Results 291 to 300 of about 223,054 (350)

Tanshinone IIA attenuates hepatic stellate cell activation, oxidative stress, and liver fibrosis by inhibiting YAP signaling. [PDF]

Eur J Histochem
Wang D, Tan Q, Zheng Q, Ma Y, Feng L.
europepmc   +1 more source

Gene network activity in cultivated primary hepatocytes is highly similar to diseased mammalian liver tissue [PDF]

, 2016
et al,, Meganathan, Kesavan
core   +1 more source

Cellular crosstalk mediated by Meteorin-like regulating hepatic stellate cell activation during hepatic fibrosis. [PDF]

Cell Death Dis
Zhou Y, Wang G, Liu L, Song L, Hu L, Liu L, Xu L, Wang T, Liu L, Wang Y, Zhang T, Guo B.   +11 more
europepmc   +1 more source

Integrated stress response-mediated metabolic reprogramming drives hepatic stellate cell activation and liver fibrosis via the noncanonical EIF3d-ATF4-S100P signaling pathway. [PDF]

Redox Biol
Yang S, Zhang H, Sun X, Chen Z, Nie Z, Li Y, Liu X, Kong Y, Wang Z, Zai W, Gao S, Chen W.   +11 more
europepmc   +1 more source

Amelioration of Liver Fibrosis via In Situ Hepatic Stellate Cell Conversion Through Co-Inhibition of TGF-β and GSK-3 Signalling. [PDF]

Liver Int
Zhu XJ, Zhong Z, Du JC, Zhang JY, Zhang X, Cui XL, Guan LT, Hu YY, Chen C, Wang H, Wu XY, Zhang WJ, Zhang PL, Wang HY.   +13 more
europepmc   +1 more source

Chikusetsusaponin IVa targeted YAP as an inhibitor to attenuate liver fibrosis and hepatic stellate cell activation. [PDF]

Chin Med
Gao K, Zhang W, Xu D, Zhao M, Tao X, Lu Y, Wang J.   +6 more
europepmc   +1 more source

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Mechanisms of hepatic stellate cell activation

Nature Reviews Gastroenterology & Hepatology, 2017
Hepatic fibrosis is a dynamic process characterized by the net accumulation of extracellular matrix resulting from chronic liver injury of any aetiology, including viral infection, alcoholic liver disease and NASH. Activation of hepatic stellate cells (HSCs) - transdifferentiation of quiescent, vitamin-A-storing cells into proliferative, fibrogenic ...
Takuma Tsuchida, S. Friedman
semanticscholar   +5 more sources

Transcriptional regulation of hepatic stellate cells

Advanced Drug Delivery Reviews, 2009
Hepatic stellate cell (HSC) activation is a process of cellular transdifferentiation in which, upon liver injury, the quiescent vitamin A storing perisinusoidal HSC is converted into a wound-healing myofibroblast and acquires potent pro-inflammatory and pro-fibrogenic activities.
Mann J, Mann DA
openaire   +5 more sources

Studying Hepatic Stellate Cell Senescence

2023
Hepatic stellate cells (HSCs) are the key effector cells in liver fibrosis. They are the main producers of excessive amounts of extracellular matrix components during fibrogenesis and therefore a potential target for the treatment of liver fibrosis.
Sandra A, Serna-Salas, Abel A, Soto-Gámez, Zongmei, Wu, Myrthe, Klaver, Han, Moshage   +4 more
openaire   +3 more sources

MicroRNA interplay between hepatic stellate cell quiescence and activation.

European Journal of Pharmacology, 2020
Hepatic stellate cells (HSCs) activation play a significant role in the progression of hepatic fibrosis. During chronic liver diseases, hepatocytes are damaged severely and secrete several pro-inflammatory markers and profibrogenic cytokines via ...
D. Ezhilarasan
semanticscholar   +1 more source