Results 321 to 330 of about 522,479 (352)
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Heparin and Heparin-Like Substances of Cells
1975The correlation between heparin and mast cells was first recognized by Jorpes (7) in 1937, and the history of heparin has since generally been considered to be the history of mast cells. After this correlation was made, however, heparin-like material with lower anticoagulant activity was found by several investigators as a by-product of heparin ...
Cynthia K. Silbert +2 more
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Heparin, Low Molecular Weight Heparin, and Heparin-Induced Thrombocytopenia in the ICU
Critical Care Clinics, 2005Thrombocytopenia is common in critically ill patients who receive heparin. However, heparin-induced thrombocytopenia (HIT) is a relatively uncommon explanation for thrombocytopenia in this patient population. This article describes clinical features of HIT and interpretation of laboratory tests for HIT antibodies from the perspective of the intensive ...
Theodore E. Warkentin, Deborah J. Cook
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Annals of Internal Medicine, 1984
Excerpt To the editor: We read with interest the article by King and Kelton (1) on the clinical importance of heparin-associated thrombocytopenia.
Erhard Hiller, Hanno Riess
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Excerpt To the editor: We read with interest the article by King and Kelton (1) on the clinical importance of heparin-associated thrombocytopenia.
Erhard Hiller, Hanno Riess
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1975
The benefits of reference materials are generally accepted, but their correct use and particularly the limitations on their use are not so well understood. The need for a reference preparation of heparin was recognized before World War II, and the first International Standard for heparin was established in 1942 (20).
D. R. Bangham, Milica Brozović
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The benefits of reference materials are generally accepted, but their correct use and particularly the limitations on their use are not so well understood. The need for a reference preparation of heparin was recognized before World War II, and the first International Standard for heparin was established in 1942 (20).
D. R. Bangham, Milica Brozović
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Heparins and Heparin-Induced Thrombocytopenia
2014This chapter discussed the pharmacology and use of the heparins—standard heparin, low molecular weight heparin, and fondaparinux. The complication of heparin-induced thrombocytopenia is also discussed. Heparin functions as an antithrombotic agent by binding antithrombin (AT), promoting inactivation of the active serine proteases involved in blood ...
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1992
Seventy-five years after its discovery (1,2), heparin remains an important tool in medicine. Among its established uses are the prevention of postoperative thrombosis, the treatment of acute venous thrombosis, and the prevention of clot formation in the heart-lung machine (3).
Elias Meezan +7 more
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Seventy-five years after its discovery (1,2), heparin remains an important tool in medicine. Among its established uses are the prevention of postoperative thrombosis, the treatment of acute venous thrombosis, and the prevention of clot formation in the heart-lung machine (3).
Elias Meezan +7 more
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Nature, 1952
OBSERVATION of a rapid fall in ‘inorganic phosphate’ of heparinized whole blood and plasma led to study of the phosphate changes in shed blood. The effect of heparin on blood phosphate in vivo has been reported1. Further study of the effect of heparin in vitro led to the view that the action of heparin may be associated with phosphate uptake.
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OBSERVATION of a rapid fall in ‘inorganic phosphate’ of heparinized whole blood and plasma led to study of the phosphate changes in shed blood. The effect of heparin on blood phosphate in vivo has been reported1. Further study of the effect of heparin in vitro led to the view that the action of heparin may be associated with phosphate uptake.
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1975
Although heparin was isolated in a pure, active form nearly six decades ago by McLean (41), the problems faced in solving its chemical structure have been complex enough that a recent circular (52) addressed to physicians states that “heparin is a heterogeneous substance whose exact structure is still unknown.” Nevertheless, since I wrote (25), in 1958
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Although heparin was isolated in a pure, active form nearly six decades ago by McLean (41), the problems faced in solving its chemical structure have been complex enough that a recent circular (52) addressed to physicians states that “heparin is a heterogeneous substance whose exact structure is still unknown.” Nevertheless, since I wrote (25), in 1958
openaire +3 more sources