Results 191 to 200 of about 724,197 (388)

Targeted Degradation of eEF2K by a Structure‐Guided PROTAC Strategy for the Treatment of Triple‐Negative Breast Cancer

open access: yesAdvanced Science, EarlyView.
This study developed an eEF2K‐targeting PROTAC, A6, that efficiently degrades eEF2K in TNBC cells, inhibiting tumor growth in vitro and in vivo. To enhance tumor‐specific delivery, we engineered A6@ZIF‐8, a pH‐sensitive nanocarrier, which improved drug accumulation at tumor sites, offering a promising therapeutic strategy for TNBC through targeted ...
Shijun Cao   +10 more
wiley   +1 more source

Low-Molecular-Weight Heparin Versus Aspirin for Acute Ischemic Stroke With Large Artery Occlusive Disease [PDF]

open access: bronze, 2011
Qiao Shu Wang   +7 more
openalex   +1 more source

Antibody‐Empowered Nanomedicine for Precise Biomedical Applications

open access: yesAdvanced Science, EarlyView.
This review explores strategies for functionalizing nanoparticles with antibodies to construct antibody‐empowered nanomedicine. It discusses the classification of these nanomedicines based on antibody structure, with a specific focus on their biomedical applications in diagnostics, bioimaging, and therapeutics for various diseases.
Chen Chen   +7 more
wiley   +1 more source

Heparin-free after 3000 IU heparin loaded in veno-venous ECMO supported acute respiratory failure patients with hemorrhage risk: a novel anti-coagulation strategy [PDF]

open access: gold, 2022
Yangchao Zhao   +12 more
openalex   +1 more source

Engineered Bacteria‐Vesicle Delivered Lactate Reprogramming Boosts Tumor Radiosensitivity

open access: yesAdvanced Science, EarlyView.
We engineered a bacterial‐vesicular dual‐delivery platform that targets LOx to colorectal tumors, enabling lactate clearance, immune microenvironment remodeling, and microbiota modulation. This microbe–metabolism synergistic strategy effectively sensitizes colorectal cancer to radiotherapy, offering a promising approach to overcome radioresistance ...
Fei Peng   +11 more
wiley   +1 more source

Device Performance of Emerging Photovoltaic Materials (Version 6)

open access: yesAdvanced Energy Materials, EarlyView.
Efficiency of single junction perovskite (circles), organic (hexagons), dye sensitized (pentagons), kesterite (diamonds), Sb2Se3 (right triangle), and AgBiS2 (left triangles) solar cells at emerging‐pv.org over the last decade. ABSTRACT This 6th annual Emerging PV Report surveys peer‐reviewed advances since August 2024 across perovskite, organic ...
Osbel Almora   +29 more
wiley   +1 more source

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