Results 51 to 60 of about 58,715 (292)

The Peripheral Benzodiazepine Receptor and Neurosteroids in Hepatic Encephalopathy

Hepatic encephalopathy (HE) represents one of the most common events in terminal liver failure. Acute HE (fulminant hepatic failure, FHF) presents with the abrupt onset of delirium, seizures, and coma, and has a mortality rate of about 90%. The principal
Norenberg, Michael D, Itzhak, Yossef, Bender, Alex S   +2 more
core   +2 more sources

Ammonia Detoxification Inhibits Liver Metastasis by Reshaping Hepatic Microenvironment

Advanced Science, EarlyView.
Liver metastasis diverts aspartate into hyperactive pyrimidine synthesis, disrupting urea cycling and causing pathogenic ammonia accumulation. Ammonia dually reprograms the microenvironment by: (1) activating hepatic stellate cells (HSCs) into pro‐fibrotic metastasis‐associated fibroblasts (MAFs), and (2) suppressing anti‐tumor monocytes/macrophages ...
Sumin Sun, Haili Hu, Long Chen, Yuan Gao, Peng Sun, Liming Chen   +5 more
wiley   +1 more source

Assessment of the Therapeutic Effect of Polyethylene glycol and Lactulose in Patients with Hepatic Encephalopathy

Novelty in Biomedicine, 2022
Background: The mechanism of cerebral dysfunction in hepatic encephalopathy is unknown, although ammonia produced by intestinal bacteria is an essential factor.
Majid Iranshahi Iranshahi, Parviz Amri, Mohamad Amri   +2 more
doaj   +1 more source

Microglia‐Targeted Biomimetic Tetrahedral Framework Nucleic Acid Nanovesicles for Synergistic Treatment of Sepsis‐Associated Encephalopathy

Advanced Science, EarlyView.
Sepsis‐associated encephalopathy (SAE) lacks effective therapies. We developed ME@FDsi, a biomimetic nanodrug using a tetrahedral framework nucleic acid to deliver disulfiram and siTNFα. It crosses the blood‐brain barrier, targets M1 microglia, inhibits pyroptosis and inflammation, and scavenges ROS.
Huimin Shi, Qiuxia Gao, Wenying Wang, Bin Li, Yukun Chen, Zhijun Yao, Yujie Li, Junrui Li, Na Li, Gong Gu, Zhimin Hou, Mengyuan Yang, Ruilin Zhang, Hongju Yang, Yuhui Liao, Hongyi Lei   +15 more
wiley   +1 more source

Concise review of current concepts on nomenclature and pathophysiology of hepatic encephalopathy

Medicina, 2014
Hepatic encephalopathy is a neuropsychiatric complication of liver cirrhosis the symptoms of which may vary from imperceptible to severe, invaliding, and even lethal.
Ilona Savlan, Valentina Liakina, Jonas Valantinas   +2 more
doaj   +1 more source

P- 17 FRAILTY AND COVERT HEPATIC ENCEPHALOPATHY IN CIRRHOTIC PATIENTS AT A THIRD LEVEL HOSPITAL IN GUATEMALA

Annals of Hepatology, 2023
Introduction and Objectives: In Guatemala, liver cirrhosis has a mortality rate of 41 per 100,000 inhabitants. Diminished physical reserve (frailty) is an important prognostic factor, largely determined by sarcopenia, which in turn has a role in the ...
Katherine Maldonado, Abel Sánchez
doaj   +1 more source

Therapeutic drug monitoring of antimicrobials in a paediatric setting: A retrospective single‐centre study

British Journal of Clinical Pharmacology, EarlyView.
Aims Paediatric pharmacokinetics differ significantly from adults due to age‐related physiological changes, necessitating precise dose adjustments. However, data on therapeutic drug monitoring (TDM) implementation in paediatric setting remain limited.
Gianluca Gazzaniga, Stefano Agliardi, Riccardo Giossi, Alice Schianchi, Alessandra Romandini, Thomas Virdis, Silvia Nerini Molteni, Maria Luisa De Angelis, Stefania Paccagnini, Cecilia Gechtman, Alice Proto, Marco Fossati, Silvia Oliveri, Giulia Angela Pattarino, Elena Altieri, Agnese Graziosi, Arianna Pani, Romano Danesi, Stefano Martinelli, Costantino De Giacomo, Francesco Scaglione   +20 more
wiley   +1 more source

Incisional hernia as an unusual cause of hepatic encephalopathy in a 62-year-old man with cirrhosis: a case report

Journal of Medical Case Reports, 2009
Introduction Hepatic encephalopathy may be initiated by many factors such as gastrointestinal bleeding, infections, fluid and electrolyte disturbances.
Ustaoglu Muge, Bakir Tulay, Bektas Ahmet, Cure Osman, Gungor Bulent   +4 more
doaj   +1 more source

The treatment of hepatic encephalopathy

, 2007
Current recommendations for the treatment of hepatic encephalopathy are based, to a large extent, on open or uncontrolled trials, undertaken in very small numbers of patients.
M. Y. Morgan, R. Jalan, G. Marchesini, Karin Weissenborn, G. Kircheis, RIGGIO, Oliviero, MARCHESINI REGGIANI, GIULIO, A. Blei, K. Weissenborn, W. Fleig, K. Grungreiff, Marsha Y. Morgan, O. Riggio   +12 more
core   +1 more source

The interplay between molecular architecture, pharmacology, and suspected adverse drug reactions associated with nonsteroidal androgen antagonists in the United Kingdom

British Journal of Clinical Pharmacology, EarlyView.
Aims This work aimed to correlate potential links between the suspected adverse drug reaction (ADR) profile of licensed nonsteroidal androgen receptor antagonists (NSARA) with their unique chemical properties and known off‐target polypharmacology. Methods Physicochemical and polypharmacology data were curated from the Electronic Medicines Compendium ...
Simrit Dhillon, Albert A. Antolin, Alan M. Jones   +2 more
wiley   +1 more source