Results 11 to 20 of about 223,054 (350)

Acetyl-CoA carboxylase inhibition disrupts metabolic reprogramming during hepatic stellate cell activation.

Journal of Hepatology, 2020
BACKGROUND & AIMS Nonalcoholic steatohepatitis (NASH) is a chronic liver disease characterized by hepatic lipid accumulation, inflammation, and progressive fibrosis. Acetyl-CoA carboxylase (ACC) catalyzes the rate-limiting step of de novo lipogenesis and
J. Bates, A. Vijayakumar, Sarani Ghoshal, B. Marchand, Saili Yi, D. Kornyeyev, A. Zagórska, D. Hollenback, Katie Walker, Kathy Liu, Swetha Pendem, D. Newstrom, R. Brockett, I. Mikaelian, Saritha Kusam, Ricardo Ramírez, David Lopez, Li Li, B. Fuchs, D. Breckenridge   +19 more
semanticscholar   +3 more sources

Hepatic stellate cell autophagy inhibits extracellular vesicle release to attenuate liver fibrosis.

Journal of Hepatology, 2020
BACKGROUND AND AIM In chronic liver injury, platelet-derived growth factor (PDGF)-stimulated hepatic stellate cells (HSCs) release fibrogenic extracellular vesicles (EVs).
Jinhang Gao, Bo Wei, T. D. De Assuncao, Zhikui Liu, Xiao Hu, Samar H. Ibrahim, Shawna A. Cooper, Sheng Cao, V. Shah, Enis Kostallari   +9 more
semanticscholar   +3 more sources

Thrombin and factor Xa link the coagulation system with liver fibrosis

BMC Gastroenterology, 2018
Background Thrombin activates hepatic stellate cells via protease-activated receptor-1. The role of Factor Xa (FXa) in hepatic fibrosis has not been elucidated.
Ameet Dhar, Fouzia Sadiq, Quentin M. Anstee, Adam P. Levene, Robert D. Goldin, Mark R. Thursz   +5 more
doaj   +2 more sources

Comparative evaluation of gene delivery devices in primary cultures of rat hepatic stellate cells and rat myofibroblasts [PDF]

BMC Cell Biology, 2000
Background The hepatic stellate cell is the primary cell type responsible for the excessive formation and deposition of connective tissue elements during the development of hepatic fibrosis in chronically injured liver.
Kunz Dagmar, van de Leur Eddy, Weiskirchen Sabine, Kneifel Jens, Weiskirchen Ralf, Gressner Axel M   +5 more
doaj   +3 more sources

Opposing roles of hepatic stellate cell subpopulations in hepatocarcinogenesis

Nature, 2022
A. Filliol, Yoshinobu Saito, A. Nair, D. Dapito, Le-xing Yu, Aashreya Ravichandra, S. Bhattacharjee, S. Affò, N. Fujiwara, H. Su, Qiuyan Sun, Thomas M. Savage, J. Wilson-Kanamori, J. Caviglia, Likang Chin, Dongning Chen, Xiaobo Wang, S. Caruso, J. Kang, A. D. Amin, Sebastian Wallace, R. Dobie, Deqi Yin, Oscar M Rodriguez-Fiallos, C. Yin, Adam Mehal, Benjamin Izar, R. Friedman, R. Wells, U. Pajvani, Y. Hoshida, H. Remotti, Nicholas Arpaia, J. Zucman‐Rossi, M. Karin, N. Henderson, I. Tabas, R. Schwabe   +37 more
semanticscholar   +3 more sources

Extra- and Intra-Cellular Mechanisms of Hepatic Stellate Cell Activation

Biomedicines, 2021
Hepatic fibrosis is characterized by the pathological accumulation of extracellular matrix (ECM) in the liver resulting from the persistent liver injury and wound-healing reaction induced by various insults.
Yu-Xin Yan, Jiefei Zeng, Linhao Xing, Changyong Li   +3 more
semanticscholar   +1 more source

The C-type lectin COLEC10 is predominantly produced by hepatic stellate cells and involved in the pathogenesis of liver fibrosis

Cell Death and Disease, 2023
Hepatic stellate cell is one of the major nonparenchymal cell types in liver. It has been proved the hepatic stellate cells are activated upon liver injury and produce excessive extracellular matrix to induce liver fibrosis.
Mengfan Zhang, Yang Jing, Wenze Xu, Xiaojing Shi, Wenguang Zhang, Pengfei Chen, Xiaocang Cao, Xinwei Han, Xuhua Duan, Jianzhuang Ren   +9 more
doaj   +1 more source

Initiation of hepatic stellate cell activation extends into chronic liver disease

Cell Death and Disease, 2021
Activated hepatic stellate cells (aHSC) are the main source of extra cellular matrix in liver fibrosis. Activation is classically divided in two phases: initiation and perpetuation.
Vincent De Smet, N. Eysackers, Vincent Merens, Mina Kazemzadeh Dastjerd, G. Halder, S. Verhulst, I. Mannaerts, L. V. van Grunsven   +7 more
semanticscholar   +1 more source

GATA4 induces liver fibrosis regression by deactivating hepatic stellate cells

JCI Insight, 2021
In response to liver injury, hepatic stellate cells activate and acquire proliferative and contractile features. The regression of liver fibrosis appears to involve the clearance of activated hepatic stellate cells, either by apoptosis or by reversion ...
Noelia Arroyo, Laura Villamayor, Irene Díaz, Rita Carmona, Mireia Ramos-Rodríguez, Ramón Muñoz-Chápuli, Lorenzo Pasquali, Miguel G. Toscano, Franz Martín, David A. Cano, Anabel Rojas   +10 more
doaj   +1 more source

Replacement of retinyl esters by polyunsaturated triacylglycerol species in lipid droplets of hepatic stellate cells during activation. [PDF]

PLoS ONE, 2012
Activation of hepatic stellate cells has been recognized as one of the first steps in liver injury and repair. During activation, hepatic stellate cells transform into myofibroblasts with concomitant loss of their lipid droplets (LDs) and production of ...
Nicole Testerink, Mokrish Ajat, Martin Houweling, Jos F Brouwers, Vishnu V Pully, Henk-Jan van Manen, Cees Otto, J Bernd Helms, Arie B Vaandrager   +8 more
doaj   +1 more source