study on Caregivers’ and Healthcare Providers’ Perspectives

Haemophilia, EarlyView.
ABSTRACT Introduction In haemophilia, ever more effective treatment options leading to minimal bleeding make information provision about the disease and its symptoms and when to alert the treatment team increasingly important. However, little is known about how current information provision is perceived and what the needs are.
Caroline M. A. Mussert, Nadia C. W. Kamminga, Evelien S. van Hoorn, Tjaisha M. Eekelaar, Silje R. Dehli, Carolien van der Velden‐van ‘t Hoff, Sasja Andeweg, Simone H. Reitsma, Annebelle C. M. Nooteboom, Adinda Diekstra, Armaĝan Albayrak, Marjon H. Cnossen, the SYMPHONY consortium   +12 more
wiley   +1 more source

AAV5–Factor VIII Gene Transfer in Severe Hemophilia A

New England Journal of Medicine, 2017
S. Rangarajan, L. Walsh, W. Lester, D. Perry, B. Madan, M. Laffan, Hua Yu, Christian Vettermann, G. Pierce, W. Wong, J. Pasi   +10 more
semanticscholar   +1 more source

Burden of Haemophilia A in South Korea: A Serial Cross‐Sectional Study From 2008 to 2021

Haemophilia, EarlyView.
Abstract Background Overall use of factor VIII (FVIII) and prophylactic use have increased in South Korea over the past decade. However, there are no nationwide outcome data demonstrating its impact. This study aimed to identify patients with haemophilia A (PwHA) and observe trends in joint‐related outcomes and life‐threatening haemorrhages using ...
Sun‐Hong Kwon, Ji Kyoung Park, Hee Jo Baek, Jin Hyun Nam, Serim Min, Ae‐Ryeo Cho, Aeran Jung, Young‐Shil Park   +7 more
wiley   +1 more source