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Hemophilia A and Hemophilia B: Different Types of Diseases?
Seminars in Thrombosis and Hemostasis, 2013Hemophilia A and B are traditionally considered clinically indistinguishable; however, differences in bleeding frequency, clinical scores, use of prophylaxis, and need for orthopedic surgery have been reported, suggesting that the bleeding tendency associated with factor IX deficiency may be less severe with consequent better outcomes in the long term ...
Elena, Santagostino +1 more
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Group B Streptococcal Polyarthritis Complicating Hemophilia B
Acta Haematologica, 1990We report a case of polyarticular group B streptococcal infection in an HIV-negative 46-year-old alcoholic with factor IX deficiency. Septic arthritis occurs infrequently in the hemophilic population despite their chronic joint disease; indications for diagnostic arthrocentesis in these individuals are discussed. The group B streptococcus often behaves
L C, Hartmann, W M, Nauseef
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Hemophilia B Mutational Analysis
2003Since the cloning of the factor IX gene in 1982 (1), there have been several strategies employed for the identification of mutations in the mutationally heterogeneous hemophilia B population. Initially, such strategies inevitably employed Southern blotting to screen for gross deletions (2) or restriction site alterations (3), and cloning of the ...
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Journal of the American Medical Association, 1959
A 22-year-old man was hospitalized with complaints of dyspnea and hemoptysis and a history of heart disease and coagulation defects. Repeated study of the clotting mechanism showed the outstanding deficits to be those of thromboplastin generation characteristic of hemophilia B.
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A 22-year-old man was hospitalized with complaints of dyspnea and hemoptysis and a history of heart disease and coagulation defects. Repeated study of the clotting mechanism showed the outstanding deficits to be those of thromboplastin generation characteristic of hemophilia B.
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Molecular Analysis of Hemophilia B: »Greifswald Registry FIX Deficiency (Hemophilia B)«
2003Hemophilia B (HB) is due to multiple defects in the factor IX gene. More than 90% of mutants are single substitutions, small additions (
K. Wulff, W. Schröder, Rh. Herrmann
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2001
Hemophilia B is a recessive X-linked bleeding disorder caused by a deficiency of the clotting factor IX (FIX). The FIX gene is located on the long arm of X chromosome at Xq 27 and the genomic sequence was analyzed by Yoshitake et al. (1985).
K. Wulff, W. Schröder, F. H. Herrmann
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Hemophilia B is a recessive X-linked bleeding disorder caused by a deficiency of the clotting factor IX (FIX). The FIX gene is located on the long arm of X chromosome at Xq 27 and the genomic sequence was analyzed by Yoshitake et al. (1985).
K. Wulff, W. Schröder, F. H. Herrmann
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2018
This chapter outlines the pathophysiology, clinical presentation, inheritance, and incidence of hemophilia A and B. The chapter describes the interaction with pregnancy and discusses the medical and anesthetic management of pregnant women with hemophilia A and B, including treatment of acute hemorrhage.
James P. R. Brown, Joanne Douglas
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This chapter outlines the pathophysiology, clinical presentation, inheritance, and incidence of hemophilia A and B. The chapter describes the interaction with pregnancy and discusses the medical and anesthetic management of pregnant women with hemophilia A and B, including treatment of acute hemorrhage.
James P. R. Brown, Joanne Douglas
openaire +1 more source