Results 241 to 250 of about 657,350 (312)

Spatial Transcriptomics Reveals a T Cell‐Mediated Microglial Activation Axis of Immune Checkpoint Inhibition‐Related Adverse Events in the Brain

Advanced Science, EarlyView.
Immune checkpoint inhibition (ICI) reshapes the hippocampal neuroimmune niche. Spatial transcriptomic profiling and human brain histological analyses identify neuroinflammation and altered neuronal and glial programs. Notably, T cell depletion prevents ICI‐driven microglial activation, establishing the T cell–microglia crosstalk axis as a driving ...
Devyani Swami, Sanad M. El‐Khatib, Suhas Sureshchandra, Elise Nguyen, Janaki Manoja Vinnakota, Robert Zeiser, Shivashankar Othy, Munjal M. Acharya   +7 more
wiley   +1 more source

Contemporary Epidemiology of Intracerebral Hemorrhage in Japan: A Population-Based Study from the Shiga Stroke and Heart Attack Registry.

Cerebrovasc Dis
Shitara S, Harada A, Tanaka-Mizuno S, Takashima N, Fujii T, Arima H, Urushitani M, Nozaki K, Miura K, Yoshida K.   +9 more
europepmc   +1 more source

Size and location of intracranial hemorrhage in acute stroke presentations: correlation with baseline NIHSS and relevance to direct-to-angiography workflows. [PDF]

Front Neurol
Nguyen A, Katan M, Guzman R, Soleman J, Nickel C, Psychogios MN, Brehm A.   +6 more
europepmc   +1 more source

An ATP‐Driven N Protein–DDX21 Molecular Switch Dynamically Controls SARS‐CoV‐2 RNA G‐Quadruplex Heterogeneity

Advanced Science, EarlyView.
An ATP‐driven molecular switch, comprising viral nucleocapsid (N) protein and host helicase DDX21, dynamically modulates SARS‐CoV‐2 RNA G‐quadruplex (G4) heterogeneity. These viral G4s feature non‐canonical ion‐dependence and act as energy‐sensitive structural checkpoints.
Ya‐Ting Zheng, Li‐Yan Zhai, Jie Jin, Qiu‐Ying Chen, Hang Fu, Xue‐Qian Sun, Ying Lu, Hui Li, Xi‐Miao Hou   +8 more
wiley   +1 more source

Safety of Subcutaneous Heparin in Patients Requiring External Ventricular Drains. [PDF]

Neurosurg Pract
Kucinski A, Looman CF, Felsing N, Kinachtchouk N, Adel JG.   +4 more
europepmc   +1 more source

A Recyclable and Biodegradable High‐Performance Piezoelectric Nanogenerator for Self‐Powered Biosensing and Assistive Human‐Machine Interaction

Advanced Science, EarlyView.
By exploiting multiscale hydrogen‐bonding interactions between HFPD and TOCNF, the composite simultaneously achieves a high piezoelectric coefficient (14.0 pC·N−1), outstanding flexibility (100 000 bending cycles), water‐assisted recyclability, excellent biodegradability, and sensitive wearable/implantable sensing for motion, speech, and Morse code ...
Tingshuai Luo, Tian Xiao, Luyu Zhang, Bailang Zhang, Shengchang Lu, He Xiao, Jianguo Li, Kai Liu, Chaoji Chen, Hui Wu   +9 more
wiley   +1 more source

Spiked Helmet Sign in the Early Post-Heart Transplantation Period: A Dramatic STEMI Mimic in a Structurally Normal Donor Heart. [PDF]

Ann Noninvasive Electrocardiol
Lima DRM, Segundo GSD, Targueta GP, Teixeira RTB, Meira AT, Athayde GAT.   +5 more
europepmc   +1 more source

SAT1‐Induced Spermidine Depletion Potentiates Food Allergy

Advanced Science, EarlyView.
Spermidine depletion, driven by upregulated spermidine/spermine N1‐acetyltransferase (SAT1), potentiates food allergy by promoting mast cell degranulation through autophagy suppression. SAT1 physically interacts with the long noncoding RNA Cdk19os to inhibit Atg5 and Atg7, disrupting autophagic flux.
Manman Liu, Beiyu Zhang, Junjuan Wang, Yue Jiang, Shiwen Han, Qianwei Wang, Lingyu Zeng, Jinfeng Wang, Huilian Che   +8 more
wiley   +1 more source

Interpreting comparative effectiveness of vacuum-assisted hemorrhage control and uterine balloon tamponade: The impact of temporal and clinical confounding. [PDF]

Acta Obstet Gynecol Scand
Mehta A, Deshpande HG, Shridevi K, Raina D, Srinivasan H.   +4 more
europepmc   +1 more source