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JAMA: The Journal of the American Medical Association, 1974
To the Editor.— The difference in potency of heparin from various tissues is the reason that dosages must be expressed in units of activity rather than in milligrams. Since by United States Pharmacopoeia standards 1 mg of heparin sodium from lung tissue is not less than 120 USP units, while 1 mg of heparin sodium from intestinal mucosa is not less ...
Edward H. Jones, R. David Anderson
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To the Editor.— The difference in potency of heparin from various tissues is the reason that dosages must be expressed in units of activity rather than in milligrams. Since by United States Pharmacopoeia standards 1 mg of heparin sodium from lung tissue is not less than 120 USP units, while 1 mg of heparin sodium from intestinal mucosa is not less ...
Edward H. Jones, R. David Anderson
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Angiology, 1989
Hemodialysis performed with prostacyclin (5 ng/kg/min) as a sub stitute for heparin was studied in 10 patients. The subjects were studied during heparin perfusion alone and during heparin perfusion together with prostacyclin. The authors inves tigated the effect of two heparin regi mens (regimen I: 2,000 U/hr and reg imen II: 500 U/hr) upon plasma ...
CAMICI, MARCELLO, EVANGELISTI L.
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Hemodialysis performed with prostacyclin (5 ng/kg/min) as a sub stitute for heparin was studied in 10 patients. The subjects were studied during heparin perfusion alone and during heparin perfusion together with prostacyclin. The authors inves tigated the effect of two heparin regi mens (regimen I: 2,000 U/hr and reg imen II: 500 U/hr) upon plasma ...
CAMICI, MARCELLO, EVANGELISTI L.
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Heparin, Heparin-Activated Enzymes and Platelets
Pathophysiology of Haemostasis and Thrombosis, 1977This review summarises evidence supporting the view that the therapeutic anticoagulant properties of heparin are related to its physiological function in the organism, especially its activation of lipoprotein lipase and lecithinase. The conflicting results obtained from studies of the effect of heparin on platelet function are discussed, together with ...
J M Ham, J C Lawrence
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Mode of action of heparin lyase on heparin
Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1982Heparinase (heparin lyase, EC 4.2.2.7) prepared from Flavobacterium heparinum was used to digest heparin. The products of digestion were examined with a viscosometric assay at various stages of the reaction to measure their average molecular weight.
Charles L. Cooney +4 more
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Metachromatic activity of heparin and heparin fragments
Analytical Biochemistry, 1984Heparin of an average molecular weight of 13,000 was fractionated on the basis of size into five fractions of different weight-average molecular weight ranging from 8500 to 20,000. The heparin was also degraded using microbial heparinase resulting in products ranging from a disaccharide of molecular weight 500 to an oligosaccharide of molecular weight ...
Robert J. Linhardt +4 more
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Heparin and low-molecular-weight heparin
Thrombosis and Haemostasis, 2008SummaryHeparin is one of the oldest biological medicines, and has an established place in the prevention and treatment of venous thrombosis. Low-molecular-weight heparins (LMWH) have been developed by several manufacturers and have advantages in terms of pharmacokinetics and convenience of administration.
Elaine Gray +2 more
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