Results 141 to 150 of about 43,714 (247)
Gut and Liver, 2017 Background/AimsAccording to the results of several studies, the outcome of hepatitis C virus (HCV) reactivation is not as severe as the outcome of hepatitis B virus reactivation.
Hae Lim Lee +13 more
doaj +1 more source
Metabolic Dysregulation in Hepacivirus Infection of Common Marmosets (Callithrix jacchus)
PLOS ONE, 2017 Chronic hepatitis C has been associated with metabolic syndrome that includes insulin resistance, hepatic steatosis and obesity. These metabolic aberrations are risk factors for disease severity and treatment outcome in infected patients. Experimental infection of marmosets with GBV-B serves as a tangible, small animal model for human HCV infection ...
Manickam, Cordelia +4 more
openaire +6 more sources
Nature CommunicationsAn effective vaccine for the hepatitis C virus (HCV) remains an unmet medical need. There is no animal model for assessing HCV vaccines; however, rodent hepacivirus (RHV) infection in laboratory rats recapitulates the lifelong chronic hepatotropic ...
Sheetal Trivedi +13 more
doaj +1 more source
Modeling HCV disease in animals: virology, immunology and pathogenesis of HCV and GBV-B infections [PDF]
, 2014 Hepatitis C virus (HCV) infection has become a global public health burden costing billions of dollars in health care annually. Even with rapidly advancing scientific technologies this disease still poses a significant threat due to a lack of vaccines ...
Manickam, Cordelia, Reeves, R. Keith
core +2 more sources
Evolving drug therapies for chronic hepatitis C: Immunomodulation and beyond [PDF]
, 2011 Chronic hepatitis C infection is a major health problem and a leading cause of chronic liver disease. The hepatitis C virus was discovered in 1989 (1, 2).
Bergmann, J.F. (Jilling)
core
Prospects for prophylactic hepatitis C vaccines based on virus-like particles. [PDF]
, 2013 International audienceGiven the global prevalence and long-term complications of chronic hepatitis C virus (HCV) infection, HCV constitutes one of the greatest challenges to human health of this decade.
Beaumont, Elodie, Roingeard, Philippe
core +3 more sources
Seroepidemiology of non-primate hepacivirus (NPHV) in Japanese native horses
Journal of Veterinary Medical Science, 2018 Non-primate hepacivirus (NPHV) is recently identified as a closely related homologue of hepatitis C virus. The previous studies showed a high prevalence of NPHV infection among Japanese domestic horses originated from abroad. The historical distribution of NPHV among horses in Japan, therefore, is still unknown. In this study, seroepidemiological study
Kazuhiro Hirayama +5 more
openaire +3 more sources
Inhibition of RNA helicases of ssRNA+ virus belonging to Flaviviridae, Coronaviridae and Picornaviridae families [PDF]
, 2011 Many viral pathogens encode the motor proteins named RNA helicases which display various functions in genome replication. General strategies to design specific and selective drugs targeting helicase for the treatment of viral infections could act via one
Briguglio, Irene +3 more
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Uji Saring Antigen dan Antibodi Hepatitis C Virus pada Darah Donor [PDF]
, 2015 According to the data from Central Blood Transfusion Unit, the prevalence of hepatitis C virus (HCV) in blood donors in Indonesia and especially Jakarta in 2012 were 0.39% and 0.36% respectively.
Ibrahim, F. (Fera) +3 more
core
Space constrained homology modelling: The paradigm of the RNA-dependent RNA polymerase of dengue (Type II) virus [PDF]
, 2013 Protein structure is more conserved than sequence in nature. In this direction we developed a novel methodology that significantly improves conventional homology modelling when sequence identity is low, by taking into consideration 3D structural features
Kontopoulos, DG +2 more
core +2 more sources