Challenge pools of hepatitis C virus genotypes 1-6 prototype strains: replication fitness and pathogenicity in chimpanzees and human liver-chimeric mouse models [PDF]
Chimpanzees represent the only animal model for studies of the natural history of hepatitis C virus (HCV). To generate virus stocks of important HCV variants, we infected chimpanzees with HCV strains of genotypes 1-6 and determined the infectivity titer ...
Bukh, Jens +11 more
core +1 more source
Hepatitis A virus (HAV) is one of the most common infectious etiologies of acute hepatitis worldwide. The virus is known to be transmitted fecal-orally, resulting in symptoms ranging from asymptomatic infection to fulminant hepatitis. HAV can also be transmitted through oral-anal sex.
Lin, Kuan-Yin +8 more
openaire +2 more sources
Assessment of the cross-protective capability of recombinant capsid proteins derived from pig, rat, and avian hepatitis E viruses (HEV) against challenge with a genotype 3 HEV in pigs [PDF]
Hepatitis E virus (HEV), the causative agent of hepatitis E, is primarily transmitted via the fecal-oral route through contaminated water supplies, although many sporadic cases of hepatitis E are transmitted zoonotically via direct contact with infected ...
Córdoba, Laura +5 more
core +1 more source
A Virus Similar to Human Hepatitis B Virus in Manchurian Chipmunks
In searching for a new host of the hepadna virus, we found a virus with many of the unique properties of the human hepatitis B virus (HBV) in sera from Manchurian chipmunks inhabiting Korea. Of 192 tested animals, 8 chipmunks were found to have weak HBsAg reactivities and particles similar in size and shape to the particles assoicated with HBV ...
Yoo, Byung Chul +4 more
openaire +2 more sources
Summary: Background and aim: Prisons in Egypt do not currently screen for blood-borne viruses, and there are no statistics concerning the prevalence of hepatitis C virus, hepatitis B virus or human immunodeficiency virus among prisoners.
Hala I. Mohamed +6 more
doaj +1 more source
Aim: To evaluate changes in liver histology in patients with human immunodeficiency virus/hepatitis C virus coinfection non-responders to a suboptimal Interferon + Ribavirine regimen. Materials and methods: We investigated 49 patients with two sequential
Caterina Sagnelli +8 more
doaj +1 more source
PCR detection and analyzis of potentially zoonotic Hepatitis E virus in French rats [PDF]
BACKGROUND: Hepatitis E virus has been detected in a wide range of animals. While Genotypes 1-2 of this virus infect only humans, 3-4 can spread from animals to humans and cause sporadic cases of human disease.
Ann-Sophie Olofson +4 more
core +1 more source
17,β-estradiol inhibits hepatitis C virus mainly by interference with the release phase of its life cycle [PDF]
Rationale & Aim: Estrogen and estrogen-mediated signalling protect from hepatitis C virus through incompletely understood mechanisms. We aimed to ascertain which phase(s) of HCV life cycle is/are affected by estrogens.
Barbaglia, Matteo N. +10 more
core +2 more sources
Persistent Infection of Human Fibroblasts by Hepatitis a Virus
Infection of human embryo fibroblasts with hepatitis A virus (HAV), a picornavirus, leads to an inapparent, persistent infection; cultures can be passed serially with consistent recovery of the virus in the supernatant. All of the cells of a HAV carrier culture are infected and proliferate. Subcultivation under HAV-immune serum cannot achieve a cure or
A, Vallbracht +3 more
openaire +2 more sources
The course of hepatitis E virus infection in pigs after contact-infection and intravenous inoculation [PDF]
Background - Worldwide, hepatitis E virus (HEV) genotype 3 is observed in pigs and transmission to humans is implied. To be able to estimate public health risks from e.g.
Bouwknegt, M. +7 more
core +2 more sources

