Results 331 to 340 of about 724,197 (388)
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Angewandte Chemie - International Edition, 2002
Ishan Capila, Robert J Linhardt
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Ishan Capila, Robert J Linhardt
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Journal of the American Chemical Society, 2015
Li-Jun Chen, Nai-Wei Wu, Hong-Wei Tan
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Li-Jun Chen, Nai-Wei Wu, Hong-Wei Tan
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JAMA: The Journal of the American Medical Association, 1974
To the Editor.— The difference in potency of heparin from various tissues is the reason that dosages must be expressed in units of activity rather than in milligrams. Since by United States Pharmacopoeia standards 1 mg of heparin sodium from lung tissue is not less than 120 USP units, while 1 mg of heparin sodium from intestinal mucosa is not less ...
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To the Editor.— The difference in potency of heparin from various tissues is the reason that dosages must be expressed in units of activity rather than in milligrams. Since by United States Pharmacopoeia standards 1 mg of heparin sodium from lung tissue is not less than 120 USP units, while 1 mg of heparin sodium from intestinal mucosa is not less ...
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Current Opinion in Hematology, 2002
Fondaparinux (a synthetic heparin analogue) (Sanofi-Synthelabo; Paris, France and Organon Research; Oss, The Netherlands) is the subject of intense recent clinical evaluation for the prevention and treatment of venous and arterial thromboembolism. The drug replicates the sulphated antithrombin-binding pentasaccharide sequence in heparin and induces ...
Alexander S, Gallus, Douglas W, Coghlan
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Fondaparinux (a synthetic heparin analogue) (Sanofi-Synthelabo; Paris, France and Organon Research; Oss, The Netherlands) is the subject of intense recent clinical evaluation for the prevention and treatment of venous and arterial thromboembolism. The drug replicates the sulphated antithrombin-binding pentasaccharide sequence in heparin and induces ...
Alexander S, Gallus, Douglas W, Coghlan
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2011
Explorations of the therapeutic potential of heparin mimetics, anionic compounds that are analogues of glycosaminoglycans (GAGs), have gone hand-in-hand with the emergence of understanding as to the role of GAGs in many essential biological processes.
Coombe, Deidre, Kett, W.
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Explorations of the therapeutic potential of heparin mimetics, anionic compounds that are analogues of glycosaminoglycans (GAGs), have gone hand-in-hand with the emergence of understanding as to the role of GAGs in many essential biological processes.
Coombe, Deidre, Kett, W.
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2011
Heparin and heparan sulfate share the same polysaccharide backbone structure but differ in sulfation degree and expression pattern. Whereas heparan sulfate is found in virtually all cells of the human body, heparin expression is restricted to mast cells, where it has a function in storage of granular components such as histamine and mast cell specific ...
Pernilla, Carlsson, Lena, Kjellén
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Heparin and heparan sulfate share the same polysaccharide backbone structure but differ in sulfation degree and expression pattern. Whereas heparan sulfate is found in virtually all cells of the human body, heparin expression is restricted to mast cells, where it has a function in storage of granular components such as histamine and mast cell specific ...
Pernilla, Carlsson, Lena, Kjellén
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Pathophysiology of Haemostasis and Thrombosis, 1990
Heparins used in therapy are largely constituted by sequences of the trisulfated disaccharide <i>L</i>-iduronic acid-2-sulfate→<i>D</i>-glucosamine-N,6-disulfate. These regular sequences are interrupted by undersulfated (occasionally, oversulfated) sequences containing <i>D</i>-glucuronic acid and N-acetylated <i ...
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Heparins used in therapy are largely constituted by sequences of the trisulfated disaccharide <i>L</i>-iduronic acid-2-sulfate→<i>D</i>-glucosamine-N,6-disulfate. These regular sequences are interrupted by undersulfated (occasionally, oversulfated) sequences containing <i>D</i>-glucuronic acid and N-acetylated <i ...
openaire +2 more sources