Results 51 to 60 of about 223,054 (350)

rSjp40 inhibits activated hepatic stellate cells by promoting nuclear translocation of YB1 and inducing BMP-7/Smad1/5/8 pathway

Parasites & Vectors, 2019
Background Activation of hepatic stellate cells is the dominant pathogenic event during the process of liver fibrosis. Bone morphogenic protein (BMP)-7 has recently been identified as an anti-fibrotic factor and leads to phosphorylation of Smad1/5/8 in ...
Liuting Chen, Qi Zhou, Ertao Liu, Jiali Zhang, Lian Duan, Dandan Zhu, Jinling Chen, Yinong Duan   +7 more
doaj   +1 more source

Liver cirrhosis and hepatic stellate cells [PDF]

Acta Cirurgica Brasileira, 2006
The cirrhosis represents the final stage of several chronic hepatic diseases and it is characterized by the presence of fibrosis and morphologic conversion from the normal hepatic architecture into structurally abnormal nodules. In the evolution of the disease there is loss of the normal vascular relationship and portal hypertension.
Brandão, Daniel Ferracioli, Ramalho, Leandra Naira Zambelli, Ramalho, Fernando Silva, Zucoloto, Sérgio, Martinelli, Ana de Lourdes Candolo, Castro e Silva, Orlando de   +5 more
openaire   +4 more sources

Molecular mechanisms controlling the phenotype and the EMT/MET dynamics of hepatocyte [PDF]

, 2014
The complex spatial and paracrine relationships between the various liver histotypes are essential for proper functioning of the hepatic parenchymal cells.
Fausto N, Lazarevich NL, Michelotti GA, Omenetti A, Spagnoli FM, Treyer A, Valdes F   +6 more
core   +3 more sources

The roles of microRNA families in hepatic fibrosis

Cell & Bioscience, 2017
When hepatocytes are damaged severely, a variety of signaling pathways will be triggered by inflammatory factors and cytokines involving in the process of hepatic fibrosis.
Xue-Ping Jiang, Wen-Bing Ai, Lin-Yan Wan, Yan-Qiong Zhang, Jiang-Feng Wu   +4 more
doaj   +1 more source

Human Liver Stem Cell-Derived Extracellular Vesicles Target Hepatic Stellate Cells and Attenuate Their Pro-fibrotic Phenotype

Frontiers in Cell and Developmental Biology, 2021
Liver fibrosis occurs in response to chronic liver injury and is characterized by an excessive deposition of extracellular matrix. Activated hepatic stellate cells are primarily responsible for this process.
Giulia Chiabotto, Elena Ceccotti, Marta Tapparo, G. Camussi, S. Bruno   +4 more
semanticscholar   +1 more source

The role of human cytochrome P450 2E1 in liver inflammation and fibrosis. [PDF]

, 2017
Cytochrome P450 2E1 (CYP2E1) plays an important role in alcohol and toxin metabolism by catalyzing the conversion of substrates into more polar metabolites and producing reactive oxygen species.
Brenner, David A, Davidson, Nicholas O, Dennis, Edward A, Hu, Ronglin, Karin, Gabriel, Kisseleva, Tatiana, Koyama, Yukinori, Liang, Shuang, Ma, Hsiao-Yen, Quehenberger, Oswald, Sun, Mengxi, Xu, Jun   +11 more
core   +1 more source

Cholangiocyte‐Derived Exosomal Long Noncoding RNA H19 Promotes Hepatic Stellate Cell Activation and Cholestatic Liver Fibrosis

Hepatology, 2019
Activation of hepatic stellate cells (HSCs) represents the primary driving force to promote the progression of chronic cholestatic liver diseases. We previously reported that cholangiocyte‐derived exosomal long noncoding RNA‐H19 (lncRNA‐H19) plays a ...
Runping Liu, Xiaojiaoyang Li, Weiwei Zhu, Weiwei Zhu, Yanyan Wang, Yanyan Wang, Derrick Zhao, Xuan Wang, E. Gurley, G. Liang, Weidong Chen, Guanhua Lai, W. Pandak, H. Lippman, J. Bajaj, P. Hylemon, Huiping Zhou   +16 more
semanticscholar   +1 more source

Intestinal fungi contribute to development of alcoholic liver disease [PDF]

, 2017
This study was supported in part by NIH grants R01 AA020703, U01 AA021856 and by Award Number I01BX002213 from the Biomedical Laboratory Research & Development Service of the VA Office of Research and Development (to B.S.). K.H.
Ali Keshavarzian, An-Ming Yang, Bernd Schnabl, Bode, Chien-Sheng Chen, Claus Hellerbrand, Cristina Llorente, Derrick E. Fouts, Ece A. Mutlu, Fettweis, Fouts, Gordon D. Brown, Guadalupe Garcia-Tsao, Hal M. Hoffman, Jun Xu, Karen Beeri, Katrin Hochrath, Kelvin Moncera, Kim Freese, Lee, Lirui Wang, Liu, Manolito G. Torralba, Peng Chen, Peter Stärkel, Phillipp Hartmann, Ramon Bataller, Samuel B. Ho, Sena Bluemel, Serene M.L. Lee, Sokol, Tatiana Kisseleva, Tatsuo Inamine, Wagner, Wajahat Z. Mehal, Yamahiro, Yang, Yukinori Koyama   +37 more
core   +3 more sources

PPAR Gamma and Hepatic Stellate Cells [PDF]

Comparative Hepatology, 2004
Activation of Hepatic stellate cells (HSC) in fibrogenesis involves distinct morphological and biochemical changes. This activation requires the coordinated changes in activity of several transcription factors. Peroxisome proliferator-activated receptor gamma (PPAR gamma) is one such factor whose activity is decreased in activated HSC.
Hazra, Saswati, Miyahara, Takeo, Rippe, Richard A, Tsukamoto, Hidekazu   +3 more
openaire   +2 more sources

CD4+T cells and natural killer cells: Biomarkers for hepatic fibrosis in human immunodeficiency virus/hepatitis C viruscoinfected patients [PDF]

, 2017
To characterize peripheral blood natural killer (NK) cells phenotypes by flow cytometry as potential biomarker of liver fibrosis in human immunodeficiency virus (HIV)/hepatitis C virus (HCV) coinfected patients.
Cahn, Pedro, Laufer, Natalia Lorna, Martinez, Ana, Ojeda, Diego Sebastian, Polo, Maria Laura, Pérez, Héctor, Quarleri, Jorge Fabian, Turk, Gabriela Julia Ana, Zwirner, Norberto Walter   +8 more
core   +1 more source