Results 61 to 70 of about 223,054 (350)
Livers, 2023 Hepatic stellate cells (HSCs) are a liver-specific mesenchymal cell type located in the Dissé space between hepatocytes and sinusoidal endothelial cells [...]
Ralf Weiskirchen, Scott L. Friedman
doaj +1 more source
Role of PINCH and Its Partner Tumor Suppressor Rsu-1 in Regulating Liver Size and Tumorigenesis [PDF]
, 2013 Particularly interesting new cysteine-histidine-rich protein (PINCH) protein is part of the ternary complex known as the IPP (integrin linked kinase (ILK)-PINCH-Parvin-α) complex.
Bhave, Vishakha S. +8 more
core +2 more sources
Frontiers in Endocrinology, 2022 Fatty liver disease is a spectrum of liver pathologies ranging from simple hepatic steatosis to non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), and culminating with the development of cirrhosis or hepatocellular carcinoma
Bing Yang +7 more
doaj +1 more source
Transcriptional regulation of Hepatic Stellate Cell activation in NASH
Scientific Reports, 2019 Non-alcoholic steatohepatitis (NASH) signified by hepatic steatosis, inflammation, hepatocellular injury, and fibrosis is a growing cause of chronic liver disease, cirrhosis, and hepatocellular carcinoma.
Ann-Britt Marcher +9 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Unfolded protein response is an early, non-critical event during hepatic stellate cell activation
Cell Death and Disease, 2019 Hepatic stellate cells activate upon liver injury and help at restoring damaged tissue by producing extracellular matrix proteins. A drastic increase in matrix proteins results in liver fibrosis and we hypothesize that this sudden increase leads to ...
I. Mannaerts +8 more
semanticscholar +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer
Aging and Cancer, EarlyView.Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss +12 more
wiley +1 more source
Drug Design, Development and Therapy, 2018 Purpose Liver fibrosis is a worldwide health issue. Development of effective new drugs for treatment of this disease is of great importance. This study investigated the therapeutic effects of ferulic acid on liver fibrosis in vitro and in vivo. Materials
M. Mu +9 more
semanticscholar +1 more source
Fibrogenic signalling in hepatic stellate cells
Journal of Hepatology, 2010 (1) Upon liver damage, hepatic stellate cells undergo a process defined as activation (Fig. 1), that enables them to acquire a myofibroblastic phenotype. The biological actions of myofibroblasts are pivotal for liver tissue repair and fibrogenesis [1]. (2) Activation of TGFb-dependent fibrogenic signalling in hepatic stellate cells.
D.A. Mann, MARRA, FABIO
openaire +4 more sources