Results 51 to 60 of about 12,392,515 (266)

Time‐ and Temperature‐Dependent Response of Acquired FV Inhibitors: Implications for Laboratory Diagnosis and Clinical Management

Journal of Clinical Laboratory Analysis, EarlyView.
This in vitro workflow illustrates the time‐and temperature‐dependent behavior of acquired FV inhibitors. Patient plasma was centrifuged and serially diluted, followed by parallel incubation at room temperature and 37°C. Serial measurements of APTT mixing test and residual FV activity were recorded across incubation time points to monitor inhibitor ...
Lihua Zhang, Mingjie Li, Zhiqiang Xie, Junxiang Yao, Yingping Cao, Lihui Chen, Meihua Wang   +6 more
wiley   +1 more source

Clinical, humanistic, and economic burden of severe hemophilia B in the United States: Results from the CHESS US and CHESS US+ population surveys

Orphanet Journal of Rare Diseases, 2021
Background Hemophilia B is a rare congenital bleeding disorder that has a significant negative impact on patients’ functionality and health-related quality of life.
Tom Burke, Sohaib Asghar, Jamie O’Hara, Eileen K. Sawyer, Nanxin Li   +4 more
doaj   +1 more source

Understanding the Concept of Self‐Performed Ultrasound: A Scoping Review

Journal of Ultrasound in Medicine, EarlyView.
Self‐performed ultrasound is an emerging technology that facilitates adept self‐scans in untrained hands. Inspired by self‐performed imaging in space for more prompt diagnosis and therapy, it has the potential to accurately monitor chronic conditions remotely. However, the lack of supervision and physical restraints can hinder its usability.
Vy Do, Anson Chau, Elio Arruzza, Nayana Parange   +3 more
wiley   +1 more source

Preclinical evaluation of a next-generation, subcutaneously administered, coagulation factor IX variant, dalcinonacog alfa.

PLoS ONE, 2020
IntroductionThe rapid clearance of factor IX necessitates frequent intravenous administrations to achieve effective prophylaxis for patients with hemophilia B.
Timothy C Nichols, Howard Levy, Elizabeth P Merricks, Robin A Raymer, Martin L Lee   +4 more
doaj   +1 more source

Dental Management under General anesthesia of Children with Hemophilia A and Hemophilia B [PDF]

, 2018
Hemophilia is an X-linked herediatry disorder. Hemophilia A is a defiency of factor VIII and hemophilia B (Christmas disease) is a deficiency of factor IX. The most widely used classification is based on plasma procoagulant levels, with people 〈1% factor
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core   +1 more source

Patients with obesity have a higher risk of periprosthetic joint infection and more frequent polymicrobial infections after knee arthroplasty: A nationwide register‐based study from Denmark

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose To compare the 2‐year incidence of (1) revision due to periprosthetic joint infection (PJI) and (2) all‐cause revision after primary knee arthroplasty (KA) in patients with/without obesity and to compare the microbial profiles in early (≤ 90 days) and late (91–730 days) PJI.
Saber M. Aljuboori, Espen Jimenez‐Solem, Henrik Calum, Robin Christensen, Søren Overgaard   +4 more
wiley   +1 more source

Assessing the health-state utility values of rare disease-hemophilia B using EQ-5D-5L: a study based on the Chinese population

Orphanet Journal of Rare Diseases
Background Obtaining health-state utility values (HSUVs) aids in making scientific decisions in patient health management, especially for rare disease patients.
Chuchuan Wan, Haotao Li, Yulin Zhang, Qiqi Wang, Yiwen Huang, Tao Guan, Xiaoyu Xi   +6 more
doaj   +1 more source

The frequency of complications in a cohort of patients diagnosed with hemophilia A and hemophilia B receiving prophylactic treatment in Colombia: A retrospective noninterventional study.

PLoS ONE, 2023
IntroductionHemophilia A and B are disorders associated with the deficit of coagulation factors VIII and IX.ObjectiveWas to determine the incidence of complications in a cohort of patients diagnosed with moderate and severe hemophilia A or B under ...
Jorge E Machado Alba, Juan David Wilches-Gutierrez, Diana Rocio Arias-Osorio, Juan Manuel Reyes, Maria Lourdes Nakandakari, Harrison David Ospina-Arzuaga, Andres Gaviria-Mendoza, Natalia Castaño-Gamboa, Luis Fernando Valladales-Restrepo, Manuel E Machado-Duque   +9 more
doaj   +1 more source

Factors influencing in vivo transduction by recombinant adeno-associated viral vectors expressing the human factor IX cDNA. [PDF]

, 2001
Long-term expression of coagulation factor IX (FIX) has been observed in murine and canine models following administration of recombinant adeno-associated viral (rAAV) vectors into either the portal vein or muscle. These studies were designed to evaluate
Hanawa, H, Vanin, EF, Nathwani, AC, Zhou, JF, Davidoff, A, Nienhuis, AW   +5 more
core  

Hemophilia B: Molecular pathogenesis and mutation analysis

, 2015
Hemophilia B is an X-chromosome-linked inherited bleeding disorder primarily affecting males, but those carrier females with reduced factor IX activity (FIX:C) levels may also experience some bleeding.
Goodeve, A.C.
core   +1 more source