Results 31 to 40 of about 650,492 (316)

A New Product of Bilirubin Degradation by H₂O₂ and Its Formation in Activated Neutrophils and in an Inflammatory Mouse Model

Biomolecules, 2022
Bilirubin (BR) is a tetrapyrrolic compound stemming from heme catabolism with diverse physiological functions. It can be oxidized by H2O2 to form several degradation products, some of which have been detected in vivo and may contribute to the ...
Fei-Fei Yu, Yao Yuan, Yan Ao, Li Hua, Wu Wang, Yiyi Cao, Jing Xi, Yang Luan, Shangwei Hou, Xin-Yu Zhang   +9 more
doaj   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Risk of Major Bleeding, Stroke/Systemic Embolism, and Death Associated With Different Oral Anticoagulants in Patients With Atrial Fibrillation and Severe Chronic Kidney Disease

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Patients with atrial fibrillation and severe chronic kidney disease have higher risks of bleeding, thromboembolism, and mortality. However, optimal anticoagulant choice in these high‐risk patients remains unclear.
Yunwen Xu, Shoshana H. Ballew, Alexander R. Chang, Lesley A. Inker, Morgan E. Grams, Jung‐Im Shin   +5 more
doaj   +1 more source

Molecular classification of hepatocellular adenomas: impact on clinical practice

Hepatic Oncology, 2018
Hepatocellular adenomas are rare benign liver tumors usually developing in young women using oral contraception. The two main complications are hemorrhage (10–20%) and malignant transformation into hepatocellular carcinoma (
Anne-Laure Védie, Olivier Sutter, Marianne Ziol, Jean-Charles Nault   +3 more
doaj   +1 more source

Intracranial Hemorrhage [PDF]

Emergency Medicine Clinics of North America, 2012
Intracranial hemorrhage refers to any bleeding within the intracranial vault, including the brain parenchyma and surrounding meningeal spaces. This article focuses on the acute diagnosis and management of primary nontraumatic intracerebral hemorrhage and subarachnoid hemorrhage in the emergency department.
J Alfredo, Caceres, Joshua N, Goldstein
openaire   +2 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

The pressure field model: a challenge to the conventional Starling and Guyton model of hemodynamic management

Frontiers in Anesthesiology
IntroductionEnsuring hemodynamic stability with adequate perfusion to vital organs is critical to the safe conduct of anesthesia. Recent advances in hemodynamic monitoring technologies allow pressure, flow, and resistance to be measured continuously ...
Stephen F. Woodford, Stephen F. Woodford, Laurence Weinberg, Laurence Weinberg, Lachlan F. Miles, Lachlan F. Miles, Ruth C. Marshall, Bernhard Riedel, Bernhard Riedel, Philip J. Peyton, Philip J. Peyton   +10 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Treatment Patterns of Cancer-associated Thrombosis in the Netherlands: The Four Cities Study

TH Open
Background Current guidelines recommend either low-molecular weight heparin (LMWH) or direct oral anticoagulants (DOACs) as first-line treatment in cancer-associated venous thromboembolism (VTE).
Fleur H.J. Kaptein, Noori A.M. Guman, Susan B. Lohle, Frederikus A. Klok, Albert T.A. Mairuhu, Pieter W. Kamphuisen, Nick Van Es, Menno V. Huisman   +7 more
doaj   +1 more source