Results 21 to 30 of about 41,822 (262)
BMC Cell Biology, 2000 Background The hepatic stellate cell is the primary cell type responsible for the excessive formation and deposition of connective tissue elements during the development of hepatic fibrosis in chronically injured liver.
Kunz Dagmar +5 more
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Genetic Characterization of Rat Hepatic Stellate Cell Line PAV-1
Cells, 2023 The rat hepatic stellate cell line PAV-1 was established two decades ago and proposed as a cellular model to study aspects of hepatic retinoic acid metabolism.
Kiara Gäberlein +9 more
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PPAR Gamma and Hepatic Stellate Cells [PDF]
Comparative Hepatology, 2004 Activation of Hepatic stellate cells (HSC) in fibrogenesis involves distinct morphological and biochemical changes. This activation requires the coordinated changes in activity of several transcription factors. Peroxisome proliferator-activated receptor gamma (PPAR gamma) is one such factor whose activity is decreased in activated HSC.
Hazra, Saswati +3 more
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Parasites & Vectors, 2019 Background Activation of hepatic stellate cells is the dominant pathogenic event during the process of liver fibrosis. Bone morphogenic protein (BMP)-7 has recently been identified as an anti-fibrotic factor and leads to phosphorylation of Smad1/5/8 in ...
Liuting Chen +7 more
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The roles of microRNA families in hepatic fibrosis
Cell & Bioscience, 2017 When hepatocytes are damaged severely, a variety of signaling pathways will be triggered by inflammatory factors and cytokines involving in the process of hepatic fibrosis.
Xue-Ping Jiang +4 more
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Livers, 2023 Hepatic stellate cells (HSCs) are a liver-specific mesenchymal cell type located in the Dissé space between hepatocytes and sinusoidal endothelial cells [...]
Ralf Weiskirchen, Scott L. Friedman
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The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli +3 more
wiley +1 more source
Frontiers in Endocrinology, 2022 Fatty liver disease is a spectrum of liver pathologies ranging from simple hepatic steatosis to non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), and culminating with the development of cirrhosis or hepatocellular carcinoma
Bing Yang +7 more
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Fibrogenic signalling in hepatic stellate cells
Journal of Hepatology, 2010 (1) Upon liver damage, hepatic stellate cells undergo a process defined as activation (Fig. 1), that enables them to acquire a myofibroblastic phenotype. The biological actions of myofibroblasts are pivotal for liver tissue repair and fibrogenesis [1]. (2) Activation of TGFb-dependent fibrogenic signalling in hepatic stellate cells.
D.A. Mann, MARRA, FABIO
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Liver cirrhosis and hepatic stellate cells [PDF]
Acta Cirurgica Brasileira, 2006 The cirrhosis represents the final stage of several chronic hepatic diseases and it is characterized by the presence of fibrosis and morphologic conversion from the normal hepatic architecture into structurally abnormal nodules. In the evolution of the disease there is loss of the normal vascular relationship and portal hypertension.
Brandão, Daniel Ferracioli +5 more
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