Results 31 to 40 of about 41,450 (227)

Study on anxiety and depression in elderly patients with malignant liver tumor undergoing hepatectomy

European Journal of Medical Research, 2023
Background Patients with malignant tumors are more likely to have psychological problems due to their worries about their life expectancy. To understand the psychological status of elderly patients with malignant liver tumor undergoing hepatectomy better,
Lining Xu, Yingying Xu, Guiping Li, Bo Yang   +3 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Predictive value of intra-hepatectomy ICGR15 of the remnant liver for post-hepatectomy liver failure in hemi-hepatectomy: a prospective study

BMC Cancer
Background and objective Post-hepatectomy liver failure (PHLF) is one of the major complications following hepatectomy for hepatocellular carcinoma (HCC). Early identification and precise prediction of PHLF are essential for effective management.
Tianyi Liang, Yongfei He, Shutian Mo, Yuan Liao, Ketuan Huang, Qiang Gao, Xiaoqiang Shen, Chengkun Yang, Xiwen Liao, Wei Qin, Guangzhi Zhu, Hao Su, Xinping Ye, Chuangye Han, Tao Peng   +14 more
doaj   +1 more source

Risk factors of postoperative bile leakage after liver resection: A systematic review and meta‐analysis

Cancer Medicine, 2023
Objective Postoperative bile leakage (POBL) is one of the most common complications after liver resection. However, current studies on the risk factors for POBL and their impacts on surgical outcomes need to be more consistent. This study aims to conduct
Shuai Xue, Haichuan Wang, Xiangzheng Chen, Yong Zeng   +3 more
doaj   +1 more source

Optimized Ex Vivo Human Liver Slice Culture Maintains Extended Viability and Function for Hepatotoxicity Testing

Advanced Science, EarlyView.
An optimized ex vivo human liver slice culture system preserves tissue architecture, hepatocyte function, and immune‐stromal complexity for at least five days. By refining slice thickness, oxygenation, air‐liquid interface, and extracellular matrix support, the platform enables human‐relevant hepatotoxicity testing and mechanistic studies, offering a ...
Huiche Feng, Cinzia Esposito, Andrej Benjak, Matthias S. Matter, Miriam Cieri, Camilla De Carlo, Philipp Sedlaczek, Fabian Haak, Mattia Marinucci, Gabriel Fridolin Hess, Otto Kollmar, Mairene Coto‐Llerena, Luca Di Tommaso, Visar Vela, Lukas Bubendorf, Luigi M. Terracciano, Charlotte K. Y. Ng, Salvatore Piscuoglio   +17 more
wiley   +1 more source

The usefulness of preoperative bile cultures for hepatectomy with biliary reconstruction

Heliyon, 2022
Background: Infectious complications can cause lethal liver failure after hepatectomy with biliary reconstruction. This study assessed the increased risk for postoperative infectious complications in patients who underwent hepatectomy with biliary ...
Kenta Makino, Takamichi Ishii, Tomoaki Yoh, Satoshi Ogiso, Ken Fukumitsu, Satoru Seo, Kojiro Taura, Etsuro Hatano   +7 more
doaj   +1 more source

Hyperpolarized MRI Detects Increased [1-¹³C]Pyruvate Metabolism in Early Liver Regeneration. [PDF]

NMR Biomed
Hyperpolarized [1‐13C]pyruvate MRI detected increased pyruvate‐to‐lactate and pyruvate‐to‐alanine exchange during early liver regeneration following 70% partial hepatectomy in rats. These findings support the use of hyperpolarized MRI for noninvasive assessment of regenerative metabolism.
Kjærgaard U, Lund A, Bertelsen LB, Hansen ESS, Andersen KH, Ringgaard S, Nyengaard JR, Mortensen FV, Laustsen C.   +8 more
europepmc   +2 more sources

CXCL10/SLC11A1 Axis Exacerbates Septic Liver Injury by Regulating Neutrophil Extracellular Traps Formation to Drive Macrophage Pro‑Inflammatory Polarization

Advanced Science, EarlyView.
In sepsis‐induced liver injury, marked neutrophil infiltration correlates with disease severity. Neutrophil SLC11A1 drives intracellular Fe2+ and ROS via the Fenton reaction, promoting NETs formation. Hepatocyte‐derived CXCL10 recruits neutrophils and activates the JAK/STAT1/SLC11A1 axis, enhancing NETs‐mediated inflammation.
Haiping Lin, Shicong Zheng, Pei Song, Jie Chang, Zewei Chen, Cang Li, Min Yu, Lude Wang, Shian Yu   +8 more
wiley   +1 more source

Repeat hepatectomy with systemic chemotherapy might improve survival of recurrent liver metastasis from colorectal cancer—a retrospective observational study

World Journal of Surgical Oncology, 2019
Background Although hepatectomy for metastatic colorectal cancer (mCRC) prolongs survival in up to 40% of people, recurrence rates approach 70%. We used a multidisciplinary approach to treat recurrent liver metastases, including chemotherapy, surgery ...
Hiroshi Matsuoka, Zenichi Morise, Chihiro Tanaka, Takahiro Hayashi, Yoshiaki Ikeda, Koutarou Maeda, Koji Masumori, Yoshikazu Koide, Hidetoshi Katsuno, Yoshinao Tanahashi, Sanae Nakajima, Tsunekazu Hanai, Yutaro Kato, Atsushi Sugioka, Ichiro Uyama   +14 more
doaj   +1 more source

Impact of previous history of choledochojejunostomy on the incidence of organ/space surgical site infection after hepatectomy

Asian Journal of Surgery, 2021
Purpose: Impact of previous history of choledochojejunostomy (PCJ) on the incidence of organ/space surgical site infection (SSI) after hepatectomy remains unclear. The aim of this study was to investigate the incidence and causes of SSI after hepatectomy.
Masashi Kudo, Shin Kobayashi, Motohiro Kojima, Tatsushi Kobayashi, Motokazu Sugimoto, Shinichiro Takahashi, Masaru Konishi, Genichiro Ishii, Naoto Gotohda   +8 more
doaj   +1 more source