Results 11 to 20 of about 56,941 (257)

Preoperative FIB-4 Index as a Potential Factor Associated With Severe Postoperative Complications and Endogenous Organ Failure After Hepatectomy for Hepatocellular Carcinoma. [PDF]

Ann Gastroenterol Surg
This study demonstrates that a preoperative FIB‐4 index ≥ 5.0 independently predicts severe complications and endogenous organ failure (EOF) following hepatectomy for hepatocellular carcinoma. By capturing structural liver fragility and systemic vulnerability, the FIB‐4 index enhances surgical risk stratification beyond traditional functional markers ...
Nakamura M, Okamura Y, Aramaki O, Yoshida N, Mitsuka Y, Abe H, Yamagishi S, Okumura Y, Pak K, Masuda S.   +9 more
europepmc   +2 more sources

The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression

Hepatology, EarlyView., 2022
Loss of NOX4 in HCC tumor cells induces metabolic reprogramming in a Nrf2/MYC‐dependent manner to promote HCC progression. Abstract Background and Aims The NADPH oxidase NOX4 plays a tumor‐suppressor function in HCC. Silencing NOX4 confers higher proliferative and migratory capacity to HCC cells and increases their in vivo tumorigenic potential in ...
Irene Peñuelas‐Haro, Rut Espinosa‐Sotelo, Eva Crosas‐Molist, Macarena Herranz‐Itúrbide, Daniel Caballero‐Díaz, Ania Alay, Xavier Solé, Emilio Ramos, Teresa Serrano, María L. Martínez‐Chantar, Ulla G. Knaus, José M. Cuezva, Antonio Zorzano, Esther Bertran, Isabel Fabregat   +14 more
wiley   +1 more source

Major Hepatectomies: Outcome and Perspectives from Eastern Nepal [PDF]

Journal of Clinical and Diagnostic Research, 2018
Introduction: Liver resection is a widely used surgical procedure for different benign and malignant pathology, which carries a significant morbidity and mortality (5-10%). Post-hepatectomy liver failure and bile leak are the major complications of major
Narendra Pandit, Laligen Awale, Shailesh Adhikary   +2 more
doaj   +1 more source

c‐Rel–dependent Chk2 signaling regulates the DNA damage response limiting hepatocarcinogenesis

Hepatology, EarlyView., 2022
In response to genotoxic injury, c‐Rel upregulates ATM‐Chk2‐p53 pathway DNA damage proteins to limiting hepatocarcinogenesis. Abstract Background and Aims Hepatocellular carcinoma (HCC) is a leading cause of cancer‐related death. The NF‐κB transcription factor family subunit c‐Rel is typically protumorigenic; however, it has recently been reported as a
Jack Leslie, Jill E. Hunter, Amy Collins, Amelia Rushton, Lauren G. Russell, Erik Ramon‐Gil, Maja Laszczewska, Misti McCain, Marco Y. W. Zaki, Amber Knox, Yixin Seow, Laura Sabater, Daniel Geh, Neil D. Perkins, Helen L. Reeves, Dina Tiniakos, Derek A. Mann, Fiona Oakley   +17 more
wiley   +1 more source

TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk

Hepatology, EarlyView., 2022
The systematic approach in elucidating the gain‐of‐function (GOF) roles of TP53 mutations in early liver carcinogenesis. Unique downstream targets of TP53 L3 mutations were identified from chormatin immunoprecipitation sequencing in HCC cell lines, followed by a series of validation assays to substantiate the exclusive transcriptional regulations ...
Yin Kau Lam, Jianqing Yu, Hao Huang, Xiaofan Ding, Alissa M. Wong, Howard H. Leung, Anthony W. Chan, Kelvin K. Ng, Mingjing Xu, Xin Wang, Nathalie Wong   +10 more
wiley   +1 more source

Secretagogin Mediates the Regulatory Effect of Electroacupuncture on Hypothalamic-Pituitary-Adrenal Axis Dysfunction in Surgical Trauma

Neural Plasticity, 2021
Electroacupuncture (EA) improves hypothalamic-pituitary-adrenal (HPA) axis disorder by reducing corticotropin-releasing hormone (CRH) synthesis and release in the paraventricular nucleus (PVN).
Mizhen Zhang, Jingxian Sun, Yu Wang, Zhanzhuang Tian   +3 more
doaj   +1 more source

Robotic versus laparoscopic major hepatectomy for hepatocellular carcinoma: short-term outcomes from a single institution

BMC Surgery, 2022
Background Currently, an increasing number of robotic major hepatectomies for hepatocellular carcinoma (HCC) are being performed. Despite the advantages of robotic surgery over laparoscopic procedures, studies comparing robotic with laparoscopic major ...
Linsen Liu, Yan Wang, Tianchong Wu, Jianwei Lin, Lingna Deng, Jiling Jiang, Tailai An   +6 more
doaj   +1 more source

Usefulness of Omental Wrapping to Prevent Biliary Leakage and Delayed Gastric Emptying in Left Hepatectomy [PDF]

, 2012
Background/Aims: To identify the clinical significance of the omental wrapping (OW) technique after left hepatectomy to reduce bile leakage and delayed gastric emptying.
Nanashima, Atsushi, Kunizaki, Masaki, Takeshita, Hiroaki, Sawai, Terumitsu, Nagayasu, Takeshi, Nonaka, Takashi, Abo, Takafumi, Tobinaga, Syuuichi, Hidaka, Shigekazu, Yasutake, Toru   +9 more
core   +1 more source

Changes in quality of life after hepatectomy and living donor liver transplantation [PDF]

, 2012
Background/Aims: Quality of life has become important as an outcome in addition to conventional outcomes such as disease-free and overall survival. In this study, we compared the fluctuations of quality of life after hepatectomy and living donor liver ...
Takatsuki, Mitsuhisa, Hidaka, Masaaki, Soyama, Akihiko, Muraoka, Izumi, Yamanouchi, Kosho, Miyazaki, Kensuke, Inokuma, Takamitsu, Kanematsu, Takashi, Eguchi, Susumu   +8 more
core   +1 more source

Portal Hyperperfusion after Extended Hepatectomy Does Not Induce a Hepatic Arterial Buffer Response (HABR) but Impairs Mitochondrial Redox State and Hepatocellular Oxygenation. [PDF]

PLoS ONE, 2015
Portal hyperperfusion after extended hepatectomy or small-for-size liver transplantation may induce organ dysfunction and failure. The underlying mechanisms, however, are still not completely understood. Herein, we analysed whether hepatectomy-associated
Stefan Dold, Sven Richter, Otto Kollmar, Maximilian von Heesen, Claudia Scheuer, Matthias W Laschke, Brigitte Vollmar, Martin K Schilling, Michael D Menger   +8 more
doaj   +1 more source