Results 41 to 50 of about 475,354 (308)

Prevalence of Hepatitis A Virus Antibody in Portuguese Travelers: A New Paradigm

Acta Médica Portuguesa, 2017
Introduction: In Portugal, the prevalence of hepatitis A virus infection has decreased in the past decades, especially in young adults. The aim of this study was to detect the prevalence of antibody to hepatitis A virus in a population observed in our ...
Sónia Rocha, Sandra Tejo, Eugénia Ferreira, Luís Trindade, Eduardo Rabadão, Nuno Marques, José Saraiva da Cunha   +6 more
doaj   +1 more source

Preferential association of hepatitis C virus with CD19+ B cells is mediated by complement system [PDF]

, 2016
Extrahepatic disease manifestations are common in chronic hepatitis C virus (HCV) infection. The mechanism of HCV-related lymphoproliferative disorders is not fully understood.
Alter, Harvey J., Baré, Patricia, De Giorgi, Valeria, Grandinetti, Teresa, Matsuura, Kentaro, Salam, Kazi Abdus, Schechterly, Cathy, Wang, Richard   +7 more
core   +1 more source

Simultaneous reconstruction of evolutionary history and epidemiological dynamics from viral sequences with the birth-death SIR model

, 2014
The evolution of RNA viruses such as HIV, Hepatitis C and Influenza virus occurs so rapidly that the viruses' genomes contain information on past ecological dynamics.
Drummond, Alexei J., Kühnert, Denise, Stadler, Tanja, Vaughan, Timothy G.   +3 more
core   +1 more source

IL28B is associated with outcomes of chronic HBV infection [PDF]

, 2015
Purpose The role of IL28B gene variants and expression in hepatitis B virus (HBV) infections are not well understood. Here, we evaluated whether IL28B gene expression and rs12979860 variations are associated with HBV outcomes.
Chi, Xiumei, Gao, Yanhang, Jiang, Jing, Li, Wanyu, Minuk, Gerald, Niu, Junqi, Pan, Yu, Shi, Xiaodong, Xu, Damo, Yang, Chen, Zhang, Manna, Zhong, Jin   +11 more
core   +1 more source

A genetically humanized mouse model for hepatitis C virus infection [PDF]

Nature, 2011
Hepatitis C virus (HCV) remains a major medical problem. Antiviral treatment is only partially effective and a vaccine does not exist. Development of more effective therapies has been hampered by the lack of a suitable small animal model. Although xenotransplantation of immunodeficient mice with human hepatocytes has shown promise, these models are ...
Dorner, M, Horwitz, JA, Robbins, JB, Barry, WT, Feng, Q, Mu, K, Jones, CT, Schoggins, JW, Catanese, MT, Burton, DR, Law, M, Rice, CM, Ploss, A   +12 more
openaire   +5 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Development and management of systemic lupus erythematosus in an HIV-infected man with hepatitis C and B co-infection following interferon therapy: a case report

Journal of Medical Case Reports, 2009
Introduction The association of human immunodeficiency virus and immune dysfunction leading to development of autoimmune markers is well described, but human immunodeficiency virus infection is relatively protective for the development of systemic lupus ...
Abbott Iain J, Chang Christina C, Skinner Matthew J, Street Alison, Perry Greg, McLean Catriona, Wright Edwina J, Cameron Paul U   +7 more
doaj   +1 more source

Hepatitis C virus NS5A targets the nucleosome assembly protein NAP1L1 to control the innate cellular response [PDF]

, 2017
Hepatitis C virus (HCV) is a single-stranded positive-sense RNA hepatotropic virus. Despite cellular defenses, HCV is able to replicate in hepatocytes and to establish a chronic infection that could lead to severe complications and hepatocellular ...
Cesarec, Mia, Da Silva Filipe, Ana, Licastro, Danilo, Marcello, Alessandro, McLauchlan, John, Çevik, Recep Emrah   +5 more
core   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

In vitro basal T-cell proliferation among asymptomatic Human T cell Leukemia Virus type 1 patients co-infected with hepatitis C and/or Human Immunodeficiency Virus type 1

Brazilian Journal of Infectious Diseases, 2018
Background: Infection with Human T cell Leukemia Virus type 1 can be associated with myelopathy/tropical spastic paraparesis (HAM/TSP) and other inflammatory diseases.
Tatiane Assone, Tatiana M. Kanashiro, Maira P.M. Baldassin, Arthur Paiva, Michel E. Haziot, Jerusa Smid, Augusto Penalva de Oliveira, Luiz Augusto M. Fonseca, Philip J. Norris, Jorge Casseb   +9 more
doaj   +1 more source