Results 201 to 210 of about 575,699 (254)
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Mode of action of heparin lyase on heparin
Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1982Heparinase (heparin lyase, EC 4.2.2.7) prepared from Flavobacterium heparinum was used to digest heparin. The products of digestion were examined with a viscosometric assay at various stages of the reaction to measure their average molecular weight.
Charles L. Cooney +4 more
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Metachromatic activity of heparin and heparin fragments
Analytical Biochemistry, 1984Heparin of an average molecular weight of 13,000 was fractionated on the basis of size into five fractions of different weight-average molecular weight ranging from 8500 to 20,000. The heparin was also degraded using microbial heparinase resulting in products ranging from a disaccharide of molecular weight 500 to an oligosaccharide of molecular weight ...
Robert J. Linhardt +4 more
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Heparin and low-molecular-weight heparin
Thrombosis and Haemostasis, 2008SummaryHeparin is one of the oldest biological medicines, and has an established place in the prevention and treatment of venous thrombosis. Low-molecular-weight heparins (LMWH) have been developed by several manufacturers and have advantages in terms of pharmacokinetics and convenience of administration.
Elaine Gray +2 more
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Heparin and Heparin-Like Substances of Cells
1975The correlation between heparin and mast cells was first recognized by Jorpes (7) in 1937, and the history of heparin has since generally been considered to be the history of mast cells. After this correlation was made, however, heparin-like material with lower anticoagulant activity was found by several investigators as a by-product of heparin ...
Cynthia K. Silbert +2 more
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Annals of Internal Medicine, 1984
Excerpt To the editor: We read with interest the article by King and Kelton (1) on the clinical importance of heparin-associated thrombocytopenia.
Erhard Hiller, Hanno Riess
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Excerpt To the editor: We read with interest the article by King and Kelton (1) on the clinical importance of heparin-associated thrombocytopenia.
Erhard Hiller, Hanno Riess
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Heparins and Heparin-Induced Thrombocytopenia
2014This chapter discussed the pharmacology and use of the heparins—standard heparin, low molecular weight heparin, and fondaparinux. The complication of heparin-induced thrombocytopenia is also discussed. Heparin functions as an antithrombotic agent by binding antithrombin (AT), promoting inactivation of the active serine proteases involved in blood ...
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1975
The benefits of reference materials are generally accepted, but their correct use and particularly the limitations on their use are not so well understood. The need for a reference preparation of heparin was recognized before World War II, and the first International Standard for heparin was established in 1942 (20).
D. R. Bangham, Milica Brozović
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The benefits of reference materials are generally accepted, but their correct use and particularly the limitations on their use are not so well understood. The need for a reference preparation of heparin was recognized before World War II, and the first International Standard for heparin was established in 1942 (20).
D. R. Bangham, Milica Brozović
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Heparin, Low Molecular Weight Heparin, and Heparin-Induced Thrombocytopenia in the ICU
Critical Care Clinics, 2005Thrombocytopenia is common in critically ill patients who receive heparin. However, heparin-induced thrombocytopenia (HIT) is a relatively uncommon explanation for thrombocytopenia in this patient population. This article describes clinical features of HIT and interpretation of laboratory tests for HIT antibodies from the perspective of the intensive ...
Theodore E. Warkentin, Deborah J. Cook
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The American Journal of Surgery, 1974
Abstract Gallstones were incubated in a solution of bile and heparinized saline to ascertain if heparin, by changing the zeta potential of the bile, could cause their dissolution. No changes in weight or signs of fragmentation were noted. It was concluded that the disappearance of retained common duct stones by a drip of heparinized saline into a T ...
William C. Butterfield, Roberto Romeǒ
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Abstract Gallstones were incubated in a solution of bile and heparinized saline to ascertain if heparin, by changing the zeta potential of the bile, could cause their dissolution. No changes in weight or signs of fragmentation were noted. It was concluded that the disappearance of retained common duct stones by a drip of heparinized saline into a T ...
William C. Butterfield, Roberto Romeǒ
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Nature, 1952
OBSERVATION of a rapid fall in ‘inorganic phosphate’ of heparinized whole blood and plasma led to study of the phosphate changes in shed blood. The effect of heparin on blood phosphate in vivo has been reported1. Further study of the effect of heparin in vitro led to the view that the action of heparin may be associated with phosphate uptake.
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OBSERVATION of a rapid fall in ‘inorganic phosphate’ of heparinized whole blood and plasma led to study of the phosphate changes in shed blood. The effect of heparin on blood phosphate in vivo has been reported1. Further study of the effect of heparin in vitro led to the view that the action of heparin may be associated with phosphate uptake.
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