Results 61 to 70 of about 3,463,039 (240)

Rhoifolin Alleviates Ulcerative Colitis by Targeting NMNAT1 and Activating SIRT1‐FOXO1 Signaling to Enhance ILC3s Effector Function

Advanced Science, EarlyView.
Rhoifolin directly targets NMNAT1, thereby activating nicotinamide salvage pathway and promoting intracellular NAD+ biosynthesis. Elevated NAD+ levels enhance SIRT1 activity, leading to FOXO1 deacetylation and nuclear translocation. Nuclear FOXO1 subsequently binds to the IL‐22 promoter, upregulating IL‐22 transcription and potentiating ILC3 effector ...
Hongqiong Yang, Yishu Zhang, Sijia Feng, Xiaoqing Ma, Jiayi Feng, Junwei Wang, Jialin Gao, An Pan, Dapeng Wu, Kang Ding, Caijuan Zheng, Qi Lv, Lihong Hu   +12 more
wiley   +1 more source

Portal Hypertension—Noninvasive Multiparametric Ultrasound‐Based Criteria and Measurements

Portal Hypertension & Cirrhosis
Portal hypertension, the most common complication in liver cirrhosis, is characterized by a pathologic increase in portal venous pressure. Portal hypertension is defined as a pressure gradient greater than 5 mmHg between the portal vein and the inferior ...
Kathleen Möller, Riyad Abu El Hija, Xiaolong Qi, Christian Jenssen, Sven Mutze, Burkhard Möller, Benjamin Misselwitz, Christoph F. Dietrich   +7 more
doaj   +1 more source

Engineering Morphological Anisotropy to Control the In Vivo Transport Dynamics, Clearance, and Biodistribution of Silica Nanocarriers

Advanced Science, EarlyView.
Morphological anisotropy directs the in vivo transport under physiological flow and clearance of silica nanocarriers. Increasing anisotropy reduces cellular uptake, suppresses hepatic and splenic sequestration, and prolongs systemic circulation by steering particles toward the central flow core.
Xiaofei Li, Yingjie Yu, Tianchang He, Xiaoyan Fang, Wenhua Yang, Luying Zhou, Hao Fan, Guimei Lin, Daniel Crespy, Katharina Landfester, Junfeng Zhang, Shuai Jiang   +11 more
wiley   +1 more source

Change of portal hepatic venous pressure gradient through TIPS-insertion over time.

, 2019
Change of portal hepatic venous pressure gradient through TIPS-insertion over time.
Yannick Schreiber (494694), Michael Praktiknjo (4854148), Robert Schierwagen (605493), Christian Markus Lange (6281903), Joan Clària (2636557), Gerd Geisslinger (109814), Christian Jansen (605490), Marcus Maximilian Mücke (5979365), Frank Erhard Uschner (3098256), Sabrina Rüschenbaum (5946641), Jonel Trebicka (206006), Dominique Thomas (3084342), Katharina Maria Schwarzkopf (6281894), Alexander Queck (6281897), Carsten Meyer (4854151), Stefan Zeuzem (22856)   +15 more
core   +1 more source

Alternating Shear Force of Respiration Regulates Cell Interactions of Fibroblasts and Macrophages to Promote Soft Tissue Integration of Chest Wall Polyetheretherketone Implants

Advanced Science, EarlyView.
Given that PEEK chest wall implants induce shear force at the soft tissue‐implant interface due to respiratory motion in the early in vivo post‐implantation stage. We confirmed that this mechanical stimulus triggers the PIEZO1/ITGB1/YAP1 signalling axis in L929 and the STAT6/p‐STAT6 pathway in RAW264.7, which in turn mediates adhesion and migration of ...
Rou Huang, Yangfan Huo, Jin Liu, Sida Liu, Minghai Ma, Hao Guo, Yuanquan Zhang, Xing Li, Xiao Liang, Jiawei Xiu, Ying Sun, Lijun Huang, Xiaolong Yan, Weiwei Wu, Lei Wang   +14 more
wiley   +1 more source

Comparison of artificial neural network-predicted PPG and HVPG with measured PPG in decompensated cirrhosis patients

Scientific Reports
Portal hypertension (PHT) is pivotal in managing decompensated cirrhosis. In clinical practice, hepatic venous collaterals are frequently present, often leading to failure or reduced accuracy of hepatic venous pressure gradient (HVPG) measurements ...
Zhonghua Wang, Ziwen Liu, Mengxin Lv, Yulin Wang, Yuanzi Yu, Tao Li, Jinhua Hu   +6 more
doaj   +1 more source

Recapitulating In Vivo Pharmacokinetics and Size‐Dependent Nanomedicine Delivery in a Microfluidic Platform

Advanced Science, EarlyView.
A microfluidic tumor platform integrates pharmacokinetic flow control, vascular‐like barriers, and 3D tumor spheroids to emulate in vivo drug exposure. The system reproduces dynamic concentration–time profiles and enables size‐dependent nanoparticle transport and efficacy evaluation, providing a predictive framework for assessing nanomedicine ...
Su Jeong Kang, Moon Sup Yoon, Jae Min Lee, Min Jeong Jo, Chae Eun Jin, Dae Hwan Shin   +5 more
wiley   +1 more source

Hepatic venous pressure gradient measurement in patients with liver cirrhosis: A correlation with disease severity and variceal bleeding

, 2009
The aim of present study was to evaluate relationships between degree of portal hypertension, severity of the disease, and bleeding status in patients with liver cirrhosis. Patients and methods.
Dalia Mitraitė, Vitalija Petrenkienė, Andrius Pranculis, Laimas Jonaitis, Limas Kupčinskas, Vilma Šilkauskaitė   +5 more
core   +1 more source

Nucleoside‐Modified mRNA Encoding Alpha‐Galactosidase A Ameliorates Fabry Disease Phenotypes in Human IPSC‐Derived Cardiomyocytes

Advanced Science, EarlyView.
Human iPSC‐derived Fabry cardiomyocytes exhibited broad transcriptional dysregulation, apoptosis, mitochondrial dysfunction, impaired reactive oxygen species handling, altered contractility, and abnormal calcium transient decay, potentially mediated by phospholamban hyperphosphorylation.
Malte Juchem, Lea Oehlsen, Sedef Ersoy, Jia Li Ye, Natalie Weber, Elisa Mohr, Wilson Agyapong, Junqing Liu, Maximilian Fuchs, Ke Xiao, Christopher Jahn, Reto Eggenschwiler, Tobias Cantz, Julia Beimdiek, Falk F. R. Buettner, Theresia Kraft, Jan Hegermann, Ivonne J. Knorr, Lisa Ernst, Linda Feldbrügge, Resa Puffert, Kevin Schmidt, Christian Bär, Jeannine Hoepfner, Thomas Thum   +24 more
wiley   +1 more source

Recent Advances in the Pathogenesis and Clinical Evaluation of Portal Hypertension in Chronic Liver Disease

Gut and Liver
In chronic liver disease, hepatic stellate cell activation and degeneration of liver sinusoidal endothelial cells lead to structural changes, which are secondary to fibrosis and the presence of regenerative nodules in the sinusoids, and to functional ...
Kohei Kotani, Norifumi Kawada
doaj   +1 more source