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Nature Reviews Disease Primers, 2022 Hepatic encephalopathy (HE) is a prognostically relevant neuropsychiatric syndrome that occurs in the course of acute or chronic liver disease. Besides ascites and variceal bleeding, it is the most serious complication of decompensated liver cirrhosis.
Dieter Häussinger +2 more
exaly +12 more sources
Neurology, 1993 The approach to the management of patients with HE is summarized in Table 3. Other diagnoses need to be excluded and, after a diagnosis of HE is made on clinical and possibly electroencephalographic grounds, a search made for precipitants. Sedatives and opiates should be avoided, and steps taken to avoid hypoglycaemia, fluid overload or electrolyte ...
Harold O. Conn
+7 more sources
Management of hepatic encephalopathy. [PDF]
Journal of Gastroenterology and Hepatology, 1981 Abstract Hepatic encephalopathy (HE) is seen as a clinical manifestation of low grade chronic cerebral edema, which is accompanied by alterations in glioneural communication. Different factors such as ammonia, inflammatory cytokines, benzodiazepines and electrolyte imbalances may precipitate or aggravate glia edema, thereby explaining precipitation of
Dieter Häussinger, Gerald Kircheis
openalex +5 more sources
DMW - Deutsche Medizinische Wochenschrift, 2001 Hepatic encephalopathy (HE) is a reversible syndrome of impaired brain function occurring in patients with advanced liver diseases. The precise pathophysiology of HE is still under discussion; the leading hypothesis focus on the role of neurotoxins, impaired neurotransmission due to metabolic changes in liver failure, changes in brain energy metabolism,
Srinivasan Dasarathy, Kevin D. Mullen
+15 more sources
Saudi Journal of Gastroenterology, 2012 Chronic liver disease and cirrhosis affect hundreds of millions of patients all over the world. The majority of patients with cirrhosis will eventually develop complications related to portal hypertension. One of these recurrent and difficult to treat complications is hepatic encephalopathy.
Wissam Bleibel, Abdullah M. S. Al-Osaimi
+10 more sources
Veterinary Clinics of North America: Small Animal Practice, 2017 This article reviews hepatic encephalopathy (HE) in companion animals. Clinical signs and categories of hepatic disease likely to cause HE are discussed. Ammonia has a key role in pathogenesis and current concepts in body ammonia metabolism are reviewed. Inflammation and manganese accumulation are also thought to be important in pathogenesis. Treatment
openaire +6 more sources
Rifaximin Treatment in Hepatic Encephalopathy [PDF]
, 2010 Background Hepatic encephalopathy is a chronically debilitating complication of hepatic cirrhosis. The efficacy of rifaximin, a minimally absorbed antibiotic, is well documented in the treatment of acute hepatic encephalopathy, but its efficacy for ...
Bass, Nathan M. +16 more
core +2 more sources
Neuropsychiatric performance and treatment of hepatitis C with direct-acting antivirals: a prospective study [PDF]
, 2017 Background: Since direct-acting antivirals (DAAs) have been approved for the treatment of hepatitis C virus (HCV) infection, a small series of patients with new-onset neuropsychiatric alterations have been referred to us.
Amodio, Piero +11 more
core +1 more source
Bromocriptine-associated ototoxicity [PDF]
, 2007 Three patients treated with bromocriptine for chronic hepatic encephalopathy showed audiometric evidence of bilateral sensori-neural hearing-loss. Audiometrically, the hearing improved in all three patients when the bromocriptine dosage was reduced, thus
Ballantyne, J, Lanthier, PL, Morgan, MY
core +1 more source