Targeting the Menin–KMT2A interaction in leukemia: Lessons learned and future directions
Abstract Chromosomal rearrangements involving the Mixed Lineage Leukemia gene (MLL1, KMT2A) are defining a genetically distinct subset in about 10% of human acute leukemias. Translocations involving the KMT2A‐locus at chromosome 11q23 are resulting in the formation of a chimeric oncogene, where the N‐terminal part of KMT2A is fused to a variety of ...
Florian Perner+3 more
wiley +1 more source
Contrast-Enhanced Ultrasound-Guided Microwave Ablation for Iatrogenic Hepatic Hemorrhage: A Feasibility Study on Precision Hemostasis. [PDF]
Li Q+6 more
europepmc +1 more source
HLA alloimmunization and blood requirements in orthotopic liver transplantation. [PDF]
Duquesnoy, R+5 more
core
Therapeutic targeting of chromatin alterations in leukemia and solid tumors
Abstract Alterations in chromatin conformation and post‐translational modification of histones have become increasingly recognized as critical drivers of cancer development, progression, and therapy resistance. Recent advances in drug development have led to the establishment of several highly selective small molecule inhibitors, several of which are ...
Florian Perner+7 more
wiley +1 more source
Aorto-Esophageal Fistula Caused by Vascular Malformation: A Case Description and an Analysis of the Literature. [PDF]
Zhang W, Hu X, Yu J.
europepmc +1 more source
Aprotinin in orthotopic liver transplantation [PDF]
Bechstein, W. O.+8 more
core +1 more source
Obstetrics and gynecology devices designed for low‐ and middle‐income countries: A narrative review
Abstract There are many barriers contributing to poor health outcomes for women in low‐ and middle‐income countries (LMICs), one of which is the lack of necessary medical devices. Presently, the development of various kinds of devices intended to improve women's health outcomes specifically in LMICs remains underrepresented in the literature; therefore,
Dhanalakshmi Thiyagarajan+2 more
wiley +1 more source
Abstract Background Preoperative prophylactic balloon occlusion (PPBO) of internal iliac arteries (IIAs) in placenta previa and placenta accreta spectrum (PAS) has been widely used as a preventive adjuvant technique to reduce blood loss and to preserve fertility. Nevertheless, the efficacy of PPBO is based primarily on retrospective studies.
Rula Iskander+4 more
wiley +1 more source
Ostene® on, bleeding off: Discussing the indications and benefits of a water-soluble bone hemostasis material. [PDF]
Pinto FCM.
europepmc +1 more source