Results 11 to 20 of about 43,780 (265)
Hepatic Stellate Cells and Hepatocarcinogenesis [PDF]
Frontiers in Cell and Developmental Biology, 2020 Hepatic stellate cells (HSCs) are a significant component of the hepatocellular carcinoma (HCC) tumor microenvironment (TME). Activated HSCs transform into myofibroblast-like cells to promote fibrosis in response to liver injury or chronic inflammation, leading to cirrhosis and HCC.
Anna E. Barry +12 more
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NOX as a Therapeutic Target in Liver Disease
Antioxidants, 2022 The nicotinamide adenine dinucleotide phosphate hydrogen oxidase (NADPH oxidase or NOX) plays a critical role in the inflammatory response and fibrosis in several organs such as the lungs, pancreas, kidney, liver, and heart. In the liver, NOXs contribute,
Deyamira Matuz-Mares +2 more
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Hepatic Stellate Cells: Dictating Outcome in Nonalcoholic Fatty Liver DiseaseSummary
Cellular and Molecular Gastroenterology and Hepatology, 2023 Nonalcoholic fatty liver disease (NAFLD) is a fast growing, chronic liver disease affecting ∼25% of the global population. Nonalcoholic fatty liver disease severity ranges from the less severe simple hepatic steatosis to the more advanced nonalcoholic ...
Leke Wiering +2 more
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Hepatic stellate cell progenitor cells [PDF]
Journal of Gastroenterology and Hepatology, 2012 AbstractHepatic stellate cells (HSCs) are recognized as a major player in liver fibrogenesis. Upon liver injury, HSCs differentiate into myofibroblasts and participate in progression of fibrosis and cirrhosis. Additional cell types such as resident liver fibroblasts/myofibroblasts or bone marrow cells are also known to generate myofibroblasts.
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FEBS Open Bio, 2022 Elevated interstitial fluid hydrostatic pressure is commonly observed in diseased livers. We herein examined the hypothesis that hydrostatic pressure induces hepatic stellate cells to acquire profibrotic properties under pathological conditions.
Zisheng Huang +3 more
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Overexpression of endoglin modulates TGF-β1-signalling pathways in a novel immortalized mouse hepatic stellate cell line. [PDF]
PLoS ONE, 2013 Hepatic stellate cells (HSCs) play a major role in the pathogenesis of liver fibrosis. Working on primary HSCs requires difficult isolation procedures; therefore we have generated and here characterize a mouse hepatic stellate cell line expressing GFP ...
Steffen K Meurer +8 more
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Frontiers in Cell and Developmental Biology, 2021 Hepatic fibrosis is the final pathway of several chronic liver diseases, which is characterized by the accumulation of extracellular matrix due to chronic hepatocyte damage. Activation of hepatic stellate cells and oxidative stress (OS) play an important
Wenzhang Dai +17 more
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ADAMTS13 is expressed in hepatic stellate cells [PDF]
Laboratory Investigation, 2005 ADAMTS13 is a circulating zinc metalloprotease that cleaves the hemostatic glycoprotein von Willebrand factor (VWF) in a shear-dependent manner. Deficiency in ADAMTS13, owing to genetic mutations or autoimmune inhibitors, causes thrombotic thrombocytopenic purpura (TPP). Northern blot analysis has shown that ADAMTS13 is expressed primarily in the liver.
Wenhua, Zhou +7 more
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Hepatic stellate cells and parasite-induced liver fibrosis
Parasites & Vectors, 2010 Fibrogenesis is a common feature of many diseases where there is severe insult to the liver. The hepatic stellate cell trans-differentiation into a myofibroblast has been identified as an important event in liver fibrogenesis and has been well ...
Li Yuesheng S +3 more
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Toll-Like Receptor Signaling and Liver Fibrosis
Gastroenterology Research and Practice, 2010 Liver fibrosis occurs as a wound-healing scar response following acute and chronic liver inflammation including alcoholic liver disease, non-alcoholic steatohepatitis, hepatitis B and C, and autoimmune hepatitis.
Tomonori Aoyama +2 more
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