Results 31 to 40 of about 804,565 (305)

Prophylactic management of cerebral vasospasm with clazosentan in real clinical practice: a single-center retrospective cohort study

Frontiers in Neurology
IntroductionClazosentan, a selective endothelin receptor subtype A antagonist, reduces vasospasm-related morbidity and all-cause mortality following aneurysmal subarachnoid hemorrhage (SAH) in the Japanese population, as demonstrated by a recent ...
Hiroyuki Sakata, Hiroyuki Sakata, Atsushi Kanoke, Hiroki Uchida, Shinya Haryu, Shunsuke Omodaka, Naoto Kimura, Masahiro Yoshida, Kuniyasu Niizuma, Kuniyasu Niizuma, Kuniyasu Niizuma, Kuniyasu Niizuma, Teiji Tominaga, Teiji Tominaga, Hidenori Endo, Hidenori Endo   +15 more
doaj   +1 more source

Crotalus atrox venom preconditioning increases plasma fibrinogen and reduces perioperative hemorrhage in a rat model of surgical brain injury. [PDF]

, 2017
Perioperative bleeding is a potentially devastating complication in neurosurgical patients, and plasma fibrinogen concentration has been identified as a potential modifiable risk factor for perioperative bleeding.
Applegate, Richard, Bull, Brian S, Gren, Eric CK, Hay, Karen L, Hayes, William K, Kelln, Wayne, Kim, Cherine H, Lekic, Tim, McBride, Devin W, Raval, Ronak, Sherchan, Prativa, Tang, Jiping, Zhang, John H   +12 more
core   +1 more source

Clinical outcome after first and recurrent hemorrhage in patients with untreated brain arteriovenous malformation [PDF]

, 2006
Background and Purpose: The morbidity from spontaneous hemorrhage of untreated brain arteriovenous malformations (AVM) is not well described. Methods: The 241 consecutive AVM patients (mean age 3716 years, 52% women) from the prospective Columbia AVM ...

core  

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

Survival Outcomes and Complications Among Canadian Children With Retinoblastoma: A Population‐Based Report From CYP‐C

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Retinoblastoma (RB) is the most common pediatric ocular cancer, yet population‐based data on survival and risk factors remain limited. This study aimed to describe survival in a large national RB cohort and identify predictors of death and complications.
Samuel Sassine, Ofélie Trudeau‐Ferrin, Caroline Laverdière, Patrick Hamel, Rosanne Superstein, Bénédicte Koukoui, Carole Provost, Paul C. Nathan, Vijay Ramaswamy, Furqan Shaikh, Brenda Gallie, Ashwin Mallipatna, Stephanie Kletke, Helen Dimaras, Hallie Coltin   +14 more
wiley   +1 more source

Randomized, open-label, phase 1/2a study to determine the maximum tolerated dose of intraventricular sustained release nimodipine for subarachnoid hemorrhage (NEWTON [Nimodipine Microparticles to Enhance Recovery While Reducing Toxicity After Subarachnoid Hemorrhage]) [PDF]

, 2016
BACKGROUND AND PURPOSE—: We conducted a randomized, open-label, phase 1/2a, dose-escalation study of intraventricular sustained-release nimodipine (EG-1962) to determine safety, tolerability, pharmacokinetics, and clinical effects in aneurysmal ...
Aldrich, Francois, Diringer, Michael N, Etminan, Nima, Faleck, Herbert J, Hanggi, Daniel, Hoh, Brian L, Macdonald, R. Loch, Mayer, Stephen A, Mocco, J, Newton Investigators,, Steiger, Hans Jakob   +10 more
core   +3 more sources

Sirolimus for Extracranial Arteriovenous Malformations: A Scoping Review of the Evidence in Syndromic and Non‐Syndromic Cases

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson, Ingrid Winship, Gary Hammerschlag, Laura Scardamaglia   +3 more
wiley   +1 more source

Cerebral Arteriovenous Malformations

Pediatric Neurology Briefs, 1994
A retrospective analysis of 62 children with cerebral arteriovenous malformations (AVM) seen over 17 years is reported from Hospital B, Lille, France.
J Gordon Millichap
doaj   +1 more source

Drug-Induced Hypocoagulation: Results of Emergency Surgical Treatment

Креативная хирургия и онкология, 2020
Introduction. The drug-induced hemorrhagic syndrome in surgical patients has become a serious problem of contemporary surgery, complicating the choice of treatment tactics and often leading to death.
A. G. Hasanov, M. A. Nurtdinov, A. F. Badretdinov   +2 more
doaj   +1 more source

A New Product of Bilirubin Degradation by H₂O₂ and Its Formation in Activated Neutrophils and in an Inflammatory Mouse Model

Biomolecules, 2022
Bilirubin (BR) is a tetrapyrrolic compound stemming from heme catabolism with diverse physiological functions. It can be oxidized by H2O2 to form several degradation products, some of which have been detected in vivo and may contribute to the ...
Fei-Fei Yu, Yao Yuan, Yan Ao, Li Hua, Wu Wang, Yiyi Cao, Jing Xi, Yang Luan, Shangwei Hou, Xin-Yu Zhang   +9 more
doaj   +1 more source