Results 301 to 310 of about 223,054 (350)
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Phytomedicine, 2020
BACKGROUND Hepatic fibrosis is considered integral to the progression of chronic liver diseases, as it leads to the development of cirrhosis and hepatocellular carcinoma.
Dejuan Xiang +6 more
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BACKGROUND Hepatic fibrosis is considered integral to the progression of chronic liver diseases, as it leads to the development of cirrhosis and hepatocellular carcinoma.
Dejuan Xiang +6 more
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Cryopreservation of hepatic stellate cells
Journal of Hepatology, 2006Isolated rat hepatic stellate cells (HSC) are taken as a valuable in vitro model to study hepatic fibrogenesis, biotransformation of pharmaceutics, gene expression, transcription factors controlling HSC behaviour, and for the establishment of long-term cultures. Consequently, methods for the isolation and maintenance of HSC cultures are well documented.
Svenja, Neyzen +6 more
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Chemico-Biological Interactions, 2019
Liver fibrosis is a pathological wound-healing response caused by chronic liver damage due to a virus, autoimmune disorder, or drugs. Hepatic stellate cells (HSCs) play an essential role in the pathogenesis of liver fibrosis. Methyl ferulic acid (MFA), a
Qi-Lai Cheng +8 more
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Liver fibrosis is a pathological wound-healing response caused by chronic liver damage due to a virus, autoimmune disorder, or drugs. Hepatic stellate cells (HSCs) play an essential role in the pathogenesis of liver fibrosis. Methyl ferulic acid (MFA), a
Qi-Lai Cheng +8 more
semanticscholar +1 more source
P311 modulates hepatic stellate cells migration
Liver International, 2014AbstractBackground & AimsLiver fibrosis is induced by the accumulation of extracellular matrix, deposited mainly by activated hepatic stellate cells (HSCs). One key characteristic of stellate cell activation is the directional migration to the site of injury during the wound‐healing process.
Stradiot, Leslie +4 more
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Hepatic fibrosis: It is time to go with hepatic stellate cell-specific therapeutic targets.
Hepatobiliary & Pancreatic Diseases International, 2018Hepatic fibrosis is a pathological lesion, characterized by the progressive accumulation of extracellular matrix (ECM) in the perisinusoidal space and it is a major problem in chronic liver diseases.
D. Ezhilarasan, E. Sokal, M. Najimi
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1998
The hepatic stellate cell (HSC) has emerged as a major regulator of normal liver homeostasis and growth, as well as a key effector in the hepatic fibrogenic response. In this chapter, we review the biological characteristics of the hepatic stellate cell, addressing historical perspectives, morphologic characteristics, methods of isolation, and their ...
Victor Ankoma-Sey, Scott L. Friedman
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The hepatic stellate cell (HSC) has emerged as a major regulator of normal liver homeostasis and growth, as well as a key effector in the hepatic fibrogenic response. In this chapter, we review the biological characteristics of the hepatic stellate cell, addressing historical perspectives, morphologic characteristics, methods of isolation, and their ...
Victor Ankoma-Sey, Scott L. Friedman
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018
Ferroptosis is recently reported as a new mode of regulated cell death. It is triggered by disturbed redox homeostasis, overloaded iron and increased lipid peroxidation. Howerver, the role of ferroptosis in hepatic fibrosis remains obscure.
Miao Sui +4 more
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Ferroptosis is recently reported as a new mode of regulated cell death. It is triggered by disturbed redox homeostasis, overloaded iron and increased lipid peroxidation. Howerver, the role of ferroptosis in hepatic fibrosis remains obscure.
Miao Sui +4 more
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Transcriptional Regulation in Hepatic Stellate Cells
Seminars in Liver Disease, 2001Modulation of gene expression through altered transcription regulates stellate cell behavior in normal liver and following hepatic injury. Transcription factors are generally classified according to conserved motifs within either the activation- or DNA- binding domains of the molecules.
F J, Eng, S L, Friedman
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Dilinoleoylphosphatidylcholine decreases hepatic stellate cell activation
Journal of Laboratory and Clinical Medicine, 1999The prevention of cirrhosis in alcohol-fed baboons by the administration of a soybean extract-43% to 50% of which was dilinoleoyl-phosphatidylcholine (DLPC) and 24% of which was 1,palmitoyl 2,linoleoyl-phosphatidylcholine (PLPC)-was associated with a significant reduction in the number of stellate cells transformed to myofibroblast-like cells. To study
J, Poniachik +3 more
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Science Translational Medicine, 2023
Advanced hepatic fibrosis, driven by the activation of hepatic stellate cells (HSCs), affects millions worldwide and is the strongest predictor of mortality in nonalcoholic steatohepatitis (NASH); however, there are no approved antifibrotic therapies. To
Shuang Wang +18 more
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Advanced hepatic fibrosis, driven by the activation of hepatic stellate cells (HSCs), affects millions worldwide and is the strongest predictor of mortality in nonalcoholic steatohepatitis (NASH); however, there are no approved antifibrotic therapies. To
Shuang Wang +18 more
semanticscholar +1 more source