Results 111 to 120 of about 44,632 (248)

Real-World Single-Center Experience with Sofosbuvir-Based Regimens for the Treatment of Chronic Hepatitis C Genotype 1 Patients

Gut and Liver, 2017
Background/AimsThe approval of sofosbuvir (SOF), a direct-acting antiviral, has revolutionized the treatment of chronic hepatitis C virus (HCV).Methods : We assessed the sustained virological response (SVR) of SOF-based regimens in a real-world single ...
Hyun Phil Shin, Blaire Burman, Richard A. Kozarek, Amy Zeigler, Chia Wang, Houghton Lee, Troy Zehr, Alicia M. Edwards, Asma Siddique   +8 more
doaj   +1 more source

The KNIME Based Classification Models for Yellow Fever Virus Inhibition [PDF]

, 2015
The Naïve Bayes method as implemented in KNIME platform for classification of YFV inhibition. The best classification model is able to correctly discriminate >90% of inhibitors and non-inhibitors.
Moorthy, NHS, Poongavanam, Vasanthanathan   +1 more
core   +2 more sources

A comprehensive overview on the crosstalk between microRNAs and viral pathogenesis and infection

Medicinal Research Reviews, Volume 45, Issue 2, Page 349-425, March 2025.
Abstract Infections caused by viruses as the smallest infectious agents, pose a major threat to global public health. Viral infections utilize different host mechanisms to facilitate their own propagation and pathogenesis. MicroRNAs (miRNAs), as small noncoding RNA molecules, play important regulatory roles in different diseases, including viral ...
Seyedeh Zahra Bahojb Mahdavi, Asiyeh Jebelli, Parisa Shiri Aghbash, Behzad Baradaran, Mohammad Amini, Fatemeh Oroojalian, Nasser Pouladi, Hossein Bannazadeh Baghi, Miguel de la Guardia, Amir Ali Mokhtarzadeh   +9 more
wiley   +1 more source

Prevalence and Incidence of Depression during Interferon-Based Antiviral Therapy in Chronic Hepatitis C Patients in the Republic of Korea

Gut and Liver, 2017
Background/AimsThe association between depression and chronic hepatitis C virus (HCV) infection or pegylated interferon α and ribavirin therapy (PR therapy) has not been extensively studied in Korea.
Joo Yeong Baeg, In Hee Kim, Seung Young Seo, Young Seok Kim, Eun Uk Jung, Junhyeon Cho, Jung Wha Chung, Eun Sun Jang, Jin Wook Kim, Sook-Hyang Jeong   +9 more
doaj   +1 more source

Hepatitis C Virus Saint Petersburg Variant Detection With Machine Learning Methods

Journal of Medical Virology, Volume 97, Issue 2, February 2025.
ABSTRACT Hepatitis C virus infection is a significant global health concern, affecting millions worldwide. Although direct‐acting antivirals achieve over 90% success rate, treatment failures still occur, particularly when pan‐genotypic DAAs are unavailable, and drugs need to be chosen based on the present HCV genotype.
Nurhan Arslan, Bernhard Reuter, Joachim Buech, Thomas Lengauer, Martin Obermeier, Rolf Kaiser, Nico Pfeifer   +6 more
wiley   +1 more source

First identification and phylogenetic analysis of equine hepacivirus in Korea

Infection, Genetics and Evolution, 2017
Non-primate hepacivirus (NPHV) corresponds a group of isolates recently characterized in horses and dogs that present similar genomic organization and are closely related to hepatitis C virus. Since canine hapacivirus, NPHV identified in dogs, was first discovered in dogs in the United States, equine hepacivirus (EqHV, NPHV identified in horses) has ...
Ho-Seong, Kim, Hyun-Woo, Moon, Haan Woo, Sung, Hyuk Moo, Kwon   +3 more
openaire   +2 more sources

Characterization of nonprimate hepacivirus and construction of a functional molecular clone [PDF]

Proceedings of the National Academy of Sciences, 2015
Significance The origin of hepatitis C virus (HCV) has long remained a mystery. Unexpectedly, a plethora of HCV-related hepaciviruses was recently discovered in horses, monkeys, rodents, and bats. These discoveries are of particular interest and may aid in understanding HCV evolution, molecular biology, and natural history.
Troels K. H. Scheel, Amit Kapoor, Eiko Nishiuchi, Kenny V. Brock, Yingpu Yu, Linda Andrus, Meigang Gu, Randall W. Renshaw, Edward J. Dubovi, Sean P. McDonough, Gerlinde R. Van de Walle, W. Ian Lipkin, Thomas J. Divers, Bud C. Tennant, Charles M. Rice   +14 more
openaire   +3 more sources

Final Report of Unmet Needs of Interferon-Based Therapy for Chronic Hepatitis C in Korea: Basis for Moving into the Direct-Acting Antiviral Era

Gut and Liver, 2017
Background/AimsTo evaluate the era of direct acting antivirals (DAAs), we must understand the treatment patterns and outcomes of interferon-based therapy for hepatitis C virus (HCV) infection.
Eun Sun Jang, Young Seok Kim, Kyung-Ah Kim, Youn Jae Lee, Woo Jin Chung, In Hee Kim, Byung Seok Lee, Sook-Hyang Jeong   +7 more
doaj   +1 more source

Il Trattamento Della Recidiva di Epatite C dopo Trapianto di Fegato con Sofosbuvir e Ribavirina [PDF]

, 2016
Introduzione: Sono ancora poco conosciute le variabili cliniche in grado di predire l’insuccesso della terapia antivirale di combinazione con sofosbuvir (SOF) e ribavirina (RIBA) nei pazienti sottoposti a trapianto di fegato (LT) e affetti da recidiva di
RETI, SILVIA LAURA
core  

Comprehensive Enteroviral Serology Links Infection and Anti‐Melanoma Differentiation‐Associated Protein 5 Dermatomyositis

ACR Open Rheumatology, Volume 7, Issue 1, January 2025.
Objective Idiopathic inflammatory myopathies (IIMs) are a group of heterogeneous, systemic autoimmune diseases characterized by specific clinical features and, frequently, skeletal muscle inflammation. Specific subtypes of IIMs can be characterized by myositis‐specific autoantibodies and are associated with distinct clinical phenotypes.
Sahana Jayaraman, Eleni Tiniakou, William R. Morgenlander, Miso Na, Lisa Christopher‐Stine, H. Benjamin Larman   +5 more
wiley   +1 more source