Glanzmann's thrombasthenia – A rare case report of spontaneous gingival bleeding
Glanzmann's thrombasthenia is a rare congenital bleeding disorder which is associated with mutations in the genes encoding glycoproteins, gpIIb or gpIIIa resulting in platelet dysfunction.
Vijayalakshmi Venkat +2 more
doaj +1 more source
Safety and tolerability of NXY-059 for acute intracerebral hemorrhage: the CHANT trial [PDF]
<p><b>Background and Purpose:</b> NXY-059 is a free radical-trapping neuroprotectant developed for use in acute ischemic stroke. To facilitate prompt administration of treatment, potentially before neuroimaging, we investigated the ...
Ahlberg, G. +12 more
core +1 more source
Relationship of blood pressure, antihypertensive therapy, and outcome in ischemic stroke treated with intravenous thrombolysis: retrospective analysis from Safe Implementation of Thrombolysis in Stroke-International Stroke Thrombolysis Register (SITS-ISTR) [PDF]
<p><b>Background and Purpose:</b> The optimal management of blood pressure (BP) in acute stroke remains unclear. For ischemic stroke treated with intravenous thrombolysis, current guidelines suggest pharmacological intervention if ...
Ahmed, N. +4 more
core +1 more source
Radiologic Imaging in Meckel Diverticulum Complications
In 1809, Johann Friedrich Meckel the Younger described the most common congenital small bowel anomaly, which was named after him; however, the radiologic manifestations and interventional guidelines related to this entity are still limited to a few large-
Erin Leslee Dames +1 more
doaj +1 more source
Identification of erythroferrone as an erythroid regulator of iron metabolism. [PDF]
Recovery from blood loss requires a greatly enhanced supply of iron to support expanded erythropoiesis. After hemorrhage, suppression of the iron-regulatory hormone hepcidin allows increased iron absorption and mobilization from stores.
Ganz, Tomas +5 more
core +1 more source
Spectrophotometry for cerebrospinal fluid pigment analysis [PDF]
The use of spectrophotometry for the analysis of the cerebrospinal fluid (CSF) is reviewed. The clinically relevant CSF pigments--oxyhemoglobin and bilirubin--are introduced and discussed with regard to clinical differential diagnosis and potentially ...
Keir, G., Petzold, A., Sharpe, L.T.
core +1 more source
IntroductionClazosentan, a selective endothelin receptor subtype A antagonist, reduces vasospasm-related morbidity and all-cause mortality following aneurysmal subarachnoid hemorrhage (SAH) in the Japanese population, as demonstrated by a recent ...
Hiroyuki Sakata +15 more
doaj +1 more source
Peribulbar anesthesia in 750 patients treated with oral anticoagulants
AIM: To check the safety of continuation of oral anticoagulants in ophthalmic procedures requiring a peribulbar anesthesia.METHOD:A prospective case control study included 750 patients with oral anticoagulants in group A and 750 patients who had never ...
Emile Calenda +3 more
doaj +1 more source
Intracerebral Hemorrhage and Ischemic Stroke of Different Etiologies Have Distinct Alternatively Spliced mRNA Profiles in the Blood: a Pilot RNA-seq Study. [PDF]
Whole transcriptome studies have used 3'-biased expression microarrays to study genes regulated in the blood of stroke patients. However, alternatively spliced messenger RNA isoforms have not been investigated for ischemic stroke or intracerebral ...
Ander, Bradley P +8 more
core +2 more sources
C-Jun N-terminal kinase 2 promotes liver injury via the mitochondrial permeability transition after hemorrhage and resuscitation [PDF]
Hemorrhagic shock leads to hepatic hypoperfusion and activation of mitogen-activated stress kinases (MAPK) like c-Jun N-terminal kinase (JNK) 1 and 2. Our aim was to determine whether mitochondrial dysfunction leading to hepatic necrosis and apoptosis ...
Czerny, Christoph +6 more
core +2 more sources

