Results 51 to 60 of about 7,856 (151)

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, Volume 16, Issue 5, Page 944-965, May 2026.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Intensive Chemotherapy With or Without Midostaurin in Adults ≥ 60 Years Old With FLT3‐Mutated AML: A FILO‐DATAML‐PETHEMA Real‐World Study

American Journal of Hematology, Volume 101, Issue 5, Page 949-960, May 2026.
ABSTRACT The addition of midostaurin (MIDO) to intensive chemotherapy (IC) improves survival in younger adults with FLT3‐mutated acute myeloid leukemia (AML); however, real‐world data in elderly patients (≥ 60 years) are limited. This large, retrospective, multicenter study from three European registries (PETHEMA, FILO, DATAML) evaluated MIDO+IC (n ...
Gaspar Aspas Requena, Pau Montesinos, Emilie Bérard, Sarah Bertoli, Rebeca Rodríguez‐Veiga, Celestine Simand, Laura Torres, Pierre Peterlin, Mar Tormo, Rudy Birsen, Juan Miguel Bergua‐Burgues, Emmanuelle Tavernier, Teresa Bernal del Castillo, Martin Carré, Cristina Gil, Adrien Contejean, Eduardo Rodríguez‐Arbolí, Corentin Orvain, Carlos Rodríguez‐Medina, Lauren Veronese, Maria Jose Sayas Lloris, Eric Delabesse, Josefina Serrano, Ariane Mineur, María García‐Fortes, Romain Guieze, Maria Luz Amigo, Arnaud Pigneux, Lorenzo Algarra Algarra, Christian Recher, Pierre‐Yves Dumas, David Martínez‐Cuadrón   +31 more
wiley   +1 more source

Guidelines On The Diagnosis And Treatment For Acute Promyelocytic Leukemia: Associação Brasileira De Hematologia, Hemoterapia E Terapia Celular Guidelines Project: Associação Médica Brasileira - 2013

, 2015
[No abstract available]3617192Swerdlow, S.H., Campo, E., Harris, N.L., Jaffe, E.S., Pileri, S.A., Stein, H., (2008) WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues, , IARC: LyonRohr, S.S., Pelloso, L.A., Borgo, A., de Nadai, L.C ...
Melo R.A.M., Rohr S., Firmato A.B., Bittencourt R., Chauffaille M.L., Fagundes E.M., Pagnano K.B.B., Rego E.M., Jacomo R.H., Bernardo W.   +9 more
core   +1 more source

Adherence to Clotting Factor Prophylaxis in Adolescent and Adult Males With Haemophilia

Haemophilia, Volume 32, Issue 3, Page 739-747, May/June 2026.
ABSTRACT Introduction Clotting factor prophylaxis remains the most prescribed standard‐of‐care treatment for people with haemophilia (PwH). Prophylaxis prevents bleeds, joint damage, and improves quality of life (QoL). Its success depends on treatment adherence, consisting of socioeconomic, behavioural, and disease‐ or therapy‐related factors.
Nathália Martins Beserra, Ricardo Mesquita Camelo, Alice Oliver Rosa Sacramento, Eliziane Souza Nascimento, Rosângela Pinheiro Gonçalves Machado, Clarissa Maria Gonçalves Machado, Suzzy Maria Carvalho Dantas, Samuel Gonçalves Machado da Rocha, Luany Elvira Mesquita Carvalho, Romélia Pinheiro Gonçalves Lemes   +9 more
wiley   +1 more source

Equipe de enfermagem e sua inserção em hemoterapia / Nursing team and its insertion in hemotherapy [PDF]

, 2020
Objetivo: Descrever como as equipes de enfermagem que atuam em unidades de hemoterapia têm ampliado seu conhecimento científico perante as dificuldades encontradas ao exercer sua prática nos serviços de hemoterapia e revelar o impacto da capacitação ...
Mesquita, Gustavo Nunes de, Oliveira, Julia Gonçalves, Naves, Ana Lúcia Alves, Ribeiro, Lilian Reinaldi, Ribeiro, Luiz Henrique dos Santos, Enfermeira, Daniela Marcondes Gomes, Silva, Laisa Marcato Souza da, Neves, Keila do Carmo   +7 more
core   +1 more source

Digital PCR‐based non‐invasive prenatal diagnosis should be considered in the evolving diagnostic pathway for sickle cell disease

HemaSphere, Volume 10, Issue 8, August 2026.
Paloma Ropero, Fernando Ataúlfo González, Miguel Gómez, Jorge M. Nieto, Ana Villegas, Celina Benavente   +5 more
wiley   +1 more source

The Effect of Photobiomodulation in the Management of Leg Ulcers in Sickle Cell Disease: A Systematic Review

International Wound Journal, Volume 23, Issue 5, May 2026.
ABSTRACT Leg ulcer (LU) is a chronic complication of sickle cell disease (SCD), characterised by intense pain, treatment resistance and a high impact on the patient's quality of life (QoL), representing a significant public health challenge. Clinical management involves multifaceted approaches; however, the variability in response to conventional ...
Jéssica Eutímio de Carvalho Silva, Caroline Conceição da Guarda, Luciana Magalhães Fiuza, Teresa Cristina Cardoso Fonseca, Marilda de Souza Gonçalves, Milena Magalhães Aleluia   +5 more
wiley   +1 more source

Prospective validation of podoplanin expression as a diagnostic biomarker of acute promyelocytic leukemia

Cytometry Part B: Clinical Cytometry, Volume 110, Issue 2, Page 128-133, March 2026.
Abstract Acute promyelocytic leukemia (APL) is a medical emergency that needs immediate diagnosis and treatment. Podoplanin, a transmembrane glycoprotein that binds CLEC‐2 on platelets, was recently demonstrated to be abnormally expressed in leukemic blasts in APL, as opposed to other forms of AML, in a study using thawed primary cells.
Camilla Maria de Alencar Saraiva, Carla Roberta Peachazepi Moraes, Bruno Kosa Lino Duarte, Gislaine Borba Oliveira, Herton Luiz Alves Sales Filho, Paula de Melo Campos, Sara Teresinha Olalla Saad, Erich Vinicius De Paula   +7 more
wiley   +1 more source

Perfil sorológico e demográfico dos doadores de sangue do estado de Santa Catarina, no período janeiro à dezembro de 2010 [PDF]

, 2011
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Saúde Coletiva, Florianópolis, 2011Estudo descreve o perfil sorológico, demográfico e geográfico dos doadores de sangue do Estado ...
Saraiva, Suélen dos Santos
core  

Descarte de bolsas de sangue devido à reatividade para doença de Chagas em um laboratório de triagem sorológica de doadores em Porto Alegre-RS Disposal of blood units due to reactivity for Chagas' disease in a blood donor serological screening laboratory in Porto Alegre, Brazil

Revista Brasileira de Hematologia e Hemoterapia, 2009
A transmissão transfusional (DCT) da doença de Chagas foi aventada nos anos 30 e comprovada nos anos 50. Inicialmente a sorologia pré-transfusional não era obrigatória e nas décadas seguintes os testes foram aperfeiçoados com técnicas mais adaptadas e ...
Douglas B. Fitarelli, Joel F. Horn
doaj