Results 21 to 30 of about 59,051 (216)

Changes in quality of life after hepatectomy and living donor liver transplantation [PDF]

, 2012
Background/Aims: Quality of life has become important as an outcome in addition to conventional outcomes such as disease-free and overall survival. In this study, we compared the fluctuations of quality of life after hepatectomy and living donor liver ...
Takatsuki, Mitsuhisa, Hidaka, Masaaki, Soyama, Akihiko, Muraoka, Izumi, Yamanouchi, Kosho, Miyazaki, Kensuke, Inokuma, Takamitsu, Kanematsu, Takashi, Eguchi, Susumu   +8 more
core   +1 more source

The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression

Hepatology, EarlyView., 2022
Loss of NOX4 in HCC tumor cells induces metabolic reprogramming in a Nrf2/MYC‐dependent manner to promote HCC progression. Abstract Background and Aims The NADPH oxidase NOX4 plays a tumor‐suppressor function in HCC. Silencing NOX4 confers higher proliferative and migratory capacity to HCC cells and increases their in vivo tumorigenic potential in ...
Irene Peñuelas‐Haro, Rut Espinosa‐Sotelo, Eva Crosas‐Molist, Macarena Herranz‐Itúrbide, Daniel Caballero‐Díaz, Ania Alay, Xavier Solé, Emilio Ramos, Teresa Serrano, María L. Martínez‐Chantar, Ulla G. Knaus, José M. Cuezva, Antonio Zorzano, Esther Bertran, Isabel Fabregat   +14 more
wiley   +1 more source

Laparoscopic vs. open anatomical hepatectomy for intrahepatic cholangiocarcinoma: A retrospective cohort study

Frontiers in Surgery, 2022
BackgroundIntrahepatic cholangiocarcinoma is a highly malignant and invasive cancer originating from biliary epithelial cells. The current study was designed to evaluate the feasibility, safety, and clinical outcomes of laparoscopic anatomical ...
Jianlei Wang, Delin Ma, Gang Du, Baokun An, Tong Xia, Tao Zhou, Qingmei Sun, Fengyue Liu, Yadong Wang, Deling Sui, Xiangyu Zhai, Bin Jin   +11 more
doaj   +1 more source

c‐Rel–dependent Chk2 signaling regulates the DNA damage response limiting hepatocarcinogenesis

Hepatology, EarlyView., 2022
In response to genotoxic injury, c‐Rel upregulates ATM‐Chk2‐p53 pathway DNA damage proteins to limiting hepatocarcinogenesis. Abstract Background and Aims Hepatocellular carcinoma (HCC) is a leading cause of cancer‐related death. The NF‐κB transcription factor family subunit c‐Rel is typically protumorigenic; however, it has recently been reported as a
Jack Leslie, Jill E. Hunter, Amy Collins, Amelia Rushton, Lauren G. Russell, Erik Ramon‐Gil, Maja Laszczewska, Misti McCain, Marco Y. W. Zaki, Amber Knox, Yixin Seow, Laura Sabater, Daniel Geh, Neil D. Perkins, Helen L. Reeves, Dina Tiniakos, Derek A. Mann, Fiona Oakley   +17 more
wiley   +1 more source

Vitamin E Attenuates the Progression of Non-Alcoholic Fatty Liver Disease Caused by Partial Hepatectomy in Mice. [PDF]

PLoS ONE, 2015
The progression of non-alcoholic fatty liver disease (NAFLD) likely involves a 'multiple hit' mechanism. We hypothesized that partial hepatectomy, a procedure performed frequently in patients with NAFLD, would accelerate the progression of disease.C57BL ...
Golnar Karimian, Marc Kirschbaum, Zwanida J Veldhuis, Fernanda Bomfati, Robert J Porte, Ton Lisman   +5 more
doaj   +1 more source

TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk

Hepatology, EarlyView., 2022
The systematic approach in elucidating the gain‐of‐function (GOF) roles of TP53 mutations in early liver carcinogenesis. Unique downstream targets of TP53 L3 mutations were identified from chormatin immunoprecipitation sequencing in HCC cell lines, followed by a series of validation assays to substantiate the exclusive transcriptional regulations ...
Yin Kau Lam, Jianqing Yu, Hao Huang, Xiaofan Ding, Alissa M. Wong, Howard H. Leung, Anthony W. Chan, Kelvin K. Ng, Mingjing Xu, Xin Wang, Nathalie Wong   +10 more
wiley   +1 more source

Adjuvant transcatheter arterial chemoembolization after curative resection for hepatocellular carcinoma patients with solitary tumor and microvascular invasion: a randomized clinical trial of efficacy and safety

Cancer Communications, 2018
Background The optimal strategy for adjuvant therapy after curative resection for hepatocellular carcinoma (HCC) patients with solitary tumor and microvascular invasion (MVI) is controversial.
Wei Wei, Pei-En Jian, Shao-Hua Li, Zhi-Xing Guo, Yong-Fa Zhang, Yi-Hong Ling, Xiao-Jun Lin, Li Xu, Ming Shi, Lie Zheng, Min-Shan Chen, Rong-Ping Guo   +11 more
doaj   +1 more source

Laparoscopic living‐donor hepatectomy: Review of its current status

Annals of Gastroenterological Surgery, 2021
The laparoscopic living‐donor hepatectomy procedure has been developing rapidly. Although its use has increased worldwide, it is still only performed by experienced surgeons at a limited number of institutions.
Shigeru Marubashi, Hiroaki Nagano
doaj   +1 more source

Prediction of portal pressure from intraoperative ultrasonography [PDF]

, 2014
Background Portal hypertension is a major risk factor for hepatic failure or bleeding in patients who have undergone hepatectomy, but it cannot be measured indirectly.
Tominaga, Tetsuro, Nanashima, Atsushi, Arai, Junichi, Nagayasu, Takeshi, Furukawa, Katsuro, Abo, Takafumi, Takagi, Katsunori, Mochinaga, Koji   +7 more
core   +1 more source

Hepatectomy leads to loss of TRAIL-expressing liver NK cells via downregulation of the CXCL9-CXCR3 axis in mice. [PDF]

PLoS ONE, 2017
Liver-resident natural killer (NK) cells express TNF-related apoptosis-inducing ligand (TRAIL), a critical molecule for NK cell-mediated tumor cell killing.
Takuya Yano, Masahiro Ohira, Ryosuke Nakano, Yuka Tanaka, Hideki Ohdan   +4 more
doaj   +1 more source