Results 61 to 70 of about 474,410 (300)

The regulatory role of IL-6R in hepatitis B-associated fibrosis and cirrhosis

Brazilian Journal of Medical and Biological Research, 2017
This study investigated the expression and regulation of IL-6R in hepatitis B-associated moderate hepatic fibrosis and cirrhosis. Liver tissues, peripheral blood monocytes (PBMs) and serum were collected from 26 hepatitis B patients with liver fibrosis ...
Y. Chen, S. Yang, Y. Peng, Z. Yang
doaj   +1 more source

TRAIP Mediates Alcohol‐Induced Liver Injury through Regulating β‐catenin Ubiquitin Degradation via Direct Interaction

Advanced Science, EarlyView.
This study reveals that NF‐κB1‐driven TRAIP upregulation in ALD correlates with disease severity. Mechanistically, TRAIP directly binds β‐catenin via its CC domain and promotes its K48‐linked ubiquitination and degradation, which is independent of the GSK3β/β‐TrCP pathway.
Zhan Wu, Mingjiang Liu, Lijuan Liao, Zhaohong Mo, Wenli Xu, Linfeng Mao, Yubing Chen, Qiuli Xie, Ming Yao, Shilian Chen, Stephen Tomlinson, Sebastian Mueller, Songqing He, Guandou Yuan   +13 more
wiley   +1 more source

Intestinal peroxisome proliferator‐activated receptor α‐fatty acid‐binding protein 1 axis modulates nonalcoholic steatohepatitis

Hepatology, EarlyView., 2022
Abstract Background and Aims Peroxisome proliferator‐activated receptor α (PPARα) regulates fatty acid transport and catabolism in liver. However, the role of intestinal PPARα in lipid homeostasis is largely unknown. Here, intestinal PPARα was examined for its modulation of obesity and NASH. Approach and Results Intestinal PPARα was activated and fatty
Tingting Yan, Yuhong Luo, Nana Yan, Keisuke Hamada, Nan Zhao, Yangliu Xia, Ping Wang, Changdong Zhao, Dan Qi, Shoumei Yang, Lulu Sun, Jie Cai, Qiong Wang, Changtao Jiang, Oksana Gavrilova, Kristopher W. Krausz, Daxesh P. Patel, Xiaoting Yu, Xuan Wu, Haiping Hao, Weiwei Liu, Aijuan Qu, Frank J. Gonzalez   +22 more
wiley   +1 more source

Hepatic Sarcoidosis Presenting as Portal Hypertension and Liver Cirrhosis: Case Report and Review of the Literature

Case Reports in Gastroenterology, 2012
Systemic sarcoidosis is a disease of unknown etiology, with the liver being the third most commonly affected organ. Most cases of hepatic sarcoidosis are not clinically apparent, but a few can progress to liver cirrhosis, portal hypertension and ...
Christopher B. Tan, Sadat Rashid, Dhyan Rajan, Wondwoosen Gebre, Paul Mustacchia   +4 more
doaj   +1 more source

Determination of Diagnostic Accuracy of Aspartate Aminotransferase/Alanine Aminotranferase in Patients with Hepatic Cirrhosis Presented at Tertiary Care Hospital of South Punjab Pakistan

Pakistan Armed Forces Medical Journal, 2022
Objective: To determine the diagnostic accuracy of Aspartate aminotransferase/Alanine aminotransferase ratio in hepatic cirrhosis keeping liver biopsy as a reference standard. Study Design: Cross-sectional analytical study.
Amna Younas, Waqas Hanif, Muhammad Ali Ahmad Sheikh, Muhammad Younas, Sana Ellahi, Qurat ul Ain   +5 more
doaj   +1 more source

Use of piretanide, a new loop diuretic in cirrhosis with ascites. Relationship between the diuretic response and the plasma aldosterone level [PDF]

, 1980
Twenty patients with cirrhosis and ascites but no renal failure were given piretanide, a new loop diuretic, in order to investigate its efficacy and to relate the diuretic response with the pretreatment plasma aldosterone concentration.
Rivera Fillat, Francisca, Rodés, J., Arroyo, Vicente, Casamitjana i Abellà, Roser, Cabrera, J., Bosch i Genover, Jaume   +5 more
core   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

NAFLD‐related hepatocellular carcinoma: The growing challenge

Hepatology, EarlyView., 2022
Risk and protective factors for NAFLD‐related hepatocellular carcinoma Abstract Hepatocellular carcinoma (HCC) is a common cause of cancer‐related mortality and morbidity worldwide. With the obesity pandemic, NAFLD‐related HCC is contributing to the burden of disease exponentially.
Pir Ahmad Shah, Rashmee Patil, Stephen A. Harrison   +2 more
wiley   +1 more source

FREQUENCY OF ABNORMAL HEPATIC VENOUS WAVEFORMS IN CIRRHOTIC PATIENTS

Pakistan Armed Forces Medical Journal, 2015
Objective: To determine the frequency of abnormal hepatic venous waveforms in patients suffering from hepatic cirrhosis. Study Design: Cross sectional.
Syed Atif Hussain Andrabi, Muhammad Nafees, Irfan ul Haq   +2 more
doaj   +2 more sources

Liver Cirrhosis and Sleep Disorders

Portal Hypertension & Cirrhosis
Patients with liver cirrhosis frequently face numerous health challenges, and sleep disorders are often overlooked. Recent studies have indicated that hepatic cirrhosis not only impairs liver function but may also precipitate or exacerbate a decline in ...
Jiawen Feng, Wei Zhang, Qing Ye
doaj   +1 more source