Results 41 to 50 of about 657,350 (312)

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Metabolic vulnerability index and Life’s Essential 8 with risk of major adverse cardiovascular events

npj Cardiovascular Health
The metabolic vulnerability index (MVX) captures metabolic-inflammatory vulnerability, but its joint relevance with Life’s Essential 8 (LE8) for major adverse cardiovascular events (MACE) is unclear.
Xiaojie Wang, Yanhui Gao, Gregory Y. H. Lip, Jianwen Guo, Junguo Zhang   +4 more
doaj   +1 more source

Hemorrhagic Shock

New England Journal of Medicine, 2018
Contains fulltext : 196113.pdf (Publisher’s version ) (Open Access)
Timmermans, K., Slagt, C., Kox, M.
openaire   +9 more sources

Occurrence of vasospasm and infarction in relation to a focal monitoring sensor in patients after SAH: placing a bet when placing a probe? [PDF]

, 2013
Introduction: Vasospastic brain infarction is a devastating complication of aneurysmal subarachnoid hemorrhage (SAH). Using a probe for invasive monitoring of brain tissue oxygenation or blood flow is highly focal and may miss the site of cerebral ...
Ulrich, Christian T., Setzer, Matthias, Christian T Ulrich, Hartmut Vatter, Juergen Beck, Matthias Setzer, Christian Fung, Beck, Jürgen, Seifert, Volker, Volker Seifert, Güresir, Erdem Özer, Gueresir, Erdem, Raabe, Andreas, Fung, Christian, Vatter, Hartmut, Erdem Gueresir, Andreas Raabe, Seifert Volker, Beck Juergen, Vatter H, Vatter Hartmut, Fung Christian, Ulrich CT, Gueresir E, Gueresir Erdem, Fung C, Raabe A, Raabe Andreas, Ulrich Christian T., Seifert V, Setzer Matthias, Beck J, Setzer M   +32 more
core   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

CEREBRAL HEMORRHAGE. [PDF]

Journal of the American Medical Association, 1899
n ...
openaire   +2 more sources

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Plant-derived nanovesicles: the intelligent nanoplatforms for therapeutics and drug delivery

Journal of Nanobiotechnology
Extracellular vesicles (EVs) are cell-secreted phospholipid bilayer vesicles that play a key role in intercellular communication by transporting molecular cargo and engaging in surface-level signaling.
Shuang Du, Dan Jia, Guohui Liang, Yonghui Dou   +3 more
doaj   +1 more source

A New Product of Bilirubin Degradation by H₂O₂ and Its Formation in Activated Neutrophils and in an Inflammatory Mouse Model

Biomolecules, 2022
Bilirubin (BR) is a tetrapyrrolic compound stemming from heme catabolism with diverse physiological functions. It can be oxidized by H2O2 to form several degradation products, some of which have been detected in vivo and may contribute to the ...
Fei-Fei Yu, Yao Yuan, Yan Ao, Li Hua, Wu Wang, Yiyi Cao, Jing Xi, Yang Luan, Shangwei Hou, Xin-Yu Zhang   +9 more
doaj   +1 more source

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source