Results 41 to 50 of about 1,342 (174)

A phase 1/2 safety and efficacy study of TAK‐754 gene therapy: The challenge of achieving durable factor VIII expression in haemophilia A clinical trials

Haemophilia, Volume 31, Issue 1, Page 108-117, January 2025.
Abstract Introduction Haemophilia A is an X‐linked bleeding disorder resulting from a deficiency of factor VIII (FVIII). To date, multiple gene therapies have entered clinical trials with the goal of providing durable haemostatic protection from a single dose. TAK 754 (BAX 888) is an investigational AAV8‐based gene therapy containing a FVIII transgene.
John Chapin, Maria Teresa Álvarez Román, Mila Ayash‐Rashkovsky, Dorothee Diogo, Jon Kenniston, Francisco‐Jose Lopez‐Jaime, Caterina Maggiore, María‐Eva Mingot‐Castellano, Kavitha Rajavel, Antoine Rauch, Sophie Susen, Marcin von Grotthuss, Matt Wagoner, Qin Wang   +13 more
wiley   +1 more source

Alterações da hemostasia em crianças submetidas a cirurgia cardíaca com circulação extracorpórea [PDF]

Arquivos Brasileiros de Cardiologia, 1998
OBJETIVO: Avaliar as alterações de hemostasia encontradas em crianças submetidas a cirurgia cardíaca com circulação extracorpórea (CEC). MÉTODOS: Estudamos 17 crianças no pré e pós-operatório (PO) imediato, no 1° PO e entre o 4º e 7º PO, analisando o ...
Fernanda Maria Rebouças da Costa Silveira, Dayse Maria Lourenço, Miguel Maluf, Werther B. Carvalho, Enio Buffolo, Antonio Carlos Carvalho   +5 more
doaj   +1 more source

Cystathionine β-synthase and methylenetetrahydrofolate reductase mutations in Mexican individuals with hyperhomocysteinemia

SAGE Open Medicine, 2020
Background: Hyperhomocysteinemia, a thrombotic risk factor, may have several causes. Among the genetic causes of hyperhomocysteinemia, there are polymorphisms in the enzymes methylenetetrahydrofolate reductase (C677T) and cystathionine β-synthase (C699T,
Anahi Guadalupe Figueroa-Torres, Lisneth Osiris Matias-Aguilar, Erika Coria-Ramirez, Edmundo Bonilla-Gonzalez, Humberto Gonzalez-Marquez, Isabel Ibarra-Gonzalez, Jose Rubicel Hernandez-Lopez, Jesus Hernandez-Juarez, Victor Manuel Dominguez-Reyes, Irma Isordia-Salas, Abraham Majluf-Cruz   +10 more
doaj   +1 more source

Efficacy and safety of robotic liver surgery for the elderly: A propensity‐score matched analysis of short‐term outcomes with open liver surgery at a single center in Denmark

Journal of Hepato-Biliary-Pancreatic Sciences, Volume 31, Issue 9, Page 625-636, September 2024.
Fukumori and colleagues compared the short‐term results of robotic liver surgery with those of conventional open liver surgery in elderly patients aged 70 years and over and used propensity score‐matched analysis to assess safety and efficacy. Robotic liver surgery can be safely performed in patients aged 70 years and older.
Daisuke Fukumori, Christoph Tschuor, Takashi Hamada, Luit Penninga, Jens Hillingsø, Lars Bo Svendsen, Peter Nørgaard Larsen   +6 more
wiley   +1 more source

MAIN BLOOD SERUM METABOLITES RESPONSIBLE FOR THE DISCRIMINATION OF HOSPITALIZED PATIENTS WITH MODERATE SYMPTOMS WITH OR WITHOUT COVID-19

Hematology, Transfusion and Cell Therapy, 2021
Introduction: The variation in human blood serum metabolites resulting from an infection can assist in understanding mechanisms of pathogen action and body response and improve diagnosis. Aim: To map serum signatures of hospitalized symptomatic patients,
LG Martins, SS Martins, ES Braga, D Stanisic, SAL Montalvão, LQ Silva, SC Huber, T Diaz, C Wroclawski, CC Filho, L Tasic, JM Annichino-Bizzacchi   +11 more
doaj   +1 more source

Increased matrix metalloproteinase‐2 in ligamentum flavum hypertrophy and the regulation of MMP‐2/TIMPs by elastin‐derived peptides

Journal of Orthopaedic Research, Volume 42, Issue 9, Page 2061-2071, September 2024.
Abstract The study aimed to examine matrix metalloproteinase‐2 (MMP‐2) expression in a rat ligamentum flavum (LF) hypertrophy model in vivo, and the effect of elastin‐derived peptides (EDPs) on MMP‐2 and tissue inhibitors of metalloproteinases (TIMPs) in rat LF cells in vitro.
Wen‐Hai Zhuo, Hwee Weng Dennis Hey, Wing Moon Raymond Lam, Xiaoyun Chloe Chan, Loo Hoey Lit, Yong Soon Chiong, Hee‐Kit Wong   +6 more
wiley   +1 more source

Humanistic burden of haemophilia A without inhibitors: A cross‐sectional analysis of the HemoLIFE study

Haemophilia, Volume 30, Issue 4, Page 950-958, July 2024.
Abstract Aim To evaluate the impact of haemophilia A without inhibitors on humanistic outcomes in patients and caregivers. Herein, we report a cross‐sectional analysis of the baseline data of persons with haemophilia (PWH) participating in the prospective study HEMOLIFE. Methods These data are part of a prospective, observational, and multicentre study
María Teresa Álvarez‐Román, Ramiro Jose Nuñez Vazquez, Olga Benitez Hidalgo, Laura Quintana Paris, Laura Entrena Ureña, Francisco Jose Lopez Jaime, Hortensia la De Corte‐Rodríguez, María García Dasí, Pau Bosch, María Eva Mingot Castellano, Itziar Guerra Garaeta, Inmaculada Soto‐Ortega   +11 more
wiley   +1 more source

Medidas em diagramas tempo-frequência aplicado na caracterização de transições de estado com o uso de sinais ultra-sônicos espalhados do processo de coagulação sanguínea: Uma análise numérica.

Semina: Ciências Exatas e Tecnológicas, 2004
Este trabalho apresenta uma forma alternativa de análise do sinal obtido a partir do Método Ultra-Sônico (US) no estudo das alterações do plasma sanguíneo em processo de coagulação.
Carlos Dias Maciel, Lana Ribeiro da Fonseca Monteiro   +1 more
doaj   +1 more source

Hemostasia compresiva con balón vs. inyección de epinefrina en sangrado inmediato postesfinterotomía

Endoscopia, 2021
Introducción: El sangrado postesfinterotomía tiene una incidencia variable, desde un 0.3-2% e incrementándose hasta un 9.6% en algunos casos, y una mortalidad del 0.04%.
Lourdes G. Pedroza-Terán, Edgar G. Beltrán-Campos, Alejandra Arellano-Pérez, Yolanda Zamorano-Orozco, Víctor H. Ahumada-Topete   +4 more
doaj   +1 more source

Laryngeal microsurgery under Transnasal Humidified Rapid Insufflation Ventilatory Exchange

OTO Open, Volume 8, Issue 2, April–June 2024.
Abstract Objective Since 2015, Transnasal Humidified Rapid Insufflation Ventilatory Exchange (THRIVE) has been used in general anesthesia for preoxygenation or difficult exposure airway management. Its use offers new opportunities in laryngology. THRIVE increases apnea time and frees the access to the upper airway.
Tiffany Rigal, Robin Baudouin, Marta Circiu, Florent Couineau, Jérôme Lechien, Lise Crevier‐Buchman, Morgan Le Guen, Stéphane Hans   +7 more
wiley   +1 more source