Results 131 to 140 of about 522,479 (352)

P21‐Activated Kinase 2 as a Novel Target for Ventricular Tachyarrhythmias Associated with Cardiac Adrenergic Stress and Hypertrophy

Advanced Science, EarlyView.
Ca2+/calmodulin‐dependent kinase II (CaMKII) activation is likely driven by oxidative stress, particularly excessive reactive oxygen species (ROS) production. This study identifies P21‐activated kinase 2 (Pak2) as a novel regulator of ROS‐induced CaMKII activation and abnormal Ca2⁺ dynamics in acute adrenergic and chronic pressure‐overload stressed ...
Tao Li, Ting Liu, Yan Wang, Yangpeng Li, Leiying Liu, James Bae, Yu He, Xian Luo, Zhu Liu, Tangting Chen, Xianhong Ou, Dan Zhang, Huan Lan, Juyi Wan, Yan Wei, Fang Zhao, Xin Wang, Tao Li, Christopher L.‐H. Huang, Chunxiang Zhang, Ming Lei, Xiaoqiu Tan   +21 more
wiley   +1 more source

Interleukin 6/gp130 axis promotes neural invasion in pancreatic cancer

Cancer Medicine, Volume 11, Issue 24, Page 5001-5012, December 2022., 2022
Nerve invasion (N‐inv) is an important prognostic factor in pancreatic ductal adenocarcinoma (PDAC). To elucidate circulating stimulators for nerve invasion, the authors evaluated the stimulant activity and the inhibitory effects of IL‐6/gp130 axis. Biological activity of IL‐6/gp130 axis promoted nerve invasion in murine model and was upregulated in ...
Hidetaka Suzuki, Shuichi Mitsunaga, Masafumi Ikeda, Takao Aoyama, Kazumi Yoshizawa, Masayuki Yamaguchi, Masami Suzuki, Minoru Narita, Toshikatsu Kawasaki, Atsushi Ochiai   +9 more
wiley   +1 more source

Ligand Rebinding: Self-consistent Mean-field Theory and Numerical Simulations Applied to SPR Studies [PDF]

Eur. Biophys. J. 34 (2005) 943, 2004
Rebinding of dissociated ligands from cell surface proteins can confound quantitative measurements of dissociation rates important for characterizing the affinity of binding interactions. This can be true also for in vitro techniques such as surface plasmon resonance (SPR).
arxiv  

Preparation of Heparin and Its Use in the First Clinical Cases [PDF]

, 1959
C. H. Best
openalex   +1 more source

Depletion of Hepatic SREBP2 Protects Against Hypercholesterolemia and Atherosclerosis through the ANGPTL3‐LPL Axis

Advanced Science, EarlyView.
This study reveals a novel crosstalk between hepatic SREBP2‐mediated cholesterol biosynthesis pathway and peripheral lipoprotein lipase‐mediated lipolysis pathway in the regulation of systemic lipid metabolism. Notably, the lipid‐lowering effects of SREBP2 inhibition are independent of a functional LDL receptor, highlighting the potential of acute ...
Yifan Wang, Jia You Sarafina Choe, Yu Shi, Thi Tun Thi, Xiaoyun Cao, Yang Hu, Kai Yan Cheng, Hui Li, Yang Ji, Yan Liu, Matthew Ackers‐Johnson, Roger S.Y. Foo, Yujia Shen, Haojie Yu   +13 more
wiley   +1 more source

The Comparative Study of Efficiency of Intravenous Heparin and Oral Aspirin on 48 Hours Beginning Primary Medication in Ischemic Stroke Patients

Journal of Rehabilitation, 2005
Objective: This study was done for comparing efficiency of Intravenous Heparin and Oral Aspirin among patients who had cerebral thrombi embolitic vascular accidents.
Ali Akbar Rezaei, Shahir Mazaheri, Saeed Bashirian, Nima Rezaei   +3 more
doaj  

THE EFFECT OF INTRAVENOUS INFUSION OF THROMBOPLASTIN ON “HEPARIN TOLERANCE” 1 [PDF]

, 1951
Robert C. Hartmann, C. Lockard Conley, Julius R. Krevans, Edwin L. Poole, Nancy M. Dick   +4 more
openalex   +1 more source

3D‐Printed Biomimetic Vascular Scaffold Crosslinked with Heparan Sulfate for Sustained Release of PDGFB‐LG4 Fusion Protein Promotes Bone Regeneration

Advanced Science, EarlyView.
Fusion protein PDGFB‐LG4 exhibits superior osteoinductive and angiogenic activity compared to PDGFB. The PCLHS‐PDGFB‐LG4 scaffold, featuring perfusable and permeable vascular‐like networks, promotes angiogenesis and osteogenesis through the sustained release of PDGFB‐LG4, thereby accelerating the bone defect repair process.
Jiahua Duan, Gaofei Qian, Huikang Zhang, Feifan Wang, Qiang Tian, Dong Lei, Jianning Zhao   +6 more
wiley   +1 more source

Evaluation of factors associated with selection for coronary angiography and in‐hospital mortality among patients presenting with out‐of‐hospital cardiac arrest without ST‐segment elevation

Catheterization and Cardiovascular Interventions, Volume 100, Issue 7, Page 1159-1170, December 1, 2022., 2022
Abstract Background Clinical factors favouring coronary angiography (CA) selection and variables associated with in‐hospital mortality among patients presenting with out‐of‐hospital cardiac arrest (OHCA) without ST‐segment elevation (STE) remain unclear.
Wayne C. Zheng, Samer Noaman, Riley J. Batchelor, Laura Hanson, Jason E. Bloom, Omar Al‐Mukhtar, Kawa Haji, Nicholas D'Elia, Felicia C. S. Ho, David Kaye, James Shaw, Yang Yang, Craig French, Dion Stub, Nicholas Cox, William Chan   +15 more
wiley   +1 more source

Identification of heparin interaction sites on thrombin-activatable fibrinolysis inhibitor that modulate plasmin-mediated activation, thermal stability, and antifibrinolytic potential

Research and Practice in Thrombosis and Haemostasis
Background: Thrombin-activatable fibrinolysis inhibitor (TAFI) is a plasma zymogen that provides a molecular link between coagulation and fibrinolysis. Studies have shown that the presence of glycosaminoglycans accelerates TAFI activation by plasmin and ...
Tanya T. Marar, Michael B. Boffa
doaj