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Pathogenesis of the Viral Hemorrhagic Fevers
Annual Review of Pathology: Mechanisms of Disease, 2013Four families of enveloped RNA viruses, filoviruses, flaviviruses, arenaviruses, and bunyaviruses, cause hemorrhagic fevers. These viruses are maintained in specific natural cycles involving nonhuman primates, bats, rodents, domestic ruminants, humans, mosquitoes, and ticks.
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Viral hemorrhagic fevers (VHF) are acute febrile viral infectious diseases of humans, characterized by multisystem involvement and evidence of microvascular leak, with or without hemorrhage. This clinical syndrome is associated with more than 20 viruses, all of which are lipidenveloped viruses with RNA genomes.
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