Results 31 to 40 of about 42,587 (194)

Polyarteritis Nodosa – Risk of Stopping Immunosuppressent and a Rare Fatal Complication [PDF]

Modern Medicine, 2020
Background: Polyarteritis nodosa (PAN) is a systemic necrotising vasculitis which can cause multifocal aneurysms of visceral arteries, which may rupture causing haemorrhage, thrombosis, organ ischemia and infarction While the treatment of vasculitis ...
Akhil PAUL, Richa GUPTA, Devasahayam Jesudas CHRISTOPHER   +2 more
doaj   +1 more source

Hepatic tuberculosis presenting with extreme hyperferritinemia masquerading as adult-onset Still’s disease: a case report

Journal of Medical Case Reports, 2012
Introduction Isolated hepatic tuberculosis is an uncommon manifestation of one of the most common infections worldwide, caused by Mycobacterium tuberculosis. Extremely high serum ferritin, which is regarded as a marker of adult onset Still’s disease, has
Manoj Edirisooriya, Srigrishna Rajini, Ragunathan Murugapillai K   +2 more
doaj   +1 more source

A Diagnostic Dilemma: Isolated Hepatic Tuberculosis as A Rare And Unusual Presentation of TB

Acta Medica Iranica, 2020
Tuberculosis (TB) is the major problem being faced worldwide, particularly in developing countries, and therefore, it is important to recognize the unusual presentations of the disease.
Aamer Ubaid, Awais Naeem, Farishta Waheed   +2 more
doaj   +1 more source

Anisotropic Masked Mycobacterium Potentiates Amplified Antitumor Trained Immunity via Spleen Targeting and Myelopoiesis Conversion

Advanced Materials, EarlyView.
An engineered Trojan Mycobacterium, developed via a “peeling‐off and masking‐up” strategy, functions as a powerful splenic myelopoiesis converter. This spleen‐targeted nanomedicine induces trained immunity to reprogram immunosuppressive myeloid reservoirs into antitumoral effectors.
Jin‐Ho Choi, Sang Nam Lee, Jang Hun Heo, Soyoung Park, Sei Hyun Park, Yong Taik Lim   +5 more
wiley   +1 more source

Tuberculosis Presenting as Hepatic and Splenic Microabscesses [PDF]

Cureus, 2020
Tuberculosis (TB) is a major public health problem in developing countries. It can affect any organ of the body, and can have a multitude of clinical presentations. We present the case of a 22-year-old male who presented with fever, abdominal pain, and weight loss, and was found to have enlarged liver and spleen, both studded with multiple ...
Gaba, Saurabh, Dua, Ashish, Gaba, Nayana, Gupta, Monica, Agrawal, Suraj   +4 more
openaire   +2 more sources

CXCL10/SLC11A1 Axis Exacerbates Septic Liver Injury by Regulating Neutrophil Extracellular Traps Formation to Drive Macrophage Pro‑Inflammatory Polarization

Advanced Science, EarlyView.
In sepsis‐induced liver injury, marked neutrophil infiltration correlates with disease severity. Neutrophil SLC11A1 drives intracellular Fe2+ and ROS via the Fenton reaction, promoting NETs formation. Hepatocyte‐derived CXCL10 recruits neutrophils and activates the JAK/STAT1/SLC11A1 axis, enhancing NETs‐mediated inflammation.
Haiping Lin, Shicong Zheng, Pei Song, Jie Chang, Zewei Chen, Cang Li, Min Yu, Lude Wang, Shian Yu   +8 more
wiley   +1 more source

[Hepatic tuberculosis].

Pneumonologia i alergologia polska, 1998
Tuberculosis of the liver can be the only manifestation of the disease or it may be a part of disseminated process. Three cases of liver tuberculosis were presented. In one of them the process was restricted to the liver and the diagnosis was made only at autopsy. In two other cases, tuberculosis of the liver was a part of disseminated process.
M, Załeska, J, Słodkowska, P, Remiszewski, P, Obłakowski, E, Rowińska-Zakrzewska   +4 more
openaire   +3 more sources

Primary hepaticobiliary tuberculosis mimicking gall bladder carcinoma with liver metastasis: a case report

The Pan African Medical Journal, 2019
Primary hepatic tuberculosis is a rare presentation and sporadically reported in the literature, mostly from our part of the world. Sometimes the presentation can be atypical and mimics hepatic tumor and poses diagnostic challenge.
Muhammad Manzoor Ul Haque, Rajesh Kumar Whadva, Nasir Hassan Luck, Muhammed Mubarak   +3 more
doaj   +1 more source

PEAR1 Promotes Glucose Metabolism Reprogramming in Sepsis‐Associated Acute Lung Injury via AARS1‐Mediated HIF‐1α Lactylation

Advanced Science, EarlyView.
This study revealed that a PEAR1/HIF‐1α/ glycolysis/lactate/H3K18la positive feedback loop in PMVECs that drives the development of S‐ALI. Mechanistically, PEAR1 mediates the binding of HIF‐1α to AARS1, leading to the lactylation of HIF‐1α, the primary lactylation site of which is K172.
Shuai Li, Zongqing Lu, Pu Fang, Qingqing Pang, Xianghui Wu, Bo Wang, Min Liang, Jingjing Pan, Haobo Kong, Haijian Cai, Juanjuan Li, Jiaying Kang, Dongsheng Wang, Dunling Xia, Mengmeng Xu, Qinghai You   +15 more
wiley   +1 more source

p53 positively regulates the proliferation of hepatic progenitor cells promoted by laminin-521

Signal Transduction and Targeted Therapy, 2022
Hepatic progenitor cells (HPCs) hold tremendous potential for liver regeneration, but their well-known limitation of proliferation hampers their broader use.
Mingyang Ma, Shuyao Hua, Xiangde Min, Liang Wang, Jun Li, Ping Wu, Huifang Liang, Bixiang Zhang, Xiaoping Chen, Shuai Xiang   +9 more
doaj   +1 more source