Results 71 to 80 of about 70,676 (228)

No relevant pharmacokinetic interaction between the KRAS G12C inhibitor sotorasib and the direct oral anticoagulant rivaroxaban in healthy subjects

International Journal of Cancer, EarlyView.
What's New? Venous thromboembolism (VTE) is common in cancer patients, with direct oral anticoagulants, including rivaroxaban, recommended as first‐line therapy. However, oral anticoagulant use is limited due to the growing use of targeted therapy and concerns about drug‐drug interactions.
Esther M. Hollander, Alessandra I. G. Buma, Jenneke Leentjens, Paddy K. C. Janssen, Michel M. van den Heuvel, David M. Burger, Berber Piet, Rob ter Heine   +7 more
wiley   +1 more source

Natural history of a visceral leishmaniasis outbreak in highland Ethiopia [PDF]

, 2009
In May 2005, visceral leishmaniasis (VL) was recognized for the first time in Libo Kemken, Ethiopia, a highland region where only few cases had been reported before. We analyzed records of VL patients treated from May 25, 2005 to December 13, 2007 by the
Alvar, J, Aparicio, P, Argaw, D, Bashaye, S, Bern, C, Bernal, O, Flevaud, L, Herrero, M, Lima, M A, Mulugeta, A, Orfanos, G, Palma, P P, Parreño, F, Pedraza, J, Rubens, D   +14 more
core   +1 more source

Hepcidin and Host Defense against Infectious Diseases. [PDF]

, 2015
Hepcidin is the master regulator of iron homeostasis in vertebrates. The synthesis of hepcidin is induced by systemic iron levels and by inflammatory stimuli.
Ganz, Tomas, Mehrad, Borna, Michels, Kathryn, Nemeth, Elizabeta   +3 more
core   +1 more source

Primary/local hepatic tuberculosis without dissemination [PDF]

BMJ Case Reports, 2015
We present a rare case of primary hepatic tuberculosis in a 50-year-old man who presented with pain at the right hypochondrium. The diagnosis was established by fine-needle aspiration cytology (FNAC) of the primary hepatic lesions in both lobes of the liver, which was further supported by histopathological examination and tissue PCR forMycobacterium ...
Manoj, Meena, Ramakant, Dixit, Lalit Prashant, Meena, Jai Kumar, Samaria   +3 more
openaire   +2 more sources

Interpretable machine learning enables early and accurate detection of drug‐induced liver injury: A multicenter study with real‐world clinical translation

Interdisciplinary Medicine, EarlyView.
This study develops an interpretable gradient‐boosting model that accurately identifies drug‐induced liver injury (DILI) using routine laboratory data. The model explains key clinical features through SHapley Additive exPlanations analysis and detects DILI earlier than expert evaluation, offering a transparent and practical tool for precision ...
Jingyi Ling, Shian Zhang, Jun Lin, Zhengju Xu, Runcheng Xu, Qian Lv, Kaixiang Zhang, Sheng Liu, Jie Guo, Cheng Hua, Yin Jia, Xiaoyu Xu, Kun Qian, Shanrong Liu   +13 more
wiley   +1 more source

Extrahepatic complications of liver transplantation. [PDF]

, 1985
The massive surgical assault associated with hepatic transplantation makes a high frequency of complications almost inevitable. In this review of 225 patient records, selected at random from cases of liver transplantation in Pittsburgh over a 2 1/2 year ...
Shaw, BW, Starzl, TE, Wood, RP
core   +1 more source

Characteristics of Adult Patients With Atopic Dermatitis Initiating Biologics and Janus Kinase Inhibitors in the CorEvitas Atopic Dermatitis Registry

JEADV Clinical Practice, EarlyView.
ABSTRACT Background Biologics and Janus kinase inhibitors (JAKi) are two advanced systemic treatment options for patients with atopic dermatitis (AD). The decision to initiate one of these therapies is complex and may be driven by many factors.
Eric L. Simpson, Linda Stein Gold, Seemal R. Desai, Alexandra K. Golant, Douglas DiRuggiero, Christian Fenske, Yolanda Muñoz Maldonado, Alvin H. Li, Zach Dawson, Kaylee Ho, Kayla Callahan, Gaia Gallo, Jonathan I. Silverberg   +12 more
wiley   +1 more source

Hepatic tuberculosis mimicking Klatskin tumor: A diagnostic dilemma

Indian Journal of Pathology and Microbiology, 2008
Tubercular involvement of liver is rare and usually occurs in association with pulmonary or miliary tuberculosis, as diffuse involvement without recognizable pulmonary tuberculosis or rarely in a localized form, which presents as a tuberculoma or ...
Arora Raman, Sharma Alok, Bhowate Prashant, Bansal Vijender, Guleria Sandeep, Dinda Amit   +5 more
doaj  

Discharge against medical advice in paediatric patients

Journal of Taibah University Medical Sciences, 2019
الملخص: أهداف البحث: الخروج ضد المشورة الطبية من المستشفى قد يكون له تأثير سلبي على صحة المريض. هدفت هذه الدراسة إلى التحقيق في الأسباب الرئيسة للخروج ضد المشورة الطبية من قبل آباء الأطفال المنومين في جناح الأطفال في مستشفى علي بن أبي طالب في زاهدان ...
Manijeh Khalili, MD, Alireza Teimouri, Ph.D., Iraj Shahramian, MD, Narjes Sargolzaei, Ph.D., Jafar S. YazTappeh, MA, Mitra Farzanehfar, MD   +5 more
doaj   +1 more source

Potential Biomarkers for Disease Stratification and Prognosis Prediction in Pediatric Asthma: LCN2, sST2 and FGF21

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Pediatric asthma is a common chronic airway inflammatory disease, where accurate assessment of disease severity and prognosis prediction is crucial for treatment decisions. Currently, there is a lack of precise and effective biomarkers.
Xu Yang, Hai Wang, Yong‐Zheng Zhang, Yan‐Yan Chen, Xin‐Xin Xing, Yi‐Cheng Ding   +5 more
wiley   +1 more source