Results 111 to 120 of about 16,038 (235)

The modeled structure of the RNA dependent RNA polymerase of GBV-C Virus suggests a role for motif E in Flaviviridae RNA polymerases [PDF]

, 2005
BACKGROUND: The Flaviviridae virus family includes major human and animal pathogens. The RNA dependent RNA polymerase (RdRp) plays a central role in the replication process, and thus is a validated target for antiviral drugs.
Bussetta, Cécile, Canard, Bruno, Dutartre, Hélène, Ferron, François   +3 more
core   +4 more sources

Electron microscopy: The key to resolve RNA viruses replication organelles

Molecular Microbiology, Volume 121, Issue 4, Page 679-687, April 2024.
Positive‐strand RNA viruses replicate their genome within specialized virus‐induced intracellular compartments called “replication organelles”. Technological advances in electron microscopy allowed detailed characterization of such structures unveiling their three‐dimensional architecture and molecular composition.
Debora Stelitano, Mirko Cortese
wiley   +1 more source

Simeprevir-Based Triple Therapy with Reduced Doses of Pegylated Interferon α-2a Plus Ribavirin for Interferon Ineligible Patients with Genotype 1b Hepatitis C Virus

Gut and Liver, 2017
Background/AimsThe present study aimed to evaluate the safety and efficacy of simeprevir-based triple therapy with reduced doses of pegylated interferon (PEG-IFN) and ribavirin for interferon (IFN) ineligible patients, such as elderly and/or cirrhotic ...
Hideyuki Tamai, Yoshiyuki Ida, Akira Kawashima, Naoki Shingaki, Ryo Shimizu, Kosaku Moribata, Tetsushi Nasu, Takao Maekita, Mikitaka Iguchi, Jun Kato, Taisei Nakao, Masayuki Kitano   +11 more
doaj   +1 more source

Treatment of anicteric acute hepatitis C with peginterferon alpha-2a plus ribavirin [PDF]

Vojnosanitetski Pregled, 2005
Background. Hepatitis C virus (HCV) infection is the most frequent cause of chronic hepatitis, cirrhosis, and hepatocellular carcinoma in the world. Acute hepatitis C is the most commonly asymptomatic liver disease with the development of chronic HCV ...
Delić Dragan, Nešić Zorica I., Prostran Milica Š., Simonović Jasmina, Švirtlih Neda   +4 more
doaj   +1 more source

The Genetic and Molecular Studies of Hepatitis C Virus: A Review [PDF]

, 2011
The role of Hepatitis viruses, particularly Hepatitis c virus (HCV) as human pathogen and their transmission have been of interest over the years. The virus is a small (55-65nm in size), included in Group IV, enveloped, positive sense, single stranded ...
Akogwu, S, Aliyu, AM, Aminu, BM, Rogo, LD, Umar, UZ   +4 more
core   +2 more sources

First identification and phylogenetic analysis of equine hepacivirus in Korea

Infection, Genetics and Evolution, 2017
Non-primate hepacivirus (NPHV) corresponds a group of isolates recently characterized in horses and dogs that present similar genomic organization and are closely related to hepatitis C virus. Since canine hapacivirus, NPHV identified in dogs, was first discovered in dogs in the United States, equine hepacivirus (EqHV, NPHV identified in horses) has ...
Hyuk Moo Kwon, Hyun-Woo Moon, Haan Woo Sung, Ho-Seong Kim   +3 more
openaire   +3 more sources

Low-Dose Pegylated Interferon α-2b Plus Ribavirin for Elderly and/or Cirrhotic Patients with Genotype 2 Hepatitis C Virus

Gut and Liver, 2016
Background/AimsThis study aimed to predict sustained viral response (SVR) to low-dose pegylated interferon (PEG-IFN) plus ribavirin of elderly and/or cirrhotic patients with genotype 2 hepatitis C virus (HCV) using viral response within 2 weeks.Methods :
Hideyuki Tamai, Naoki Shingaki, Yoshiyuki Mori, Kosaku Moribata, Akira Kawashima, Yoshimasa Maeda, Toru Niwa, Hisanobu Deguchi, Izumi Inoue, Takao Maekita, Mikitaka Iguchi, Jun Kato, Masao Ichinose   +12 more
doaj   +1 more source

Delayed by Design: Role of Suboptimal Signal Peptidase Processing of Viral Structural Protein Precursors in Flaviviridae Virus Assembly

Viruses, 2020
The Flaviviridae virus family is classified into four different genera, including flavivirus, hepacivirus, pegivirus, and pestivirus, which cause significant morbidity and mortality in humans and other mammals, including ruminants and pigs.
Nabeel Alzahrani, Ming-Jhan Wu, Saravanabalaji Shanmugam, MinKyung Yi   +3 more
doaj   +1 more source

Trends in the burden of most common obesity‐related cancers in 16 Southern Africa development community countries, 1990–2019. Findings from the global burden of disease study

Obesity Science &Practice, Volume 10, Issue 1, February 2024.
Obesity‐related cancers in the 16 SADC countries is quite prominent but the time trends in mortality are unknown. We analyzed data obtained from the 2019 Global Burden of Diseases Study. For males in 2019, mortality rates for leukaemia, oesophageal, colon/rectum cancer were the most prominent, whereas for females, breast cancer, leukaemia, oesophageal ...
Philimon Gona, Clara Gona, Suha Ballout, Chabila Mapoma, Sowmya Rao, Ali Mokdad, (GBD 2019 SADC BMI)   +6 more
wiley   +1 more source

Metformin and statins reduce hepatocellular carcinoma risk in chronic hepatitis C patients with failed antiviral therapy [PDF]

Clinical and Molecular Hepatology
Background/Aims Chronic hepatitis C (CHC) patients who failed antiviral therapy are at increased risk for hepatocellular carcinoma (HCC). This study assessed the potential role of metformin and statins, medications for diabetes mellitus (DM) and ...
Pei-Chien Tsai, Chung-Feng Huang, Ming-Lun Yeh, Meng-Hsuan Hsieh, Hsing-Tao Kuo, Chao-Hung Hung, Kuo-Chih Tseng, Hsueh-Chou Lai, Cheng-Yuan Peng, Jing-Houng Wang, Jyh-Jou Chen, Pei-Lun Lee, Rong-Nan Chien, Chi-Chieh Yang, Gin-Ho Lo, Jia-Horng Kao, Chun-Jen Liu, Chen-Hua Liu, Sheng-Lei Yan, Chun-Yen Lin, Wei-Wen Su, Cheng-Hsin Chu, Chih-Jen Chen, Shui-Yi Tung, Chi‐Ming Tai, Chih-Wen Lin, Ching-Chu Lo, Pin-Nan Cheng, Yen-Cheng Chiu, Chia-Chi Wang, Jin-Shiung Cheng, Wei-Lun Tsai, Han-Chieh Lin, Yi-Hsiang Huang, Chi-Yi Chen, Jee-Fu Huang, Chia-Yen Dai, Wan-Long Chung, Ming-Jong Bair, Ming-Lung Yu, T-COACH Study Group   +40 more
doaj   +1 more source