Results 41 to 50 of about 12,392,515 (266)

Hemophilia B

, 2021
Hemophilia B, also known as Christmas disease, is the second most common type of hemophilia. The disease was named after Stephen Christmas, who was the first person diagnosed with the condition in 1952.
Alshaikhi, Alfarooq, Rokkam, Venkata R
core   +1 more source

Precision medicine in paediatrics: Progress and priorities

British Journal of Clinical Pharmacology, EarlyView.
Precision medicine is revolutionizing personalized healthcare, advancing both diagnostics and therapeutics at an unprecedented pace. Reviewing the paediatric applications of pharmacometrics, pharmacogenomics and advanced therapy medicinal products highlights not only the relevance of these exciting innovations to frontline care but also the significant
Nicola Husain, Claire Booth, Joseph F. Standing, Charlotte I. S. Barker   +3 more
wiley   +1 more source

Serum Vitamin D in Children with Hemophilia A and Its Association with Joint Health and Quality of Life

Hematology Reports
Background/Objectives: Hemophilia A is an X-linked recessive illness produced by a deficiency of coagulation factor VIII. This study aimed to evaluate serum vitamin D in hemophilic pediatric patients and its correlation with joint health and quality of ...
Aida M. S. Salem, Takwa Mohamed AbdEltwwab, Hanan Hosni Moawad, Marwa O. Elgendy, Reham S. Al-Fakharany, Ahmed Khames, Mohamed Hussein Meabed   +6 more
doaj   +1 more source

Protein-Engineered Coagulation Factors for Hemophilia Gene Therapy

Molecular Therapy: Methods & Clinical Development, 2019
Hemophilia A (HA) and hemophilia B (HB) are X-linked bleeding disorders due to inheritable deficiencies in either coagulation factor VIII (FVIII) or factor IX (FIX), respectively.
Benjamin J. Samelson-Jones, Valder R. Arruda   +1 more
doaj   +1 more source

Cell and Gene Therapies Manufacturing Challenges and Integrated Good Manufacturing Practices Solutions: A Lifecycle Perspective

Biotechnology and Bioengineering, EarlyView.
Lifecycle perspective on cell and gene therapy manufacturing challenges and enabling GMP solutions. ABSTRACT Cell and gene therapies (CGTs) are revolutionizing modern medicine; however, making these advanced medicines scalable and readily available to commercial manufacturers worldwide is a major challenge. The number of approved CGT products continues
Rajath Samaga, Udisha Singh, Sachin Dattram Pawar   +2 more
wiley   +1 more source

Christmas Disease (Hemophilia –B) – A Case Report

Bangabandhu Sheikh Mujib Medical University Journal, 2010
We report a 25 years old man developed Haemarthrosis of left hip joint with a history of recurrent swelling and pain in multiple joints and prolonged bleeding following minor trauma since childhood.
Md Rafiqul Alam, Mohammad Saiful Habib, Mohammad Arifur Rahman, Md Mizanur Rahman Khan, MA Jalil Chowdhury, Taimur AK Mahmud   +5 more
doaj   +1 more source

Hemophilia B: A Pain in the Back

Cureus, 2023
This case report describes an unusual manifestation of hemophilia B, in the form of a lateral chest wall hematoma. A 27-year-old hemophiliac male was found to have a lateral chest wall hematoma after presenting with back pain associated with localized chest wall swelling.
Vedire, Apurva, Upadrasta, Gautham, Imburgio, Steven, Johal, Anmol S, Hossain, Mohammad A   +4 more
openaire   +2 more sources

Hemophilia B families with the same mutation are often related a survey of the Swedish population

, 2012
Aim: To study if families with hemophilia B in Sweden carrying the same mutation are identical by descent (IBD) or the result of independent mutations (RM).
Kristianstad University., Ljung, R.,, Halldén, Christer,, Lidén, Annika,   +3 more
core   +1 more source

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

Genetic testing in hemophilia B diagnostics [PDF]

, 2015
Hemofilia B jest uwarunkowaną genetycznie skazą krwotoczną, spowodowaną brakiem lub zmniejszeniem syntezy osoczowego czynnika krzepnięcia IX (fIX). Powszechnie chorobę tę rozpoznaje się na podstawie wyników badań krzepnięcia osocza, przede wszystkim ...
Odnoczko, Edyta, Windyga, Jerzy
core   +1 more source