Results 131 to 140 of about 724,197 (388)

Spatially restricted patterning cues provided by heparin-binding VEGF-A control blood vessel branching morphogenesis.

Genes & Development, 2002
Branching morphogenesis in the mammalian lung and Drosophila trachea relies on the precise localization of secreted modulators of epithelial growth to select branch sites and direct branch elongation, but the intercellular signals that control blood ...
C. Ruhrberg, H. Gerhardt, M. Golding, R. Watson, S. Ioannidou, H. Fujisawa, C. Betsholtz, D. Shima   +7 more
semanticscholar   +1 more source

Cancer Cell‐Intrinsic Cholesterol Induces Lipid‐Associated Macrophage Differentiation via SP1 Palmitoylation to Promote Prostate Cancer Progression

Advanced Science, EarlyView.
Cancer cell‐intrinsic cholesterol promotes the S‐palmitoylation of SP1, increasing its nuclear translocation and driving the transcription and secretion of MDK, which in turn facilitates the differentiation of macrophages into a lipid‐associated phenotype.
Shirong Peng, Weilong Lin, Zean Li, Ruilin Zhuang, Shengmeng Peng, Bingheng Li, Bingliang Chen, Yong Luo, Yuan Ou, Wei Zhuang, Tao Du, Kaiwen Li, Hai Huang   +12 more
wiley   +1 more source

Making heparin safe [PDF]

, 2016
JEAN-FRANÇOIS TREMBLAY
openalex   +1 more source

TREM2 Drives Neutrophil Extracellular Traps‐Induced Dendritic Cell Maturation and Contributes to Lupus Progression

Advanced Science, EarlyView.
TREM2 recognizes NETs‐derived MPO to promote DC maturation and antigen presentation, thereby exacerbating the autoimmune response in SLE. Mechanistically, TREM2 activation triggers the DAP12/SYK/ERK cascade and enhances NETs internalization by DCs, which in turn activates the cGAS/STING signaling pathway.
Jingxian Shu, Jiabi Liang, Linda Zeng, Shuping Zhong, Xueling Fang, Yating Xu, Yongjian Wu, Xi Huang   +7 more
wiley   +1 more source

Off-pump coronary artery bypass grafting using continuous heparin infusion

Indian Heart Journal, 2016
Objectives: Levels of anticoagulation during off-pump coronary artery bypass grafting (OPCAB) remain controversial. Prolonged activated clotting time (ACT) during OPCAB increases blood loss during surgery and can also cause paradoxical increase in ...
Kamales Kumar Saha, Dinesh Kumar Sangwan, Pravin K. Shroff, Mandar Manohar Deval, Kakalee K. Saha, Rinu V. Jacob, Ratnaprobha Adsul, Lukash Jagdale   +7 more
doaj   +1 more source

WHEN TWO RARE CONDITIONS COLLIDE: HEPARIN-INDUCED THROMBOCYTOPENIA COMPLICATED BY "RIGHT-SIDED" MAY-THURNER SYNDROME [PDF]

, 2023
WILLIAM PEREZ MORALES, GUILLERMO LOYOLA, J. R. Torres Alfonso, G. Aguilera, SEAN BAKSH, FUHBE MFONE, MOHAMED IBRAHIM AHMED, MICHAEL MINICHIELLO, JOSE SANCHEZ   +8 more
openalex   +1 more source

Nurr1 Orchestrates Claustrum Development and Functionality

Advanced Science, EarlyView.
Nurr1 (Nr4a2) is the master transcription factor to control claustrum morphogenesis and cell fate decision postmitotically by inhibiting intracellular G‐protein signaling. Nurr1 deficiency alters the transcriptomic profiles of subcortical claustral neurons into neocortical insular neurons, resulting in defected claustrum development, impaired axonal ...
Kuo Yan, Andrew G. Newman, Pauline Lange, Susanne Müller, Marco Foddis, Stefan Paul Koch, Philipp Böhm‐Sturm, Maron Mantwill, Carsten Finke, Penghui Deng, Melissa Long, Dietmar Schmitz, Victor Tarabykin   +12 more
wiley   +1 more source

Bleeding after hip arthroplasty not increased by heparin plus dihydroergotamine [PDF]

, 1987
S. Winter Christensen, Torben Jørgensen, A Bjerg-Nielsen, Per Hölmich, Benn Duus   +4 more
openalex   +1 more source

Depletion of Sorcs3 Activates Totipotency in Mouse Embryonic Stem Cells by Modulating Key Signaling Pathways

Advanced Science, EarlyView.
In this article, Shuai and colleagues found that depletion of Sorcs3 could activate totipotency in mESCs, promising bidirectional differentiation potential to embryonic and extraembryonic lineages. The underlying mechanism might be activation of Tfap2c and repression of TGF‐β, PI3K‐AKT, and lysosome pathways.
Wenhao Zhang, Xinyu Mao, Yu He, Qingshen Jia, Yiding Zhao, Xiaomeng Dai, Xiaoyan Li, Shengyi Sun, Xiaoyan Sheng, Dan Ding, Yuan Shi, Qian Gao, Ling Shuai   +12 more
wiley   +1 more source

The variable use of heparin through intravenous bolus and flush fluid systems during endovascular stroke treatment, a world-wide survey

CVIR Endovascular
Background The total amount of heparin administered through flush fluids in stroke patients is not considered in recent trials, possibly influencing main results. We investigated the use of heparin among treating physicians worldwide.
Senta Frol, Faysal Benali, Aymeric Rouchaud, Robrecht R. M. M. Knapen, Wim H. van Zwam, Research Committee of the European Society of Minimally Invasive Neurological Therapy (ESMINT)   +5 more
doaj   +1 more source