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Science Translational Medicine, 2023
Advanced hepatic fibrosis, driven by the activation of hepatic stellate cells (HSCs), affects millions worldwide and is the strongest predictor of mortality in nonalcoholic steatohepatitis (NASH); however, there are no approved antifibrotic therapies. To
Shuang Wang +18 more
semanticscholar +1 more source
Advanced hepatic fibrosis, driven by the activation of hepatic stellate cells (HSCs), affects millions worldwide and is the strongest predictor of mortality in nonalcoholic steatohepatitis (NASH); however, there are no approved antifibrotic therapies. To
Shuang Wang +18 more
semanticscholar +1 more source
Biofactors, 2021
Targeting the elimination of activated hepatic stellate cells (HSCs) and blocking excessive deposition of extracellular matrix are recognized as an effective strategy for the treatment of hepatic fibrosis. As a newly discovered programmed cell death mode,
Zili Zhang +9 more
semanticscholar +1 more source
Targeting the elimination of activated hepatic stellate cells (HSCs) and blocking excessive deposition of extracellular matrix are recognized as an effective strategy for the treatment of hepatic fibrosis. As a newly discovered programmed cell death mode,
Zili Zhang +9 more
semanticscholar +1 more source
Role of fibroblast growth factor signalling in hepatic fibrosis
Liver international (Print), 2021Fibrotic remodelling is a highly conserved protective response to tissue injury and it is essential for the maintenance of structural and functional tissue integrity.
T. Seitz, C. Hellerbrand
semanticscholar +1 more source
Journal of Hepatology, 1988
We report the clinical features of 7 men (mean age 22 years, range 7-53 years) with congenital hepatic fibrosis (CHF). Five patients presented with variceal bleeding and/or hepatosplenomegaly due to portal hypertension. Cholangitis was the presenting symptom in the other 2 cases. Diagnosis was established by histological examination of a surgical wedge
M, De Vos, F, Barbier, C, Cuvelier
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We report the clinical features of 7 men (mean age 22 years, range 7-53 years) with congenital hepatic fibrosis (CHF). Five patients presented with variceal bleeding and/or hepatosplenomegaly due to portal hypertension. Cholangitis was the presenting symptom in the other 2 cases. Diagnosis was established by histological examination of a surgical wedge
M, De Vos, F, Barbier, C, Cuvelier
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Australasian Annals of Medicine, 1962
SUMMARYA family with a high incidence of hepatomegaly, normal liver function and stillbirths is described. In one member biopsy material confirmed the diagnosis of congenital hepatic fibrosis. This patient's sister probably died of the same disorder. Unusual hepatic sinusoidal prominence was present in the patient described and in one of her daughters,
J B, HICKIE, J M, GARVAN
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SUMMARYA family with a high incidence of hepatomegaly, normal liver function and stillbirths is described. In one member biopsy material confirmed the diagnosis of congenital hepatic fibrosis. This patient's sister probably died of the same disorder. Unusual hepatic sinusoidal prominence was present in the patient described and in one of her daughters,
J B, HICKIE, J M, GARVAN
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Key Players of Hepatic Fibrosis
Journal of Interferon and Cytokine Research, 2020Hepatic fibrosis is a complex mechanism defined by the net deposition of the extracellular matrix (ECM) owing to liver injury caused by multiple etiologies such as viral hepatitis and nonalcoholic fatty liver disease.
R. Dawood +3 more
semanticscholar +1 more source
Toxicology, 2008
The study of hepatic fibrosis, or scarring in response to chronic liver injury, has witnessed tremendous progress in the past two decades. Clarification of the cellular sources of scar, and emergence of hepatic stellate cells not only as a fibrogenic cell type, but also as a critical immunomodulatory and homeostatic regulator are among the most salient
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The study of hepatic fibrosis, or scarring in response to chronic liver injury, has witnessed tremendous progress in the past two decades. Clarification of the cellular sources of scar, and emergence of hepatic stellate cells not only as a fibrogenic cell type, but also as a critical immunomodulatory and homeostatic regulator are among the most salient
openaire +2 more sources
Hepatology, 2019
Bone morphogenetic protein 9 (BMP9) is a circulating factor produced by hepatic stellate cells that plays a critical role in vascular quiescence through its endothelial receptor activin receptor‐like kinase 1 (ALK1).
A. Desroches-Castan +10 more
semanticscholar +1 more source
Bone morphogenetic protein 9 (BMP9) is a circulating factor produced by hepatic stellate cells that plays a critical role in vascular quiescence through its endothelial receptor activin receptor‐like kinase 1 (ALK1).
A. Desroches-Castan +10 more
semanticscholar +1 more source
Archives of Surgery, 1965
CONGENITAL hepatic fibrosis is a rare cause of intrahepatic portal hypertension in children or young adults. Hepatic function is well preserved, as in extrahepatic obstruction, making these patients acceptable candidates for surgical decompression of their portal hypertension.
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CONGENITAL hepatic fibrosis is a rare cause of intrahepatic portal hypertension in children or young adults. Hepatic function is well preserved, as in extrahepatic obstruction, making these patients acceptable candidates for surgical decompression of their portal hypertension.
openaire +2 more sources