Results 161 to 170 of about 507,262 (350)

Exploring heparin’s protective mechanism against AGEs induced endothelial injury

iScience
Summary: Advanced glycation end products (AGEs) in diabetes can cause endothelial damage. Heparin, widely known as a recognized anticoagulant, is also a multifunctional therapeutic drug.
Junfeng Shi, Yudong Guan, Hongwei Song, Liang Zhu, Jingjing Li, Qinying Li, Ningning Hou, Fang Han, Meng Wang, Kexin Zhang, Ming Shan, Xiaodong Sun, Hongyan Qiu   +12 more
doaj   +1 more source

Low-molecular-weight heparin versus a coumarin for the prevention of recurrent venous thromboembolism in patients with cancer.

New England Journal of Medicine, 2003
Agnes Y. Y. Lee, M. Levine, R. Baker, C. Bowden, A. Kakkar, M. Prins, F. Rickles, J. Julian, S. Haley, M. Kovacs, M. Gent   +10 more
semanticscholar   +1 more source

A Novel NR3C1 Frameshift Variant Associated With Familial Glucocorticoid Resistance Syndrome: An Integrated Analysis of Steroid Profiling and Structural Modeling

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Glucocorticoid resistance syndrome (GRS) is a rare hereditary disorder caused by pathogenic variants in NR3C1, characterized by marked phenotypic heterogeneity and frequent misdiagnosis as primary aldosteronism or subclinical Cushing's syndrome.
Sufang Yun, Zhifeng Zhu, Fengye Zhou, Ying Liu, Chunfang Liang, Haitao Ju, Lin Lu, Zhaoli Yan   +7 more
wiley   +1 more source

Regional gas exchange evaluation during ex vivo lung perfusion in a swine model of localized lung dysfunction

Animal Models and Experimental Medicine, EarlyView.
Abstract Background Ex vivo lung perfusion (EVLP) allows the evaluation of lungs that do not meet standard transplantation criteria. Current procedures do not permit the identification of regional functional deficits. We investigated the feasibility of assessing lobar gas exchange during EVLP in a swine model.
Giulia Maria Ruggeri, Elena Chiodaroli, Matteo Montoli, Sara Pieropan, Alessandro Santini, Gianluca Lopez, Michele Battistin, Luigi Vivona, Sebastiano Maria Colombo, Jacopo Fumagalli, Eleonora Carlesso, Stefano Ferrero, Lorenzo Rosso, Stefano Gatti, Antonio Maria Pesenti, Giacomo Grasselli, Alberto Zanella   +16 more
wiley   +1 more source

Heparin-binding protein and endothelin-1 in acute inflammation and trauma [PDF]

Inflammation in sepsis and trauma is a clinical challenge and despite advances in supportive care, morbidity and mortality are high. The mechanisms behind this inflammation are extremely complicated, involving numerous molecular pathways.
Halla Halldorsdottir (18667564)
core   +1 more source

The Comparative Study of Efficiency of Intravenous Heparin and Oral Aspirin on 48 Hours Beginning Primary Medication in Ischemic Stroke Patients

Journal of Rehabilitation, 2005
Objective: This study was done for comparing efficiency of Intravenous Heparin and Oral Aspirin among patients who had cerebral thrombi embolitic vascular accidents.
Ali Akbar Rezaei, Shahir Mazaheri, Saeed Bashirian, Nima Rezaei   +3 more
doaj  

A novel rat model of pulmonary artery embolism and the application value of lung ultrasound B‐lines in early‐stage pulmonary embolism

Animal Models and Experimental Medicine, EarlyView.
We report a novel embolus‐induced PE rat model prepared via the inferior vena cava under ultrasound guidance. The embolus employed featured a tubular plastic casing filled with thrombus. By minimizing the contact surface between plasmin and thrombus, it effectively restrains the elevated plasmin activity in rats.
Huide Ma, Shuangrui Wang, Honghui Li, Yaxing Zhang, Yuman Gao, Jie Zhou, Xia Xu, Rong Wu   +7 more
wiley   +1 more source

Tensile Stimulation in Biorelevant Culture Conditions Enhances MSC and TPSC Tenogenesis on Aligned Electrospun Scaffolds

Advanced NanoBiomed Research, EarlyView.
Biomimetic electrospun scaffold incorporating GDF‐7‐loaded mesoporous silica nanoparticles, combined with mechanical stimulation and physiological oxygen tension, guides tenogenic differentiation of mesenchymal stromal cell and tendon progenitor stem cell. This integrated approach enhances cell proliferation, matrix deposition, and tendon‐specific gene
Vera Citro, Aldo R. Boccaccini, Nicholas R. Forsyth, Tina P. Dale   +3 more
wiley   +1 more source

Biomedical applications of engineered heparin-based materials

Bioactive Materials
Heparin is a negatively charged polysaccharide with various chain lengths and a hydrophilic backbone. Due to its fascinating chemical and physical properties, nontoxicity, biocompatibility, and biodegradability, heparin has been extensively used in ...
Ehsan Nazarzadeh Zare, Danial Khorsandi, Atefeh Zarepour, Hulya Yilmaz, Tarun Agarwal, Sara Hooshmand, Reza Mohammadinejad, Fatma Ozdemir, Onur Sahin, Sevin Adiguzel, Haroon Khan, Ali Zarrabi, Esmaeel Sharifi, Arun Kumar, Ebrahim Mostafavi, Negar Hosseinzadeh Kouchehbaghi, Virgilio Mattoli, Feng Zhang, Vadim Jucaud, Alireza Hassani Najafabadi, Ali Khademhosseini   +20 more
doaj   +1 more source

Heparin-induced thrombocytopenia in patients treated with low-molecular-weight heparin or unfractionated heparin.

New England Journal of Medicine, 1995
T. Warkentin, Mark Levine, J. Hirsh, P. Horsewood, R. Roberts, M. Gent, J. Kelton   +6 more
semanticscholar   +1 more source