Results 41 to 50 of about 114,251,227 (259)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Immunological and epidemiological effectiveness of pediatric vaccination against hepatitis A using a single dose of inactivated vaccine

Журнал микробиологии, эпидемиологии и иммунобиологии
Hepatitis A is an acute liver disease caused by the hepatitis A virus (HAV), which can be prevented by means of vaccination. The standard hepatitis A vaccination schedule consists of two doses of inactivated vaccine, but for economic reasons and the ...
Mariya A. Lopatukhina, Karen K. Kyuregyan, Mikhail I. Mikhailov   +2 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Effectiveness of hepatitis B hyperimmunglobulin and vaccine in preventing perinatal transmission in children born from a mother with chronic B hepatitis

Zdorovʹe Rebenka, 2021
Background. Viral hepatitis is still one of the important health problems all over the world today. Hepatitis B is a life-threatening liver infection that can cause chronic infections.
Feyza Gökben Kahveci, Hasret Ayyildiz Civan, Özgül Salihoğlu   +2 more
doaj   +1 more source

Research progress of hepatitis B virus and its vaccine [PDF]

BIO Web of Conferences
Hepatitis B is a serious worldwide public health problem with a very high incidence. It is caused by the hepatitis B virus (HBV), and vaccination is the primary preventive measure. However, vaccine non-response or weak immune responses remain a challenge.
Huang Zhenghuai
doaj   +1 more source

Household survey of hepatitis B vaccine coverage among Brazilian children

, 2009
We conducted a multi-stage household cluster survey to calculate hepatitis B vaccine coverage among children 18-30 months of age in 27 Brazilian cities.
FLANNERY, Brendan, Vaccine Coverage Survey 2007 Grp, LUNA, Expedito J. A., MORAES, Jose Cassio de, VERAS, Maria Amelia S. M.   +4 more
core   +1 more source

Epidemiological patterns of hepatitis B virus (HBV) in highly endemic areas [PDF]

, 1996
This paper uses meta-analysis of published data and a deterministic mathematical model of hepatitis B virus (HBV) transmission to describe the patterns of HBV infection in high endemicity areas.
Edmunds, W. John, O'Callaghan, C. J., Medley, Graham, Nokes, D. James, Whittle, H. C., Hall, A. J. (Andrew James)   +5 more
core   +1 more source

The Development of Rheumatoid Arthritis–Specific Ambulatory Care–Sensitive Conditions: Results of a Consensus Process

Arthritis Care &Research, EarlyView.
Objective Ambulatory care–sensitive conditions (ACSCs) serve as indicators of access, quality, and performance of the health system. This study aimed to determine rheumatoid arthritis (RA)‐specific ACSCs for use in the evaluation of care system access and quality.
Kara Irwin, Candace H. Feldman, Claire E. H. Barber, Gabriel Fabreau, Jake Jennings, Scott Patten, Cheryl Barnabe, Inflammatory Arthritis‐Specific ACSC Consensus Process Working Group   +7 more
wiley   +1 more source

Immunogenicity assessment of Hepatitis A-VP1 and Hepatitis B surface antigen (HBsAg) fusion protein: a novel bivalent vaccine candidate

Iranian Journal of Microbiology
Background and Objectives: Subunit vaccines have the privilege of utilizing immunogenic parts of the variable viruses. The current preventive vaccines against Hepatitis A are based on live-attenuated virus or wild-type growth in cell culture, which is a
Mina Hannan, Leila Jabalameli, Mohammad Reza Aghasadeghi, Naser Harzandi, Seyed Mehdi Sadat   +4 more
doaj   +1 more source

Hepatitis B vaccine birth dose in India: time to reconsider

Human Vaccines & Immunotherapeutics, 2020
Viral hepatitis is increasingly being recognized as a public health problem in India with 96% of all hepatitis mortality attributed to hepatitis B and C combined.
Pragyan Paramita Parija, Mohan Kumar M
doaj   +1 more source