Results 1 to 10 of about 223,054 (350)
Hepatic Stellate Cell-Immune Interactions in NASH
Frontiers in Endocrinology, 2022 Nonalcoholic fatty liver disease (NAFLD) is the dominant cause of liver disease worldwide. Nonalcoholic steatohepatitis (NASH), a more aggressive presentation of NAFLD, is characterized by severe hepatocellular injury, inflammation, and fibrosis. Chronic
James K. Carter, S. L. Friedman
semanticscholar +4 more sources
Hepatic Stellate Cell Senescence in Liver Fibrosis: Characteristics, Mechanisms and Perspectives.
Mechanisms of Ageing and Development, 2021 Myofibroblasts play an important role in fibrogenesis. Hepatic stellate cells are the main precursors of myofibroblasts. Cellular senescence is the terminal cell fate in which proliferating cells undergo irreversible cell cycle arrest.
Mengfan Zhang +5 more
semanticscholar +3 more sources
β-arrestin1 activates hepatic stellate cells to promote liver fibrosis via activating p38 signaling pathway [PDF]
Xin yixue, 2023 Objective To investigate the role ofβ-arrestin1 （ARRB1） in liver fibrosis and elucidate the mechanism of hepatic stellate cell activation induced by ARRB1/p38 signaling pathway to promote liver fibrosis.
Xia Yanhao, Liu Huiling, Jiang Jie, Wu Bin
doaj +1 more source
Hepatic-stellate-cell-targeted delivery of PU.1 decoy ODN by Apt-Tan attenuates liver fibrosis in mice [PDF]
Molecular Therapy: Nucleic AcidsTargeted therapeutics for liver fibrosis (LF) are unavailable. PU.1 is a pioneer transcription factor (TF) that promotes hepatic stellate cell (HSC) activation and LF.
Yong Tan +11 more
doaj +2 more sources
Cell Metabolism, 2023 Lactate was implicated in the activation of hepatic stellate cells (HSCs). However, the mechanism by which lactate exerts its effect remains elusive. Using RNA-seq and CUT&Tag chromatin profiling, we found that induction of hexokinase 2 (HK2) expression ...
H. Rho +3 more
semanticscholar +1 more source
Role of cytoglobin, a novel radical scavenger, in stellate cell activation and hepatic fibrosis [PDF]
Clinical and Molecular Hepatology, 2020 Cytoglobin (Cygb), a stellate cell-specific globin, has recently drawn attention due to its association with liver fibrosis. In the livers of both humans and rodents, Cygb is expressed only in stellate cells and can be utilized as a marker to distinguish
Le Thi Thanh Thuy +2 more
doaj +1 more source
Nature Metabolism, 2022 Extracellular vesicles play crucial roles in intercellular communication in the tumor microenvironment. Here we demonstrate that in hepatic fibrosis, TGF-β stimulates the palmitoylation of hexokinase 1 (HK1) in hepatic stellate cells (HSCs), which ...
Qi-Tao Chen +15 more
semanticscholar +1 more source
Single-cell RNA sequencing of human liver reveals hepatic stellate cell heterogeneity
JHEP Reports, 2021 Background & Aims The multiple vital functions of the human liver are performed by highly specialised parenchymal and non-parenchymal cells organised in complex collaborative sinusoidal units. Although crucial for homeostasis, the cellular make-up of the
V. Payen +10 more
semanticscholar +1 more source
Cell Proliferation, 2021 Evidences demonstrate that sorafenib alleviates liver fibrosis via inhibiting HSC activation and ECM accumulation. The underlying mechanism remains unclear.
Siyu Yuan +7 more
semanticscholar +1 more source
Hepatic Stellate Cells and Hepatocarcinogenesis [PDF]
Frontiers in Cell and Developmental Biology, 2020 Hepatic stellate cells (HSCs) are a significant component of the hepatocellular carcinoma (HCC) tumor microenvironment (TME). Activated HSCs transform into myofibroblast-like cells to promote fibrosis in response to liver injury or chronic inflammation, leading to cirrhosis and HCC.
Anna E. Barry +12 more
openaire +3 more sources