Results 31 to 40 of about 223,054 (350)
Hepatic Stellate Cells Support Hematopoiesis and are Liver-Resident Mesenchymal Stem Cells
Cellular Physiology and Biochemistry, 2013 Background/Aims: Hematopoiesis can occur in the liver, when the bone marrow fails to provide an adequate environment for hematopoietic stem cells.
Claus Kordes +3 more
doaj +1 more source
FEBS Open Bio, 2022 Elevated interstitial fluid hydrostatic pressure is commonly observed in diseased livers. We herein examined the hypothesis that hydrostatic pressure induces hepatic stellate cells to acquire profibrotic properties under pathological conditions.
Zisheng Huang +3 more
doaj +1 more source
TGF-β in Hepatic Stellate Cell Activation and Liver Fibrogenesis—Updated 2019
Cells, 2019 Liver fibrosis is an advanced liver disease condition, which could progress to cirrhosis and hepatocellular carcinoma. To date, there is no direct approved antifibrotic therapy, and current treatment is mainly the removal of the causative factor ...
B. Dewidar +3 more
semanticscholar +1 more source
Frontiers in Cell and Developmental Biology, 2021 Hepatic fibrosis is the final pathway of several chronic liver diseases, which is characterized by the accumulation of extracellular matrix due to chronic hepatocyte damage. Activation of hepatic stellate cells and oxidative stress (OS) play an important
Wenzhang Dai +17 more
doaj +1 more source
Nature Cell Biology, 2020 The crosstalk between deregulated hepatocyte metabolism and cells within the tumour microenvironment, as well as the consequent effects on liver tumorigenesis, are not completely understood. We show here that hepatocyte-specific loss of the gluconeogenic
Fuming Li +16 more
semanticscholar +1 more source
Overexpression of endoglin modulates TGF-β1-signalling pathways in a novel immortalized mouse hepatic stellate cell line. [PDF]
PLoS ONE, 2013 Hepatic stellate cells (HSCs) play a major role in the pathogenesis of liver fibrosis. Working on primary HSCs requires difficult isolation procedures; therefore we have generated and here characterize a mouse hepatic stellate cell line expressing GFP ...
Steffen K Meurer +8 more
doaj +1 more source
Hepatic Stellate Cell–Macrophage Crosstalk in Liver Fibrosis and Carcinogenesis
Seminars in liver disease (Print), 2020 Chronic liver injury due to viral hepatitis, alcohol abuse, and metabolic disorders is a worldwide health concern. Insufficient treatment of chronic liver injury leads to fibrosis, causing liver dysfunction and carcinogenesis.
M. Matsuda, E. Seki
semanticscholar +1 more source
Matrix metalloproteinases in liver injury, repair and fibrosis. [PDF]
, 2015 The liver is a large highly vascularized organ with a central function in metabolic homeostasis, detoxification, and immunity. Due to its roles, the liver is frequently exposed to various insults which can cause cell death and hepatic dysfunction ...
Baber, John +3 more
core +1 more source
Critical Role of microRNA-21 in the Pathogenesis of Liver Diseases [PDF]
, 2020 MicroRNAs are small non-coding RNAs that range in length from 18 to 24 nucleotides. As one of the most extensively studied microRNAs, microRNA-21 (miR-21) is highly expressed in many mammalian cell types.
Han, Sen +4 more
core +1 more source
Hepatic stellate cells and parasite-induced liver fibrosis
Parasites & Vectors, 2010 Fibrogenesis is a common feature of many diseases where there is severe insult to the liver. The hepatic stellate cell trans-differentiation into a myofibroblast has been identified as an important event in liver fibrogenesis and has been well ...
Li Yuesheng S +3 more
doaj +1 more source