Results 351 to 360 of about 1,196,134 (401)
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Targeting Hepatic Fibrosis in Autoimmune Hepatitis
Digestive Diseases and Sciences, 2016Hepatic fibrosis develops or progresses in 25 % of patients with autoimmune hepatitis despite corticosteroid therapy. Current management regimens lack reliable noninvasive methods to assess changes in hepatic fibrosis and interventions that disrupt fibrotic pathways.
Aldo J, Montano-Loza +2 more
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Seminars in Liver Disease, 1990
Although there is no established therapy for the fibrogenesis of hepatic cirrhosis, many potential therapies are now emerging. The requirements for the "perfect therapy" for hepatic fibrosis can be listed: (1) the pharmacologic agent should be active only in the liver; (2) its effect should be specific for collagen (or another critical extracellular ...
D A, Brenner, J M, Alcorn
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Although there is no established therapy for the fibrogenesis of hepatic cirrhosis, many potential therapies are now emerging. The requirements for the "perfect therapy" for hepatic fibrosis can be listed: (1) the pharmacologic agent should be active only in the liver; (2) its effect should be specific for collagen (or another critical extracellular ...
D A, Brenner, J M, Alcorn
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Deferiprone and hepatic fibrosis
Blood, 2003We write to request that Wanless and colleagues correct the record on the efficacy and safety of deferiprone for treatment of transfusional iron overload by providing the data on hepatic iron omitted from their publication in Blood.
Gary M, Brittenham +6 more
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Journal of Cellular Physiology, 2019
This study is conducted to investigate the role of long noncoding RNA highly upregulated in liver cancer (lncRNA HULC) on hepatic fibrosis and hepatocyte apoptosis by inhibiting the mitogen‐activated protein kinase (MAPK) signaling pathway in rats with ...
Xingtong Shen +3 more
semanticscholar +1 more source
This study is conducted to investigate the role of long noncoding RNA highly upregulated in liver cancer (lncRNA HULC) on hepatic fibrosis and hepatocyte apoptosis by inhibiting the mitogen‐activated protein kinase (MAPK) signaling pathway in rats with ...
Xingtong Shen +3 more
semanticscholar +1 more source
Consensus on the diagnosis and treatment of hepatic fibrosis (2019)
Journal of Digestive Diseases, 2020Hepatic fibrosis is a reparative response of diffuse over‐deposition and abnormal distribution of extracellular matrix (collagen, glycoprotein and proteoglycans) after exposure to various kinds of liver injuries, and is a key step in the developmental ...
Lungen Lu, H. You, W. Xie, J. Jia
semanticscholar +1 more source
Current Gastroenterology Reports, 2018
The purpose of this review is to discuss the current imaging techniques for non-invasive assessment of liver fibrosis (LF).Elastography-based techniques are the most widely used imaging methods for the evaluation of LF. Currently, MR elastography (MRE) is the most accurate non-invasive method for detection and staging of LF.
Rishi Philip, Mathew +1 more
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The purpose of this review is to discuss the current imaging techniques for non-invasive assessment of liver fibrosis (LF).Elastography-based techniques are the most widely used imaging methods for the evaluation of LF. Currently, MR elastography (MRE) is the most accurate non-invasive method for detection and staging of LF.
Rishi Philip, Mathew +1 more
openaire +2 more sources
Medicina Clínica (English Edition), 2018
Chronic liver diseases constitute a major health problem. Chronic liver inflammation, defined by the degree of hepatic fibrosis, is asymptomatic in a significant percentage of patients; hence, the disease often remains undiagnosed until it has reached very advanced phases and, frequently, when the damage is irreversible.
Llorenç, Caballería +2 more
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Chronic liver diseases constitute a major health problem. Chronic liver inflammation, defined by the degree of hepatic fibrosis, is asymptomatic in a significant percentage of patients; hence, the disease often remains undiagnosed until it has reached very advanced phases and, frequently, when the damage is irreversible.
Llorenç, Caballería +2 more
openaire +2 more sources
Isoprostanes and hepatic fibrosis
Molecular Aspects of Medicine, 2008After a brief introduction to oxidative stress, the discovery of F(2)-isoprostanes as specific and reliable markers of oxidative stress is described. Isoprostanes are also agonists of important biological effects. Since a relation between oxidative stress and collagen hyperproduction has been previously suggested and since lipid peroxidation products ...
COMPORTI, M. +5 more
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The American Journal of Digestive Diseases, 1974
Congenital hepatic fibrosis (CHF) was detected in a 10-year-old boy with hepatosplenomegaly and leukopenia and in a 45-year-old man with hepatomegaly. Several years after these original findings, both patients developed bleeding that was attributed to esophageal varices and were treated by elective portasystemic shunts.
H A, Campana, Y S, Park, G D, Gourgoutis
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Congenital hepatic fibrosis (CHF) was detected in a 10-year-old boy with hepatosplenomegaly and leukopenia and in a 45-year-old man with hepatomegaly. Several years after these original findings, both patients developed bleeding that was attributed to esophageal varices and were treated by elective portasystemic shunts.
H A, Campana, Y S, Park, G D, Gourgoutis
openaire +2 more sources
Journal of Pediatric Gastroenterology and Nutrition, 1984
One family with four of seven siblings with congenital hepatic fibrosis. is reported. The proband, the only member of this family with symptoms referable to the disease, was hospitalized because of an upper gastrointestinal hemorrhage. He had a presinusoidal type of portal hypertension. The other three siblings had the latent form of congenital hepatic
J, Pereira-Lima +3 more
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One family with four of seven siblings with congenital hepatic fibrosis. is reported. The proband, the only member of this family with symptoms referable to the disease, was hospitalized because of an upper gastrointestinal hemorrhage. He had a presinusoidal type of portal hypertension. The other three siblings had the latent form of congenital hepatic
J, Pereira-Lima +3 more
openaire +2 more sources