Results 51 to 60 of about 56,941 (257)

CXCL10/SLC11A1 Axis Exacerbates Septic Liver Injury by Regulating Neutrophil Extracellular Traps Formation to Drive Macrophage Pro‑Inflammatory Polarization

Advanced Science, EarlyView.
In sepsis‐induced liver injury, marked neutrophil infiltration correlates with disease severity. Neutrophil SLC11A1 drives intracellular Fe2+ and ROS via the Fenton reaction, promoting NETs formation. Hepatocyte‐derived CXCL10 recruits neutrophils and activates the JAK/STAT1/SLC11A1 axis, enhancing NETs‐mediated inflammation.
Haiping Lin, Shicong Zheng, Pei Song, Jie Chang, Zewei Chen, Cang Li, Min Yu, Lude Wang, Shian Yu   +8 more
wiley   +1 more source

Repeat hepatectomy with systemic chemotherapy might improve survival of recurrent liver metastasis from colorectal cancer—a retrospective observational study

World Journal of Surgical Oncology, 2019
Background Although hepatectomy for metastatic colorectal cancer (mCRC) prolongs survival in up to 40% of people, recurrence rates approach 70%. We used a multidisciplinary approach to treat recurrent liver metastases, including chemotherapy, surgery ...
Hiroshi Matsuoka, Zenichi Morise, Chihiro Tanaka, Takahiro Hayashi, Yoshiaki Ikeda, Koutarou Maeda, Koji Masumori, Yoshikazu Koide, Hidetoshi Katsuno, Yoshinao Tanahashi, Sanae Nakajima, Tsunekazu Hanai, Yutaro Kato, Atsushi Sugioka, Ichiro Uyama   +14 more
doaj   +1 more source

Robotic versus laparoscopic hepatectomy for malignancy: A systematic review and meta-analysis

Asian Journal of Surgery, 2021
The aim of this study was to compare the clinical safety and efficacy of robotic hepatectomy (RH) versus conventional laparoscopic hepatectomy (LH) for malignancy using meta-analysis.
Yingnan Hu, Kaibo Guo, Jingming Xu, Taotao Xia, Tingting Wang, Nan Liu, Yongqing Fu   +6 more
doaj   +1 more source

RGS16 Aggravates Hepatic Ischemia‐Reperfusion Injury via Hepatocyte‐Intrinsic Apoptosis/Inflammation & Neutrophil Recruitment/NETosis

Advanced Science, EarlyView.
RGS16 competitively interferes with the YTHDF3–PAN3 complex to prevent CXCL1 mRNA decay during hepatic ischemia‐reperfusion injury. Stabilized CXCL1 strengthens hepatocyte injury, neutrophil recruitment, and NET‐associated inflammation, uncovering how stress‐induced RGS16 converts post‐transcriptional regulation into immune‐mediated liver damage ...
Xinglong Li, Zhanzhi Meng, Hongjun Yu, Yongliang Hua, Zihao Li, Bing Yin, Baolin Qian, Zhongyu Li, Yongzhi Zhou, Zhigang Feng, Shounan Lu, Shanjia Ke, Miaoyu Bai, Yao Fu, Wei Tang, Natalia V. Belosludtseva, Yong Ma   +16 more
wiley   +1 more source

ประสิทธิภาพของ tranexamic acid ในการลดการเสียเลือดระหว่างการผ่าตัด hepatectomy

, 2022
Introduction: Hepatectomy is a complex surgery with high risk of bleeding. Tranexamic acid (TXA) administration has been proved to reduce intraoperative bleeding in many major surgeries. However, the efficacy of TXA to reduce blood loss in hepatectomy is
Sukyoo, Danaiporn, Sathitkarnmanee, Benjaporn   +1 more
core   +1 more source

Prediction of postoperative complications after hepatectomy with dynamic monitoring of central venous oxygen saturation

BMC Surgery, 2023
Background The usefulness of static monitoring using central venous pressure has been reported for anesthetic management in hepatectomy. It is unclear whether intra-hepatectomy dynamic monitoring can predict the postoperative course.
Shinya Ida, Yoshifumi Morita, Akio Matsumoto, Ryuta Muraki, Ryo Kitajima, Satoru Furuhashi, Makoto Takeda, Hirotoshi Kikuchi, Yoshihiro Hiramatsu, Hiroya Takeuchi   +9 more
doaj   +1 more source

Bloodless hepatectomy technique [PDF]

HPB, 2002
Surgical resection remains the gold standard in dealing with liver tumours. Blood loss, biliary leak and postoperative liver function are still the main concerns of surgeons operating on the liver, even though different techniques have been developed to allow safer liver resection. A novel concept for liver resection is described using a radiofrequency
Navarra, G., Spalding, D., Zacharoulis, D., Nicholls, J.P., Kirby, S., Costa, I., Habib, N.A.   +6 more
openaire   +2 more sources

Hepatic microcirculation after hepatectomy.

, 2015
Hepatic microcirculation after 30%, 70% and 90% hepatectomy. Baseline conditions without hepatectomy (con) served as controls.
Matthias W. Laschke (434593), Claudia Scheuer (434594), Sven Richter (820787), Stefan Dold (820786), Brigitte Vollmar (22920), Martin K. Schilling (820790), Otto Kollmar (820788), Michael D. Menger (375581), Maximilian von Heesen (820789)   +8 more
core   +1 more source

Comparison of the prognostic influence of emergency hepatectomy and staged hepatectomy in patients with ruptured hepatocellular carcinoma [PDF]

, 2016
BackgroundSpontaneous hepatocellular carcinoma (HCC) rupture is a fatal complication of primary liver cancer and is associated with poor surgical outcomes.
Zeng, Zhijun, Luo, Yijiang, Lianyue Yang, Yang, Lianyue, Yang, Hao, Dipeng Ou, Zhijun Zeng, Ou, Dipeng, Hao Yang, Yijiang Luo   +9 more
core   +1 more source

Nucleoside‐Modified mRNA Encoding Alpha‐Galactosidase A Ameliorates Fabry Disease Phenotypes in Human IPSC‐Derived Cardiomyocytes

Advanced Science, EarlyView.
Human iPSC‐derived Fabry cardiomyocytes exhibited broad transcriptional dysregulation, apoptosis, mitochondrial dysfunction, impaired reactive oxygen species handling, altered contractility, and abnormal calcium transient decay, potentially mediated by phospholamban hyperphosphorylation.
Malte Juchem, Lea Oehlsen, Sedef Ersoy, Jia Li Ye, Natalie Weber, Elisa Mohr, Wilson Agyapong, Junqing Liu, Maximilian Fuchs, Ke Xiao, Christopher Jahn, Reto Eggenschwiler, Tobias Cantz, Julia Beimdiek, Falk F. R. Buettner, Theresia Kraft, Jan Hegermann, Ivonne J. Knorr, Lisa Ernst, Linda Feldbrügge, Resa Puffert, Kevin Schmidt, Christian Bär, Jeannine Hoepfner, Thomas Thum   +24 more
wiley   +1 more source