Results 41 to 50 of about 51,855 (253)
Egyptian Liver Journal, 2021 Background Hepatic encephalopathy exacerbates the morbidity, delays hospital discharge, and increases the rate of readmissions of cirrhotic patients, particularly those are admitted by acute variceal bleeding.
Rehab Elsayed Elsafty +3 more
doaj +1 more source
Advanced Science, EarlyView.This review explains how chronic liver injury progresses toward hepatocellular carcinoma through interconnected changes in gut microbes, metabolism, immunity, fibrosis, and diet. It highlights microbial metabolites, bile‐acid signaling, immune dysfunction, and nutritional or microbiome‐based interventions as opportunities to identify risk earlier ...
Yi Hu +5 more
wiley +1 more source
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT Progressive familial intrahepatic cholestasis (PFIC) is classically caused by biallelic pathogenic variants, yet monoallelic variants of uncertain significance (VUS) in PFIC‐associated genes are increasingly identified in children with cholestasis, creating diagnostic uncertainty.
Brett J. Hoskins +9 more
wiley +1 more source
Recent advances in hepatic encephalopathy [version 1; referees: 4 approved]
F1000Research, 2017 Hepatic encephalopathy describes the array of neurological alterations that occur during acute liver failure or chronic liver injury. While key players in the pathogenesis of hepatic encephalopathy, such as increases in brain ammonia, alterations in ...
Victoria Liere +2 more
doaj +1 more source
Novelty in Biomedicine, 2022 Background: The mechanism of cerebral dysfunction in hepatic encephalopathy is unknown, although ammonia produced by intestinal bacteria is an essential factor.
Majid Iranshahi Iranshahi +2 more
doaj +1 more source
Animal Models and Experimental Medicine, EarlyView.Schematic diagram of the core pathways of the liver‐brain axis in regulating AD. The liver regulates cerebral Aβ deposition, tau phosphorylation, and neuroinflammation through pathways such as metabolic detoxification (urea cycle, ketone body metabolism, glutathione antioxidant system), molecular secretion (APOE, CRP, FGF21, IGF‐1), and Aβ clearance ...
Ning Zhang, Wei Chen, Meng Wang
wiley +1 more source
Pathogenesis of hepatic encephalopathy [PDF]
Metabolic Brain Disease, 1987 METABOLIC ALTERATIONS IN HEPATIC FAILURE A multitude of changes in metabolic processes occurs with hepatic failure. It is therefore particularly important to distinguish between correlations and causes when considering the pathogenesis of hepatic coma. The etiology appears to be multifactorial. First, to be considered a causative factor, an abnormality
openaire +4 more sources
Concise review of current concepts on nomenclature and pathophysiology of hepatic encephalopathy
Medicina, 2014 Hepatic encephalopathy is a neuropsychiatric complication of liver cirrhosis the symptoms of which may vary from imperceptible to severe, invaliding, and even lethal.
Ilona Savlan +2 more
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Annals of Hepatology, 2023 Introduction and Objectives: In Guatemala, liver cirrhosis has a mortality rate of 41 per 100,000 inhabitants. Diminished physical reserve (frailty) is an important prognostic factor, largely determined by sarcopenia, which in turn has a role in the ...
Katherine Maldonado, Abel Sánchez
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British Journal of Clinical Pharmacology, EarlyView.Aims Paediatric pharmacokinetics differ significantly from adults due to age‐related physiological changes, necessitating precise dose adjustments. However, data on therapeutic drug monitoring (TDM) implementation in paediatric setting remain limited.
Gianluca Gazzaniga +20 more
wiley +1 more source