Results 171 to 180 of about 3,463,039 (240)

A CECT‐Based 2PI System as a Novel Noninvasive Prognostic Tool for Hepatocellular Carcinoma: A Dual‐Validation Study

Cancer Science, EarlyView.
Using differential weighting, we developed a 2PI‐based risk stratification system for HCC recurrence. A comprehensive prognostic model incorporating clinical variables and the 2PI score further enhanced postoperative prediction in solitary HCC and showed initial generalizability across SR and RFA cohorts.
Yingzhu Cui, Dezhi Zhang, Fan Lin, Liang Guo, Lei Zhang, Kan He, Hongbin Wang, Shuang Zheng, Kun Zhang, Yu Fu, Huimao Zhang   +10 more
wiley   +1 more source

Hepatic venous pressure gradient in patients with (compensated and decompensated) advanced chronic liver disease - A comparison of metabolic dysfunction-associated steatotic liver disease with alcohol-associated liver disease: A retrospective view. [PDF]

PLoS One
Skladaný Ĺ, Žilinčanová D, Žilinčan M, Okapec S, Danček F, Adamcová-Selčanová S, Kukla M, Koller T.   +7 more
europepmc   +1 more source

Splenic Stiffness Measurement: A New Frontier in the Management of Pediatric Portal Hypertension

Portal Hypertension &Cirrhosis, EarlyView.
Samannay Das, Tamoghna Biswas
wiley   +1 more source

Systematic Comparison of High‐Fat Diet– and Streptozotocin‐Induced Prediabetic Obese C57BL/6J Mouse Models: A Sex‐Based Protocol Optimization Study

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Animal models of prediabetes (Pre‐DM) are essential for studying metabolic disease and testing therapies, yet high‐fat diet (HFD) and HFD‐plus‐streptozotocin (STZ) protocols vary in feeding duration, STZ dose, and diagnostic criteria and rarely account for sex.
Min Xu, Chao Ke, Yangkun Liu, Wenying Shi, Yang Cao, Zhengyu Li, Yi Xiao, Wei Zhang   +7 more
wiley   +1 more source

The independent prognostic value of perioperative hepatic venous pressure gradient measurements in patients with portal hypertension who underwent laparoscopic splenectomy plus esophagogastric devascularization. [PDF]

BMC Gastroenterol
Zhang M, Wang D, Chen X, Liang D, Yang T, Cao Y, Huang B, Lu J, Yin J.   +8 more
europepmc   +1 more source

Therapies for Cardiovascular‐Kidney‐Liver‐Metabolic Syndrome: Reappraisal of Fibrates

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Cardiovascular disease, chronic kidney disease (CKD), type 2 diabetes mellitus (T2DM), obesity and metabolic dysfunction‐associated steatohepatitis (MASH) frequently coexist and share overlapping pathophysiology, forming the proposed cardiovascular‐kidney‐liver‐metabolic (CKLM) syndrome.
Virginia Anagnostopoulou, Christoforos K. Travlos, Lucas Lage Marinho, Thomas A. Mavrakanas, João Pedro Ferreira, Abhinav Sharma   +5 more
wiley   +1 more source

A Biweekly GLP‐1R Agonist Designed With Drug‐Free Intervals for Enhanced Efficacy, Receptor Homeostasis and Gastrointestinal Tolerability

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aim To develop a next‐generation, longer‐acting, more‐clinical‐benefits agonist to achieve sustained efficacy with improved tolerability. Methods CT130 was designed from semaglutide. Binding affinity was validated via molecular dynamics and cellular assays.
Wei Ding, Qing Liu, Qiong Luo, Xiaojun Yao, Xingxing Fan   +4 more
wiley   +1 more source

Higher Cardiorespiratory Fitness Is Associated With a Lower Burden of Metabolic Syndrome Traits: A Cross‐Sectional Analysis of 39 197 UK Adults

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims To investigate associations of cardiorespiratory fitness (CRF) with metabolic syndrome (MetS) trait count, MetS prevalence and individual MetS traits in a large population‐based cohort. Materials and Methods This cross‐sectional study analysed data for 39 197 adults from a UK‐based independent healthcare charity (mean ± SD: age, 45.8 ± 9 ...
Scott A. Willis, Annalena Phillipp, Kevin Deighton, Christopher Goodwin, Daniel J. Cuthbertson, Shelley E. Keating, Christopher J. A. Pugh, Jonathan G. Stine, Gaël Ennequin, Alexis Couret, David J. Stensel, Guruprasad P. Aithal, Thomas Yates, James A. King   +13 more
wiley   +1 more source

Predictive role of hepatic venous pressure gradient in bleeding events among patients with cirrhosis undergoing orthotopic liver transplantation. [PDF]

JHEP Rep
Giabicani M, Joly P, Sigaut S, Timsit C, Devauchelle P, Dondero F, Durand F, Froissant PA, Lamamri M, Payancé A, Restoux A, Roux O, Thibault-Sogorb T, Valainathan SR, Lesurtel M, Rautou PE, Weiss E.   +16 more
europepmc   +1 more source

Refining Residual Ischemic Stroke Risk in Anticoagulated Atrial Fibrillation Using Index Outpatient LA Diameter: The CHA2DS2‐VALa Score

Journal of Cardiovascular Electrophysiology, EarlyView.
In anticoagulated atrial fibrillation, residual ischemic stroke risk persists despite guideline‐directed therapy. In this single‐center cohort, an enlarged index outpatient left atrial diameter independently predicted stroke and improved risk stratification when added to CHA2DS2‐VA (CHA2DS2‐VALa), supporting a simple, clinically implementable ...
Sefa Erdi Ömür, Emin Koyun, Gülşen Genç Tapar, Kayıhan Karaman, Metin Karayakali, Ataç Çelik, Uğur Kulu, Yasin Taşkin   +7 more
wiley   +1 more source