Results 81 to 90 of about 974,195 (308)

A Rare De Novo Missense Mutation in IFT122 Confers a Genetic Susceptibility Factor of Idiopathic Pediatric Uveitis Via Trio‐based Whole‐Exome Sequencing

Advanced Science, EarlyView.
A rare de novo IFT122‐A773E variant is identified in idiopathic pediatric uveitis and shown to exacerbate retinal inflammation and barrier dysfunction. Mechanistically, the variant enhances IFT43 interaction, elevates calcium signaling, and activates the MEK/ERK/FRA1 axis, revealing a previously unrecognized cilia‐associated pathway that may increase ...
Qian Zhou, Jiaxing Huang, Yilin Wang, Xingran Li, Xianyang Liu, Lingyu Dai, Hongshun Li, Qingfeng Wang, Jiangyi Liu, Guannan Su, Wanyun Zhang, Yang Deng, Qingfeng Cao, Yujie Lai, Xiang Luo, Changwei Huang, Ling Chen, Shengping Hou, Peizeng Yang   +18 more
wiley   +1 more source

Programmable Paracrine‐Mimetic Microneedle System for Temporal Regulation of Cardiac Repair

Advanced Science, EarlyView.
Temporal signaling is encoded into a programmable paracrine‐mimetic microneedle patch via tris(2,2'‐bipyridyl)dichlororuthenium(II) hexahydrate/sodium persulfate‐tuned hydrogel microparticles that deliver TGF‐β, IGF‐1, and VEGF over phase‐matched 7‐, 14‐, and 28‐day windows.
Yichen Dai, Pengchong Du, Zhaoyang Wang, Surilige, Rangga Fokta, Renjian Tan, Xiqing Zhao, Shuoyi Zhang, Yuecheng Wang, Yixin Zhang, Ziliang Fu, Rui Gong, Cheng Jiang, Yisheng He, Qiguang Wang, Renke Li, Khoon Lim, Junnan Tang, Xiaolin Cui   +18 more
wiley   +1 more source

Construction and Validation of New Nomograms to Predict Risk and Prognostic Factors of Breast Cancer Bone Metastasis in Asian Females: A Population-Based Retrospective Study

International Journal of General Medicine, 2021
Junsen Deng,1,* Di Zhang,2,* Wenming Zhang,1 Junhui Li2 1Department of Orthopedics Surgery, Luoyang Orthopedic Hospital of Henan Province, Orthopedic Hospital of Henan Province, Zhengzhou, 45000, Henan, People’s Republic of China; 2Department of ...
Deng J, Zhang D, Zhang W, Li J
doaj  

USP30‐Mediated Deubiquitination of PEX5 Suppresses Pexophagy to Drive Tubular Injury in Diabetic Kidney Disease

Advanced Science, EarlyView.
USP30 accumulation in diabetic renal tubular epithelial cells deubiquitinates PEX5, suppresses pexophagy, and drives dysfunctional peroxisome accumulation and tubular injury. USP30 depletion restores PEX5 ubiquitination and pexophagy, improves peroxisomal function, and alleviates tubular damage, highlighting USP30 as a therapeutic target in diabetic ...
Jia Li, Chaoyang Hua, Guangpu Li, Furong Zhai, Jingjing Ren, Shaokang Pan, Qi Feng, Jianguo Wen, Dongwei Liu, Zhangsuo Liu, Jiayu Duan   +10 more
wiley   +1 more source

Monthly distribution of reported FTLS cases: Henan Province, China, January 2011 to December 2012.

, 2014
Monthly distribution of reported FTLS cases: Henan Province, China, January 2011 to December 2012.
Kai Kang (195645), Guohua Liu (506590), Haomin Chen (195651), Bianli Xu (149218), Xueyong Huang (149227), Xiaoning Hu (535723), Yanhua Du (195641), Hongxia Ma (102711), Li Zhang (8200), Aiguo You (535724), Haifeng Wang (188956)   +10 more
core   +1 more source

Giant Magneto‐Optical Effects in Two‐Dimensional Flat‐Band Antiferromagnets

Advanced Science, EarlyView.
RuOCl2${\rm RuOCl}{_2}$, a two‐dimensional antiferromagnet, hosts energy bands with pronounced directional flatness. This study demonstrates that the flat‐band‐induced optical transitions yield strongly anisotropic absorption and a record‐large magneto‐optical Schafer–Hubert effect, alongside exceptional linear dichroism exceeding 50%.
Ping Yang, Wanxiang Feng, Siyuan Liu, Shan Guan, Liwei Wen, Wei Jiang, Gui‐Bin Liu, Yugui Yao   +7 more
wiley   +1 more source

Clinical Characteristics of Malignant Pulmonary Sclerosing Pneumocytoma Based on a Study of 46 Cases Worldwide

Cancer Management and Research, 2022
Weidong Zhang,1 Dong Cui,1 Yaqian Liu,2 Kefeng Shi,1 Xia Gao,3 Rulin Qian1 1Department of Thoracic Surgery, Henan Provincial Chest Hospital, Zhengzhou City, Henan Province, People’s Republic of China; 2Medical Records and Statistics Room, Henan ...
Zhang W, Cui D, Liu Y, Shi K, Gao X, Qian R   +5 more
doaj  

The CXCL5/CXCR2 Axis Attenuates Ferroptosis in Intrahepatic Cholangiocarcinoma Through the Positive Feedback Loop Between PTGS2 Transcriptional Activation and Neutrophil Recruitment

Advanced Science, EarlyView.
The CXCL5/CXCR2 axis directly inhibits ferroptosis in ICC cells by activating the NF‐κB/PTGS2 pathway. Meanwhile, the CXCL5/CXCR2 axis recruits N2 TANs, and the activated PTGS2 promotes the secretion of TNF‐α from the recruited N2 TANs via the CCL2/CCL7/CCR2 pathway, thereby activating the NF‐κB/PTGS2 axis and forming a positive feedback loop, which ...
Chanqi Ye, Kefeng Lin, Shuyao Yang, Yan Zhang, Wenli Gao, Jiaqi Chen, Ying Dong, Rui Bai, Yang Tian, Minghao Wang, Zhijun Yuan, Yuxiao Ma, Yuqin He, Ruyin Chen, Wenguang Fu, Qi Jiang, Qiong Li, Jian Ruan   +17 more
wiley   +1 more source

Research on energy consumption and economic growth in Henan Province (China) based on sustainable development

Государственное и муниципальное управление: Учёные записки
Henan Province is a major economic province of China with significant aggregate energy consumption. In the context of studying the problems of factors and elements of sustainable economic development, the author sets the task of researching the ...
Xu Lulu
doaj   +1 more source

MAGED4B is a Poor Prognostic Marker of Stomach Adenocarcinoma and a Potential Therapeutic Target for Stomach Adenocarcinoma Tumorigenesis

International Journal of General Medicine, 2023
Wen-Zhao Luo,1,2 Xian Li,2 Xiu-Xia Wu,2 Yi-Wan Shang,1,3 Dan-Hua Meng,1,3 Yu-Long Chen,1,3 Qin-Sheng Zhang2 1School of Basic Medicine (Zhongjing School), Henan University of Chinese Medicine, Zhengzhou, Henan Province, 45000, People’s Republic of China ...
Luo WZ, Li X, Wu XX, Shang YW, Meng DH, Chen YL, Zhang QS   +6 more
doaj