Results 211 to 220 of about 594,429 (316)

Antithrombotic therapy and risk of intracranial hemorrhage in patients with cerebral cavernous malformations: a multicenter propensity-matched cohort study. [PDF]

J Neurol
Salim HA, Lakhani DA, Hajjeh O, Essibayi MA, Chen H, Balar A, Adeeb N, Msherghi A, Jung M, Dmytriw AA, Colasurdo M, Malhotra A, Gandhi D, Yedavalli V, Ucisik F, Eldaya RW, Wintermark M.   +16 more
europepmc   +1 more source

Enhanced Intracellular Stability and Translation Efficiency of mRNA Drugs by a 2‐arm mRNA Platform

Advanced Science, EarlyView.
We constructed a 2‐arm mRNA, characterized by a unique topology formed through the dimerization of two mRNA 3’ tails. The 2‐arm mRNA improves 3’ tail stability and resistance to nuclease degradation, resulting in an intracellular half‐life of up to 65 h. This method substantially enhances the translation capacity of mRNA drugs.
Xucong Teng, Jiahao Lin, Qiushuang Zhang, Xiangdong Zhang, Yicong Dai, Jinghong Li   +5 more
wiley   +1 more source

The prognostic value of systemic inflammatory indices in elderly patients with spontaneous intracerebral hemorrhage. [PDF]

PLoS One
Jaradat Ö, Şahin B, Çalışkan HM.
europepmc   +1 more source

Secreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus

Advanced Science, EarlyView.
This study uncovers a conserved PIP2‐dependent secretory pathway of orbivirus NS3 that induces vascular leakage. Pharmacological disruption of PIP2‐NS3 interaction significantly reduces viral pathogenicity and provides protective efficacy in murine models, establishing PIP2‐mediated NS3 secretion as both a key virulence determinant and a promising ...
Junyong Guan, Dong Zhou, Ran Shao, Xing Liu, Jin Peng, Yingran Huang, Shuhui Qi, Cankun Xi, Menghang Wang, Bin Sun, Yinglin Qi, Xin Yin   +11 more
wiley   +1 more source

Genetically prioritized plasma proteins in intracerebral hemorrhage identified by Mendelian randomization with functional evidence of neuronal vulnerability. [PDF]

Am J Transl Res
Gu H, Bu YS, Niu JJ, Zhao HM, Li JH, Jiang XT, Wu ST, Xu GL, Yu S, Feng HX, Kong FZ, Wu GH.   +11 more
europepmc   +1 more source

Dual‐Network Protein Hydrogels Promote Rapid Hemostasis and Immune‐Regulated Scarless Tissue Regeneration

Advanced Science, EarlyView.
A dual‐network protein hydrogel substantially improves hemostasis and scar‐free healing.The adaptive network maintains intimate tissue contact while providing strong wet adhesion, tunable mechanics, and controlled degradation. Concurrent ROS scavenging and M2 polarization suppress fibrotic pathways, preventing scar formation.
Xiaomei Li, Guorui Zhang, Xinyue Wang, Zhongyu Liu, Ling Yang, Yuhan Bao, Min Wei, Yonglin Chen, Yanfei Ma, Wenbo Sheng, Bo Yu, Bin Li   +11 more
wiley   +1 more source

Imaging of the brain after aneurysmal subarachnoid hemorrhage one-year MRI outcome of surgical and edovascular treatment [PDF]

Bendel, Paula.
core  

Diagnostic Role of ChatGPT in the Detection of Intracranial Hemorrhage on Non-contrast Computed Tomography: A Retrospective Case-Control Study. [PDF]

Cureus
Shankar SJ, Sakalecha AK, Hemanth Kumar GS, Kamarthy P, Chincholikar S.   +4 more
europepmc   +1 more source