Results 111 to 120 of about 44,284 (201)

Simeprevir-Based Triple Therapy with Reduced Doses of Pegylated Interferon α-2a Plus Ribavirin for Interferon Ineligible Patients with Genotype 1b Hepatitis C Virus

Gut and Liver, 2017
Background/AimsThe present study aimed to evaluate the safety and efficacy of simeprevir-based triple therapy with reduced doses of pegylated interferon (PEG-IFN) and ribavirin for interferon (IFN) ineligible patients, such as elderly and/or cirrhotic ...
Hideyuki Tamai, Yoshiyuki Ida, Akira Kawashima, Naoki Shingaki, Ryo Shimizu, Kosaku Moribata, Tetsushi Nasu, Takao Maekita, Mikitaka Iguchi, Jun Kato, Taisei Nakao, Masayuki Kitano   +11 more
doaj   +1 more source

Correlative Scanning-Transmission Electron Microscopy Reveals that a Chimeric Flavivirus Is Released as Individual Particles in Secretory Vesicles. [PDF]

, 2014
International audienceThe intracellular morphogenesis of flaviviruses has been well described, but flavivirus release from the host cell remains poorly documented.
Caroline, Sellin, Claude, Lebos, Gaillard, Julien, Jean-Marc, Guillaume, Roingeard, Philippe, Sonia, Georgeault, Uzbekov, Rustem   +6 more
core   +4 more sources

Low-Dose Pegylated Interferon α-2b Plus Ribavirin for Elderly and/or Cirrhotic Patients with Genotype 2 Hepatitis C Virus

Gut and Liver, 2016
Background/AimsThis study aimed to predict sustained viral response (SVR) to low-dose pegylated interferon (PEG-IFN) plus ribavirin of elderly and/or cirrhotic patients with genotype 2 hepatitis C virus (HCV) using viral response within 2 weeks.Methods :
Hideyuki Tamai, Naoki Shingaki, Yoshiyuki Mori, Kosaku Moribata, Akira Kawashima, Yoshimasa Maeda, Toru Niwa, Hisanobu Deguchi, Izumi Inoue, Takao Maekita, Mikitaka Iguchi, Jun Kato, Masao Ichinose   +12 more
doaj   +1 more source

The eukaryotic linear motif resource ELM: 10 years and counting [PDF]

, 2013
The eukaryotic linear motif (ELM http://elm.eu.org) resource is a hub for collecting, classifying and curating information about short linear motifs (SLiMs).
Altenberg, Brigitte, Born, Diana, Budd, Aidan, Chemes, Lucia Beatriz, Davey, Norman E., Diella, Francesca, Dinkel, Holder, Gibson, Toby J, Glavina, Juliana, Grebnev, Gleb, Kruger, Daniel, Kuban, Marta, Michael, Sushama, Seiler, Markus, Speck, Tobias, Strumillo, Marta, Sánchez Miguel, Ignacio Enrique, Uyar, Bora, Van Roey, Kim, Weatheritt, Robert J.   +19 more
core   +6 more sources

Design and nonviral delivery of live attenuated vaccine to prevent chronic hepatitis C virus-like infection

Nature Communications
An effective vaccine for the hepatitis C virus (HCV) remains an unmet medical need. There is no animal model for assessing HCV vaccines; however, rodent hepacivirus (RHV) infection in laboratory rats recapitulates the lifelong chronic hepatotropic ...
Sheetal Trivedi, Piyush Dravid, Tim C. Passchier, Satyapramod Murthy, Kripa Shanker Kasudhan, Narendran Reguraman, Justin Kellar, Rahul Chandra, Cole Cassady, Peter D. Burbelo, Arash Grakoui, Himanshu Sharma, Peter Simmonds, Amit Kapoor   +13 more
doaj   +1 more source

Reactivation of Hepatitis C Virus and Its Clinical Outcomes in Patients Treated with Systemic Chemotherapy or Immunosuppressive Therapy

Gut and Liver, 2017
Background/AimsAccording to the results of several studies, the outcome of hepatitis C virus (HCV) reactivation is not as severe as the outcome of hepatitis B virus reactivation.
Hae Lim Lee, Si Hyun Bae, Bohyun Jang, Seawon Hwang, Hyun Yang, Hee Chul Nam, Pil Soo Sung, Sung Won Lee, Jeong Won Jang, Jong Young Choi, Nam Ik Han, Byung Joo Song, Jong Wook Lee, Seung Kew Yoon   +13 more
doaj   +1 more source

Uji Saring Antigen dan Antibodi Hepatitis C Virus pada Darah Donor [PDF]

, 2015
According to the data from Central Blood Transfusion Unit, the prevalence of hepatitis C virus (HCV) in blood donors in Indonesia and especially Jakarta in 2012 were 0.39% and 0.36% respectively.
Ibrahim, F. (Fera), Rini, P. (Pierlita), Setiawaty, V. (Vivi), Soedarmono, Y. (Yuyun)   +3 more
core  

A twist in the tail : SHAPE mapping of long-range interactions and structural rearrangements of RNA elements involved in HCV replication [PDF]

, 2011
The RNA structure and long-range interactions of the SL9266 cis-acting replication element located within the NS5B coding region of hepatitis C virus (HCV) were determined using selective 2′-hydroxyl acylation analysed by primer extension.
Andrew Tuplin, Bartenschlager, Blight, Blight, Brown, Bukh, Cheng, David J. Evans, Davis, Diviney, Friebe, Friebe, Friebe, Gamarnik, Gesteland, Giegé, Ikeda, Ito, Ito, Jubin, Klinck, Kuiken, Lee, Lindenbach, Liu, Lohmann, Lohmann, Lohmann, Madeleine Struthers, Markham, Matsuda, Matsuda, McMullan, Murayama, Pang, Peter Simmonds, Pietschmann, Romero-López, Romero-López, Schmitt, Simmonds, Song, Tuplin, Tuplin, Tuplin, Wakita, Wang, Wang, Wasley, Wilkinson, Yang, Yi, You, You, Zhao, Zhong, Zuker   +56 more
core   +4 more sources

Prospects for prophylactic hepatitis C vaccines based on virus-like particles. [PDF]

, 2013
International audienceGiven the global prevalence and long-term complications of chronic hepatitis C virus (HCV) infection, HCV constitutes one of the greatest challenges to human health of this decade.
Beaumont, Elodie, Roingeard, Philippe
core   +3 more sources

A library of infectious hepatitis C viruses with engineered mutations in the E2 gene reveals growth-adaptive mutations that modulate interactions with scavenger receptor class B type I [PDF]

, 2016
While natural hepatitis C virus (HCV) infection results in highly diverse quasispecies of related viruses over time, mutations accumulate more slowly in tissue culture, in part because of the inefficiency of replication in cells.
Chen, Kevin, Diamond, Michael S, Evans, Matthew J, Fremont, Daved H, Luca, Vincent C, Schwarz, Megan C, Wang, David, White, James P, Zuiani, Adam   +8 more
core   +2 more sources